PDBsum entry 2ar5

Transferase

PDB id

2ar5

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Contents

			Protein chain

					117 a.a. *

			Ligands

					GOL ×6

			Waters ×92

* Residue conservation analysis

PDB id:

2ar5

Links

Name:

Transferase

Title:

Crystal structure of the mammalian c2alpha-pi3 kinase px-domain

Structure:

Phosphoinositide 3-kinase. Chain: a. Fragment: px-domain, residues 1421-1532. Synonym: phosphatidylinositol-4-phosphate 3-kinase c2 domain- containing alpha polypeptide, phosphoinositide 3-kinase-c2-alpha, ptdins-3-kinase c2 alpha, pi3k-c2alpha. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pi3kc2a. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.80Å

R-factor:

0.223

R-free:

0.244

Authors:

G.N.Parkinson,D.Vines,P.C.Driscoll,S.Djordjevic

Key ref:

G.N.Parkinson et al. Ligand-Binding specificity of pi3kinase c2alpha px domain.. To be published, .

Date:

19-Aug-05

Release date:

24-Oct-06

PROCHECK

	Headers

	References

Protein chain

O00443 (P3C2A_HUMAN) - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha from Homo sapiens

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					1686 a.a. 117 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 5 residue positions (black crosses)



		Enzyme reactions

Enzyme class 2:

E.C.2.7.1.137 - phosphatidylinositol 3-kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

1-Phosphatidyl-myo-inositol Metabolism

Reaction:

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H⁺

1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)	+	ATP	=	1,2-diacyl- sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)	+	ADP	+	H(+)

Enzyme class 3:

E.C.2.7.1.153 - phosphatidylinositol-4,5-bisphosphate 3-kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Reaction:

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + ADP + H⁺

1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)	+	ATP	=	1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate)	+	ADP	+	H(+)

Enzyme class 4:

E.C.2.7.1.154 - phosphatidylinositol-4-phosphate 3-kinase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Reaction:

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H⁺

1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)	+	ATP	=	1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate)	+	ADP	+	H(+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site