PDBsum entry 2zp0

Hydrolase/blood clotting

PDB id: 2zp0

Contents

Protein chains

142 a.a. *

254 a.a. *

191 a.a. *

Ligands

BGC

FUC

PI0

Metals

_CA ×9

Waters ×299

* Residue conservation analysis

PDB id:

2zp0

Name:

Hydrolase/blood clotting

Title:

Human factor viia-tissue factor complexed with benzylsulfonamide-d- ile-gln-p-aminobenzamidine

Structure:

Factor vii light chain. Chain: l. Synonym: serum prothrombin conversion accelerator, spca, proconvertin, eptacog alfa. Engineered: yes. Factor vii heavy chain. Chain: h. Synonym: serum prothrombin conversion accelerator, spca, proconvertin, eptacog alfa.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: f7. Expressed in: cricetulus griseus. Expression_system_cell: cho. Gene: f3. Expressed in: escherichia coli.

Resolution:

2.70Å R-factor: 0.218 R-free: 0.306

Authors:

S.Kadono,A.Sakamoto,Y.Kikuchi,M.Oh-Eda,N.Yabuta,T.Koga,K.Hattori, T.Shiraishi,M.Haramura,H.Kodama

Key ref:

S.Kadono et al. (2005). Peptide mimetic factor viia inhibitor: importance of hydrophilic pocket in s2 site to improve selectivity aganist thrombin. Lett drug des discovery, 2, 177.

Date:

20-Jun-08 Release date: 15-Jul-08

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 142 a.a.*

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 254 a.a.

Protein chain

P13726  (TF_HUMAN) -  Tissue factor from Homo sapiens

Seq: 295 a.a.

Struc: 191 a.a.

* PDB and UniProt seqs differ at 10 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains L, H: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.