PDBsum entry 2a95

Membrane protein

PDB id: 2a95

Contents

Protein chain

301 a.a.

Theoretical model

PDB id:

2a95

Name:

Membrane protein

Title:

Homology modeling of human rhodopsin.

Structure:

Human rhodopsin. Chain: b

Source:

Homo sapiens. Human. Strain: cbrc7tm_231. Other_details: rhodopsin (opsin2, rod pigment)

Authors:

N.A.Jadhav

Key ref:

J.I.Levin et al. (2006). Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg Med Chem Lett, 16, 1605-1609. PubMed id: 16426848 DOI: 10.1016/j.bmcl.2005.12.020

Date:

11-Jul-05 Release date: 04-Oct-05

Protein chain

No UniProt id for this chain

Struc: 301 a.a.

DOI no: 10.1016/j.bmcl.2005.12.020

Bioorg Med Chem Lett 16:1605-1609 (2006)

PubMed id: 16426848

Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates.

J.I.Levin, J.M.Chen, L.M.Laakso, M.Du, J.Schmid, W.Xu, T.Cummons, J.Xu, G.Jin, D.Barone, J.S.Skotnicki.

ABSTRACT

A series of thiomorpholine sulfonamide hydroxamate TACE inhibitors, all bearing propargylic ether P1' groups, was explored. In particular, compound 5h has excellent in vitro potency against isolated TACE enzyme and in cells, oral activity in a model of TNF-alpha production and a collagen-induced arthritis model, was selected as a clinical candidate for the treatment of RA.