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PDBsum entry 2xsw
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase
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Title:
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Crystal structure of human inpp5e
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Structure:
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72 kda inositol polyphosphate 5-phosphatase. Chain: a, b. Fragment: phosphatase domain, residues 275-623. Synonym: phosphatidylinositol-4\,5-bisphosphate 5-phosphatase, phosphatidylinositol polyphosphate 5-phosphatase type iv. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: mammalian gene collection (mgc)
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Resolution:
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1.90Å
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R-factor:
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0.167
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R-free:
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0.195
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Authors:
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L.Tresaugues,P.Schutz,C.H.Arrowsmith,H.Berglund,C.Bountra,R.Collins, A.M.Edwards,S.Flodin,A.Flores,S.Graslund,M.Hammarstrom,I.Johansson, T.Karlberg,S.Kol,T.Kotenyova,E.Kouznetsova,M.Moche,T.Nyman, C.Persson,H.Schuler,P.Schutz,M.I.Siponen,A.G.Thorsell,S.Van Der Berg,E.Wahlberg,J.Weigelt,M.Welin,P.Nordlund
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Key ref:
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L.Tresaugues
et al.
Crystal structure of human inpp5e.
To be published,
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Date:
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30-Sep-10
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Release date:
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17-Nov-10
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PROCHECK
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Headers
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References
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Q9NRR6
(INP5E_HUMAN) -
Phosphatidylinositol polyphosphate 5-phosphatase type IV from Homo sapiens
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Seq:
Struc:
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644 a.a.
340 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class 2:
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E.C.3.1.3.36
- phosphoinositide 5-phosphatase.
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Pathway:
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1-Phosphatidyl-myo-inositol Metabolism
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Reaction:
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
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+
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H2O
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=
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)
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+
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phosphate
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Enzyme class 3:
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E.C.3.1.3.86
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
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Reaction:
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a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4- bisphosphate) + phosphate
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)
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+
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H2O
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=
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1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4- bisphosphate)
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+
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phosphate
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
