PDBsum entry 2zt6

Ligase

PDB id: 2zt6

Contents

Protein chain

530 a.a. *

Ligands

APC

Waters ×114

* Residue conservation analysis

PDB id:

2zt6

Name:

Ligase

Title:

Crystal structure of human glycyl-tRNA synthetase (glyrs) in complex with ampcpp

Structure:

Glycyl-tRNA synthetase. Chain: a. Fragment: unp residues 55-739. Synonym: glycine-tRNA ligase, glyrs. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gars. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

3.08Å R-factor: 0.225 R-free: 0.244

Authors:

R.T.Guo,X.L.Yang,P.Schimmel

Key ref:

R.T.Guo et al. Crystal structures and biochemical analyses suggest unique mechanism and role for human glyrs in ap4a homeostasis. To be published, .

Date:

19-Sep-08 Release date: 25-Aug-09

Protein chain

P41250  (GARS_HUMAN) -  Glycine--tRNA ligase from Homo sapiens

Seq: 739 a.a.

Struc: 530 a.a.

Enzyme reactions

• Enzyme class 2: E.C.2.7.7.- - ?????
• Enzyme class 3: E.C.6.1.1.14 - glycine--tRNA ligase.
• Reaction: tRNA(Gly) + glycine + ATP = glycyl-tRNA(Gly) + AMP + diphosphate

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site