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PDBsum entry 2ffd
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Blood clotting
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PDB id
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2ffd
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Contents |
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65 a.a.
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303 a.a.
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298 a.a.
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57 a.a.
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* Residue conservation analysis
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PDB id:
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| Name: |
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Blood clotting
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Title:
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Fibrinogen fragment d with "a" knob peptide mimic gprvve
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Structure:
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Fibrinogen alpha/alpha-e chain. Chain: a, d. Fragment: residues 145-210. Engineered: yes. Fibrinogen beta chain. Chain: b, e. Fragment: residues 179-491. Engineered: yes. Fibrinogen gamma chain.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: fga. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary cells. Gene: fgb. Gene: fgg.
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Biol. unit:
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Pentamer (from
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Resolution:
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2.89Å
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R-factor:
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0.214
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R-free:
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0.268
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Authors:
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L.Betts
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Key ref:
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L.Betts
et al.
(2006).
The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE.
J Thromb Haemost,
4,
1139-1141.
PubMed id:
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Date:
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19-Dec-05
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Release date:
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04-Jul-06
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PROCHECK
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Headers
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References
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P02671
(FIBA_HUMAN) -
Fibrinogen alpha chain from Homo sapiens
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Seq:
Struc:
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866 a.a.
65 a.a.
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P02675
(FIBB_HUMAN) -
Fibrinogen beta chain from Homo sapiens
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Seq:
Struc:
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491 a.a.
303 a.a.
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J Thromb Haemost
4:1139-1141
(2006)
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PubMed id:
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The structure of fibrinogen fragment D with the 'A' knob peptide GPRVVE.
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L.Betts,
B.K.Merenbloom,
S.T.Lord.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.E.Stabenfeldt,
J.J.Gossett,
and
T.H.Barker
(2010).
Building better fibrin knob mimics: an investigation of synthetic fibrin knob peptide structures in solution and their dynamic binding with fibrinogen/fibrin holes.
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Blood,
116,
1352-1359.
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S.R.Bowley,
N.Okumura,
and
S.T.Lord
(2009).
Impaired protofibril formation in fibrinogen gamma N308K is due to altered D:D and "A:a" interactions.
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Biochemistry,
48,
8656-8663.
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PDB code:
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A.S.Wolberg
(2007).
Thrombin generation and fibrin clot structure.
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Blood Rev,
21,
131-142.
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D.K.Galanakis,
M.Neerman-Arbez,
T.Scheiner,
A.Henschen,
D.Hubbs,
C.Nagaswami,
and
J.W.Weisel
(2007).
Homophenotypic Aalpha R16H fibrinogen (Kingsport): uniquely altered polymerization associated with slower fibrinopeptide A than fibrinopeptide B release.
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Blood Coagul Fibrinolysis,
18,
731-737.
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R.I.Litvinov,
O.V.Gorkun,
D.K.Galanakis,
S.Yakovlev,
L.Medved,
H.Shuman,
and
J.W.Weisel
(2007).
Polymerization of fibrin: Direct observation and quantification of individual B:b knob-hole interactions.
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Blood,
109,
130-138.
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S.T.Lord
(2007).
Fibrinogen and fibrin: scaffold proteins in hemostasis.
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Curr Opin Hematol,
14,
236-241.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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