PDBsum entry 2xrc

Immune system

PDB id: 2xrc

Contents

Protein chains

461 a.a.

485 a.a.

454 a.a.

464 a.a.

Ligands

NAG ×22

Metals

_CA ×8

PDB id:

2xrc

Name:

Immune system

Title:

Human complement factor i

Structure:

Human complement factor i. Chain: a, b, c, d. Synonym: c3b/c4b inactivator, complement factor i heavy chain, complement factor i light chain, kaf. Ec: 3.4.21.45

Source:

Homo sapiens. Human. Organism_taxid: 9606. Tissue: serum

Resolution:

2.69Å R-factor: 0.202 R-free: 0.238

Authors:

P.Roversi,S.Johnson,S.M.Lea

Key ref:

P.Roversi et al. (2011). Structural basis for complement factor I control and its disease-associated sequence polymorphisms. Proc Natl Acad Sci U S A, 108, 12839-12844. PubMed id: 21768352

Date:

13-Sep-10 Release date: 13-Jul-11

Protein chain

P05156  (CFAI_HUMAN) -  Complement factor I from Homo sapiens

Seq: 583 a.a.

Struc: 461 a.a.

Protein chain

P05156  (CFAI_HUMAN) -  Complement factor I from Homo sapiens

Seq: 583 a.a.

Struc: 485 a.a.

Protein chain

P05156  (CFAI_HUMAN) -  Complement factor I from Homo sapiens

Seq: 583 a.a.

Struc: 454 a.a.

Protein chain

P05156  (CFAI_HUMAN) -  Complement factor I from Homo sapiens

Seq: 583 a.a.

Struc: 464 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.3.4.21.45 - complement factor I.
• Reaction: Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.

Proc Natl Acad Sci U S A 108:12839-12844 (2011)

PubMed id: 21768352

Structural basis for complement factor I control and its disease-associated sequence polymorphisms.

P.Roversi, S.Johnson, J.J.Caesar, F.McLean, K.J.Leath, S.A.Tsiftsoglou, B.P.Morgan, C.L.Harris, R.B.Sim, S.M.Lea.

ABSTRACT

No abstract given.