PDBsum entry 2bl3

Hydrolase

PDB id: 2bl3

Contents

Protein chain

329 a.a.

Ligands

OPQ

Theoretical model

PDB id:

2bl3

Name:

Hydrolase

Title:

Theoretical interaction model of plasmepsin ii from plasmodium falciparum with a ligand from an ecoded statin combinatorial library

Structure:

Plasmepsin ii. Synonym: aspartic hemoglobinase ii, pfapd. Chain: a. Other_details: the submitted file is a complex of plasmepsin ii from plasmodium falciparum with a ligand from an encoded combinatorial library of statin

Source:

Synthetic: yes. Plasmodium falciparum. Malaria parasite. Organ: food vacuole

Authors:

S.Mahanta,S.Hazarika

Key ref:

S.Mahanta and s.hazarika Interaction model of plasmepsin ii with a molecule from statin combinatorial library. To be published, .

Date:

22-Feb-05 Release date: 03-Mar-05

Protein chain

P46925  (PLM2_PLAFA) -  Plasmepsin-2

Seq: 453 a.a.

Struc: 329 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.4.23.39 - plasmepsin Ii.
• Reaction: Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.