PDBsum entry 2df1

Hydrolase

PDB id: 2df1

Contents

Protein chains

247 a.a.

Ligands

EPE ×2

Waters ×193

Superseded by:

2ef1

PDB id:

2df1

Name:

Hydrolase

Title:

Crystal structure of the extracellular domain of human cd38

Structure:

Adp-ribosyl cyclase 1. Chain: a, b. Fragment: extracellular domain. Synonym: cyclic adp-ribose hydrolase 1, cadpr hydrolase 1, lymphocyte differentiation antigen cd38, t10, acute lymphoblastic leukemia cells antigen cd38. Engineered: yes

Source:

Homo sapiens. Human. Gene: cd38. Expressed in: escherichia coli.

Resolution:

2.40Å R-factor: 0.219 R-free: 0.269

Authors:

M.Kukimoto-Niino,O.Nureki,K.Murayama,M.Shirouzu,T.Katada, M.Hara-Yokoyama,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

M.Kukimoto-Niino et al. Crystal structure of the extracellular domain of human cd38. To be published, .

Date:

22-Feb-06 Release date: 30-Jan-07

Protein chains

P28907  (CD38_HUMAN) -  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 from Homo sapiens

Seq: 300 a.a.

Struc: 247 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.2.2.5 - NAD(+) glycohydrolase.
• Reaction: NAD⁺ + H2O = ADP-D-ribose + nicotinamide + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site