PDBsum entry 2cu2

Transferase

PDB id: 2cu2

Contents

Protein chain

335 a.a. *

Ligands

SO4 ×2

Waters ×233

* Residue conservation analysis

PDB id:

2cu2

Name:

Transferase

Title:

Crystal structure of mannose-1-phosphate geranyltransferase from thermus thermophilus hb8

Structure:

Putative mannose-1-phosphate guanylyl transferase. Chain: a. Synonym: mannose-1-phosphate geranyltransferase. Engineered: yes

Source:

Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Tetramer (from PDB file)

Resolution:

2.20Å R-factor: 0.219 R-free: 0.253

Authors:

M.Sugahara,N.Kunishima,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

M.Sugahara and n.kunishima Crystal structure of mannose-1-Phosphate guanyltransferase from thermus thermophilus hb8. To be published, .

Date:

25-May-05 Release date: 08-Aug-06

Protein chain

Q5SHI0  (Q5SHI0_THET8) -  Mannose-1-phosphate guanylyl transferase (GDP)/mannose-6-phosphate isomerase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)

Seq: 337 a.a.

Struc: 335 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.7.13 - mannose-1-phosphate guanylyltransferase.
• Pathway: GDP-L-Fucose and GDP-mannose Biosynthesis
• Reaction: alpha-D-mannose 1-phosphate + GTP + H⁺ = GDP-alpha-D-mannose + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site