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PDBsum entry 2vvt
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Contents |
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* Residue conservation analysis
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PDB id:
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Isomerase
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Title:
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Glutamate racemase (muri) from e. Faecalis in complex with a 9-benzyl purine inhibitor
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Structure:
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Glutamate racemase. Chain: a, b. Fragment: residues 1-270. Engineered: yes
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Source:
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Enterococcus faecalis. Organism_taxid: 1351. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.65Å
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R-factor:
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0.152
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R-free:
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0.184
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Authors:
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B.Geng,G.Breault,J.Comita-Prevoir,R.Petrichko,C.Eyermann,T.Lundqvist, P.Doig,E.Gorseth,B.Noonan
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Key ref:
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B.Geng
et al.
(2008).
Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.
Bioorg Med Chem Lett,
18,
4368-4372.
PubMed id:
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Date:
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11-Jun-08
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Release date:
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24-Jun-08
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PROCHECK
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Headers
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References
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Q836J0
(MURI_ENTFA) -
Glutamate racemase from Enterococcus faecalis (strain ATCC 700802 / V583)
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Seq:
Struc:
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273 a.a.
270 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.5.1.1.3
- glutamate racemase.
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Reaction:
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L-glutamate = D-glutamate
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L-glutamate
Bound ligand (Het Group name = )
corresponds exactly
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=
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D-glutamate
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Cofactor:
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Pyridoxal 5'-phosphate
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Pyridoxal 5'-phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Bioorg Med Chem Lett
18:4368-4372
(2008)
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PubMed id:
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Exploring 9-benzyl purines as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria.
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B.Geng,
G.Breault,
J.Comita-Prevoir,
R.Petrichko,
C.Eyermann,
T.Lundqvist,
P.Doig,
E.Gorseth,
B.Noonan.
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ABSTRACT
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An early SAR study of a screening hit series has generated a series of 9-benzyl
purines as inhibitors of bacterial glutamate racemase (MurI) with micromolar
enzyme potency and improved physical properties. X-ray co-crystal EI structures
were obtained.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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M.A.Spies,
J.G.Reese,
D.Dodd,
K.L.Pankow,
S.R.Blanke,
and
J.Baudry
(2009).
Determinants of catalytic power and ligand binding in glutamate racemase.
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J Am Chem Soc,
131,
5274-5284.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
