PDBsum entry 2zkx

Oxidoreductase

PDB id: 2zkx

Contents

Protein chains

153 a.a. *

118 a.a. *

Metals

_ZN ×4

CU1 ×4

Waters ×28

* Residue conservation analysis

PDB id:

2zkx

Name:

Oxidoreductase

Title:

Crystal structure of human cu-zn superoxide dismutase mutant g85r in space group i212121

Structure:

Superoxide dismutase [cu-zn]. Chain: a, b, c, d. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: sod1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.72Å R-factor: 0.176 R-free: 0.246

Authors:

S.Yoshikawa,M.Kukimoto-Niino,K.Ito,L.Chen,Z.Q.Fu,J.Chrzas,B.C.Wang, M.Shirouzu,M.Urushitani,R.Takahashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

S.Yoshikawa et al. Crystal structure of human cu-Zn superoxide dismutase mutant g85r in space group i212121. To be published, .

Date:

31-Mar-08 Release date: 24-Mar-09

Supersedes:

2yqw

Protein chains

P00441  (SODC_HUMAN) -  Superoxide dismutase [Cu-Zn] from Homo sapiens

Seq: 154 a.a.

Struc: 153 a.a.*

Protein chain

P00441  (SODC_HUMAN) -  Superoxide dismutase [Cu-Zn] from Homo sapiens

Seq: 154 a.a.

Struc: 118 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.1.15.1.1 - superoxide dismutase.
• Reaction: 2 superoxide + 2 H⁺ = H2O2 + O2
• Cofactor: Fe cation or Mn(2+) or (Zn(2+) and Cu cation)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site