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PDBsum entry 2f8a
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Oxidoreductase
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PDB id
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2f8a
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1
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Structure:
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Glutathione peroxidase 1. Chain: a, b. Fragment: residues 12-196. Synonym: gshpx-1, gpx-1, cellular glutathione peroxidase. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: gpx1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
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Biol. unit:
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Tetramer (from PDB file)
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Resolution:
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1.50Å
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R-factor:
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0.138
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R-free:
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0.156
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Authors:
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K.L.Kavanagh,C.Johansson,C.Smee,O.Gileadi,F.Von Delft,J.Weigelt, M.Sundstrom,A.Edwards,U.Oppermann,Structural Genomics Consortium (Sgc)
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Key ref:
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K.L.Kavanagh
et al.
Crystal structure of the selenocysteine to glycine mu of human glutathione peroxidase 1.
To be published,
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Date:
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02-Dec-05
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Release date:
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13-Dec-05
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PROCHECK
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Headers
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References
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P07203
(GPX1_HUMAN) -
Glutathione peroxidase 1 from Homo sapiens
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Seq:
Struc:
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203 a.a.
186 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class:
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E.C.1.11.1.9
- glutathione peroxidase.
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Reaction:
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2 glutathione + H2O2 = glutathione disulfide + 2 H2O
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2
×
glutathione
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+
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H2O2
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=
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glutathione disulfide
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+
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2
×
H2O
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Cofactor:
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Se(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
