PDBsum entry 2xzt

Hydrolase/protein binding

PDB id: 2xzt

Contents

Protein chains

141 a.a.

94 a.a.

119 a.a.

Ligands

MRD ×3

Waters ×164

PDB id:

2xzt

Name:

Hydrolase/protein binding

Title:

Caspase-3 in complex with darpin-3.4_i78s

Structure:

Caspase-3. Chain: a, c. Fragment: p17 subunit, residues 29-175. Synonym: casp-3, apopain, cysteine protease cpp32, cpp-32 protein yam, srebp cleavage activity 1, sca-1. Engineered: yes. Caspase-3. Chain: b, d. Fragment: p12 subunit, residues 176-277.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic construct. Organism_taxid: 32630. Other_details: t5 promoter expression

Resolution:

2.70Å R-factor: 0.199 R-free: 0.231

Authors:

J.Barandun,T.Schroeder,P.Mittl,M.G.Grutter

Key ref:

T.Schroeder et al. Caspase-3 in complex with darpin-3.4_i78s. To be published, .

Date:

29-Nov-10 Release date: 14-Dec-11

Protein chains

P42574  (CASP3_HUMAN) -  Caspase-3 from Homo sapiens

Seq: 277 a.a.

Struc: 141 a.a.*

Protein chains

P42574  (CASP3_HUMAN) -  Caspase-3 from Homo sapiens

Seq: 277 a.a.

Struc: 94 a.a.

Protein chains

No UniProt id for this chain

Struc: 119 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.3.4.22.56 - caspase-3.