PDBsum entry 2zmv

Transport protein

PDB id

2zmv

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Contents

			Protein chains

					202 a.a. *

* Residue conservation analysis

PDB id:

2zmv

Links

Name:

Transport protein

Title:

Crystal structure of synbindin

Structure:

Trafficking protein particle complex subunit 4. Chain: a, b. Synonym: synbindin, trs23 homolog, hematopoietic stem/progenitor cell protein 172. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: trappc4, sbdn, cgi-104, hspc172, ptd009. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.80Å

R-factor:

0.245

R-free:

0.290

Authors:

F.Fan

Key ref:

S.Fan et al. (2009). Crystal structure of human synbindin reveals two conformations of longin domain. Biochem Biophys Res Commun, 378, 338-343. PubMed id: 18466758

Date:

21-Apr-08

Release date:

01-Jul-08

PROCHECK

	Headers

	References

Protein chains

Q9Y296 (TPPC4_HUMAN) - Trafficking protein particle complex subunit 4 from Homo sapiens

Seq: Struc:					219 a.a. 202 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.?

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Biochem Biophys Res Commun 378:338-343 (2009)
PubMed id: 18466758

Crystal structure of human synbindin reveals two conformations of longin domain.
S.Fan, Z.Wei, H.Xu, W.Gong.

ABSTRACT

Transport protein particle (TRAPP) is a large multiprotein complex that involves in ER-to-Golgi and intra-Golgi traffic. Synbindin, the human ortholog of yeast Trs23, is one component of the TRAPP complexes. In the hippocampal neurons the synbindin/syndecan complex is involved in synaptic membrane trafficking and thereby regulates the formation of dendritic spines. Here we present the three-dimensional structure of human synbindin, which contains a longin domain (LD) and an atypical PDZ domain (APD). In the crystal, synbindin forms a hexamer, in which the LD forms two different conformations and the APD is quite disordered. These conformational changes of synbindin suggest a possible interaction mode of the LD.

Literature references that cite this PDB file's key reference

PubMed id

Reference

19889231

M.Vedovato, V.Rossi, J.B.Dacks, and F.Filippini (2009).
Comparative analysis of plant genomes allows the definition of the "Phytolongins": a novel non-SNARE longin domain protein family.

BMC Genomics, 10, 510.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.