PDBsum entry 2a0s

Lyase, biosynthetic protein

PDB id: 2a0s

Contents

Protein chains

163 a.a. *

Ligands

BIO ×2

Metals

_ZN ×2

Waters ×186

* Residue conservation analysis

PDB id:

2a0s

Name:

Lyase, biosynthetic protein

Title:

Crystal structure of 6-pyruvoyl tetrahydropterin synthase (ptps) from plasmodium vivax at 2.2 a resolution

Structure:

6-pyruvoyl tetrahydropterin synthase. Chain: a, b. Engineered: yes

Source:

Plasmodium vivax. Malaria parasite p. Vivax. Organism_taxid: 5855. Gene: mal6p1.148. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Hexamer (from PDB file)

Resolution:

2.20Å R-factor: 0.210 R-free: 0.246

Authors:

J.Bosch,W.G.J.Hol,Structural Genomics Of Pathogenic Protozoa Consortium (Sgpp)

Key ref:

J.Bosch et al. Crystal structure of 6-Pyruvoyl tetrahydropterin synthase (ptps) from plasmodium vivax at 2.2 a resolution. To be published, .

Date:

16-Jun-05 Release date: 26-Jul-05

Protein chains

A5K2B2  (A5K2B2_PLAVS) -  6-pyruvoyltetrahydropterin synthase from Plasmodium vivax (strain Salvador I)

Seq: 172 a.a.

Struc: 163 a.a.

Enzyme reactions

• Enzyme class: E.C.4.2.3.12 - 6-pyruvoyltetrahydropterin synthase.
• Pathway: Biopterin Biosynthesis
• Reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin + triphosphate + H⁺

7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8- tetrahydropterin (Bound ligand (Het Group name = BIO) corresponds exactly) + triphosphate + H(+)

• Cofactor: Mg(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site