PDBsum entry 2www

Transport protein

PDB id: 2www

Contents

Protein chains

298 a.a. *

299 a.a. *

314 a.a. *

Ligands

2PE ×3

GDP ×4

Waters ×87

* Residue conservation analysis

PDB id:

2www

Name:

Transport protein

Title:

Crystal structure of methylmalonic acidemia type a protein

Structure:

Methylmalonic aciduria type a protein, mitochondrial. Chain: a, b, c, d. Fragment: gtpase, residues 72-418. Synonym: methylmalonic acidemia type a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2

Resolution:

2.64Å R-factor: 0.184 R-free: 0.222

Authors:

J.R.C.Muniz,C.Gileadi,D.S.Froese,W.W.Yue,A.C.W.Pike,F.Von Delft, G.Kochan,R.Sethi,A.Chaikuad,E.Pilka,S.Picaud,C.Phillips,K.Guo, E.Krysztofinska,J.Bray,N.Burgess-Brown,C.H.Arrowsmith,J.Weigelt, A.Edwards,C.Bountra,R.A.Gravel,K.L.Kavanagh,U.Oppermann

Key ref:

D.S.Froese et al. (2010). Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation. J Biol Chem, 285, 38204-38213. PubMed id: 20876572

Date:

30-Oct-09 Release date: 17-Nov-09

Protein chain

Q8IVH4  (MMAA_HUMAN) -  Methylmalonic aciduria type A protein, mitochondrial from Homo sapiens

Seq: 418 a.a.

Struc: 298 a.a.

Protein chains

Q8IVH4  (MMAA_HUMAN) -  Methylmalonic aciduria type A protein, mitochondrial from Homo sapiens

Seq: 418 a.a.

Struc: 299 a.a.

Protein chain

Q8IVH4  (MMAA_HUMAN) -  Methylmalonic aciduria type A protein, mitochondrial from Homo sapiens

Seq: 418 a.a.

Struc: 314 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.3.6.-.-

J Biol Chem 285:38204-38213 (2010)

PubMed id: 20876572

Structures of the human GTPase MMAA and vitamin B12-dependent methylmalonyl-CoA mutase and insight into their complex formation.

D.S.Froese, G.Kochan, J.R.Muniz, X.Wu, C.Gileadi, E.Ugochukwu, E.Krysztofinska, R.A.Gravel, U.Oppermann, W.W.Yue.

ABSTRACT

No abstract given.