PDBsum entry 2fa5

Transcription

PDB id

2fa5

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Contents

			Protein chains

					139 a.a. *

			Metals

					_CL ×2

			Waters ×313

* Residue conservation analysis

PDB id:

2fa5

Links

Name:

Transcription

Title:

The crystal structure of an unliganded multiple antibiotic-resistance repressor (marr) from xanthomonas campestris

Structure:

Transcriptional regulator marr/emrr family. Chain: a, b. Synonym: multiple antibiotic-resistance repressor, marr. Engineered: yes

Source:

Xanthomonas campestris. Organism_taxid: 339. Expressed in: escherichia coli. Expression_system_taxid: 562

Biol. unit:

Dimer (from PQS)

Resolution:

1.80Å

R-factor:

0.200

R-free:

0.234

Authors:

K.H.Chin,Z.L.Tu,J.N.Li,C.C.Chou,A.H.J.Wang,S.H.Chou

Key ref:

K.H.Chin et al. (2006). The crystal structure of XC1739: a putative multiple antibiotic-resistance repressor (MarR) from Xanthomonas campestris at 1.8 A resolution. Proteins, 65, 239-242. PubMed id: 16862595 DOI: 10.1002/prot.21017

Date:

06-Dec-05

Release date:

14-Nov-06

PROCHECK

	Headers

	References

Protein chains

Q8PDA5 (Q8PDA5_XANCP) - Transcriptional regulator marR/emrR family from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)

Seq: Struc:					162 a.a. 139 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

DOI no: 10.1002/prot.21017	Proteins 65:239-242 (2006)
PubMed id: 16862595

The crystal structure of XC1739: a putative multiple antibiotic-resistance repressor (MarR) from Xanthomonas campestris at 1.8 A resolution.
K.H.Chin, Z.L.Tu, J.N.Li, C.C.Chou, A.H.Wang, S.H.Chou.

ABSTRACT

No abstract given.

Selected figure(s)



	Figure 1. Figure 1. (a) Sequence alignment of XC1739 with E. coli. MarR. The secondary structure elements were illustrated as green tubes for -helices and red arrows for -strands; the wing region was drawn as gray lines. Numbering starts according to the XC1739 primary sequence. Residues that are identical between the two sequences are colored in red, highly conserved in blue. Residues that are conserved and important in stabilizing dimerization domains are marked with a plus sign, while those important in forming hydrophobic core for each individual DNA-binding domain are denoted with an asterisk sign. (b) Ribbon representation of the XC1739 structural dimer. The secondary structures are colored coded from N-terminal to C-terminal in blue and green, and green and red, respectively, for each momoner. The electron density of the wing region is invisible and was marked as gray dots. (c) Stereodiagram of the electrostatic surface map of the XC1739 dimer. Positive charged residues are coded in blue and negative residues in red. (d) Superimposition diagram of the XC1739 dimer (colored in blue) with the liganded E. coli MarR dimer (colored in red). The diagrams are prepared using PdbViewer[18] except panel c, which is drawn using PyMol (DeLano Scientific LLC).

Literature references that cite this PDB file's key reference

PubMed id

Reference

20421503

Y.M.Chang, W.Y.Jeng, T.P.Ko, Y.J.Yeh, C.K.Chen, and A.H.Wang (2010).
Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis.

Proc Natl Acad Sci U S A, 107, 8617-8622.

PDB codes:

3kp2 3kp3 3kp4 3kp5 3kp6 3kp7

19255465

C.E.Nichols, S.Sainsbury, J.Ren, T.S.Walter, A.Verma, D.K.Stammers, N.J.Saunders, and R.J.Owens (2009).
The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis.

Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 204-209.

PDB code:

3g3z

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.