PDBsum entry 2zsl

Isomerase

PDB id: 2zsl

Contents

Protein chain

420 a.a. *

Ligands

PMP

Waters ×426

* Residue conservation analysis

PDB id:

2zsl

Name:

Isomerase

Title:

Crystal structure of glutamate-1-semialdehyde 2,1-aminomutase from aeropyrum pernix

Structure:

Glutamate-1-semialdehyde 2,1-aminomutase. Chain: a. Synonym: gsa, glutamate-1-semialdehyde aminotransferase, gsa-at. Engineered: yes

Source:

Aeropyrum pernix. Organism_taxid: 56636. Strain: k1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.165 R-free: 0.188

Authors:

H.Mizutani,N.Kunishima

Key ref:

H.Mizutani and n.kunishima Crystal structure of glutamate-1-Semialdehyde 2,1-Aminomutase from aeropyrum pernix. To be published, .

Date:

17-Sep-08 Release date: 21-Oct-08

Protein chain

Q9Y9I9  (GSA_AERPE) -  Glutamate-1-semialdehyde 2,1-aminomutase from Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)

Seq: 429 a.a.

Struc: 420 a.a.

Enzyme reactions

• Enzyme class: E.C.5.4.3.8 - glutamate-1-semialdehyde 2,1-aminomutase.
• Pathway: Porphyrin Biosynthesis (early stages)
• Reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate
• Cofactor: Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate (Bound ligand (Het Group name = PMP) matches with 88.24% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site