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PDBsum entry 2pab
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Transport (thyroxine,retinol) in serum PDB id
2pab

 

 

 

 

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Contents
Protein chain
114 a.a. *
* Residue conservation analysis
PDB id:
2pab
Name: Transport (thyroxine,retinol) in serum
Title: Structure of prealbumin, secondary, tertiary and quaternary interactions determined by fourier refinement at 1.8 angstroms
Structure: Transthyretin precursor. Chain: a, b. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli
Biol. unit: Tetramer (from PQS)
Resolution:
1.80Å     R-factor:   0.290    
Authors: S.J.Oatley,C.C.F.Blake
Key ref:
C.C.Blake et al. (1978). Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A. J Mol Biol, 121, 339-356. PubMed id: 671542 DOI: 10.1016/0022-2836(78)90368-6
Date:
16-Sep-77     Release date:   24-Oct-77    
Supersedes: 1pab
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P02766  (TTHY_HUMAN) -  Transthyretin from Homo sapiens
Seq:
Struc: 		147 a.a.
114 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
DOI no: 10.1016/0022-2836(78)90368-6 J Mol Biol 121:339-356 (1978)
PubMed id: 671542  
 
 
Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A.
C.C.Blake, M.J.Geisow, S.J.Oatley, B.Rérat, C.Rérat.
 
  ABSTRACT  
 
No abstract given.

 
  Selected figure(s)  
 
Figure 7.
FIG. 7. Stereo drawg of he nternal water structure. Thick and thin lines isinuih the 2 rnonorners n the dimer. a) Shows the hydrogen ond network involving he water molecules, and b) their local nvironment in he imer. 		Figure 11.
FIQ. 11. Stereo drawing of the association of he DAGHH''A'U' hot% from ach ime1 looking down the axis with own and acmss. It, s n quivalent view t,o ig. (a) and the right-hand diagram of Fig. 9. The imer-dimw inbfaces arc ocated at, he edges of his truct,nrr.
 
  The above figures are reprinted by permission from Elsevier: J Mol Biol (1978, 121, 339-356) copyright 1978.  
  Figures were selected by an automated process.  

Literature references that cite this PDB file's key reference

  PubMed id Reference
21422279 F.Noborn, P.O'Callaghan, E.Hermansson, X.Zhang, J.B.Ancsin, A.M.Damas, I.Dacklin, J.Presto, J.Johansson, M.J.Saraiva, E.Lundgren, R.Kisilevsky, P.Westermark, and J.P.Li (2011).
Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein.
  Proc Natl Acad Sci U S A, 108, 5584-5589.  
  21504025 R.H.Pires, M.J.Saraiva, A.M.Damas, and M.S.Kellermayer (2011).
Structure and assembly-disassembly properties of wild-type transthyretin amyloid protofibrils observed with atomic force microscopy.
  J Mol Recognit, 24, 467-476.  
22120744 V.A.Rao, S.M.Shepherd, G.English, S.J.Coulthurst, and W.N.Hunter (2011).
The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system.
  Acta Crystallogr D Biol Crystallogr, 67, 1065-1072.
PDB code: 4a1r
20167108 J.Pessoa, Z.Sárkány, F.Ferreira-da-Silva, S.Martins, M.R.Almeida, J.Li, and A.M.Damas (2010).
Functional characterization of Arabidopsis thaliana transthyretin-like protein.
  BMC Plant Biol, 10, 30.  
  20927353 M.T.Ahonen, I.Diaconu, S.Pesonen, A.Kanerva, M.Baumann, S.T.Parviainen, B.Spiller, V.Cerullo, and A.Hemminki (2010).
Calcium gluconate in phosphate buffered saline increases gene delivery with adenovirus type 5.
  PLoS One, 5, 0.  
20043671 S.Choi, N.Reixach, S.Connelly, S.M.Johnson, I.A.Wilson, and J.W.Kelly (2010).
A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
  J Am Chem Soc, 132, 1359-1370.
PDB codes: 3imr 3ims 3imt 3imu 3imv 3imw
20133122 S.Connelly, S.Choi, S.M.Johnson, J.W.Kelly, and I.A.Wilson (2010).
Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.
  Curr Opin Struct Biol, 20, 54-62.  
19250316 E.Lundberg, A.Olofsson, G.T.Westermark, and A.E.Sauer-Eriksson (2009).
Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein.
  FEBS J, 276, 1999-2011.  
19293372 J.M.Weiss, P.L.Andersson, M.H.Lamoree, P.E.Leonards, S.P.van Leeuwen, and T.Hamers (2009).
Competitive binding of poly- and perfluorinated compounds to the thyroid hormone transport protein transthyretin.
  Toxicol Sci, 109, 206-216.  
19602727 L.Cendron, A.Trovato, F.Seno, C.Folli, B.Alfieri, G.Zanotti, and R.Berni (2009).
Amyloidogenic potential of transthyretin variants: insights from structural and computational analyses.
  J Biol Chem, 284, 25832-25841.
PDB codes: 3djr 3djs 3djt 3djz 3dk0 3dk2
19549717 L.Liu, J.Hou, J.Du, R.S.Chumanov, Q.Xu, Y.Ge, J.A.Johnson, and R.M.Murphy (2009).
Differential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity.
  Protein Eng Des Sel, 22, 479-488.  
18830126 M.Eriksson, J.Büttner, T.Todorov, S.Yumlu, S.Schönland, U.Hegenbart, A.V.Kristen, T.Dengler, P.Lohse, B.Helmke, H.Schmidt, and C.Röcken (2009).
Prevalence of germline mutations in the TTR gene in a consecutive series of surgical pathology specimens with ATTR amyloid.
  Am J Surg Pathol, 33, 58-65.  
19725883 P.Prapunpoj, and L.Leelawatwattana (2009).
Evolutionary changes to transthyretin: structure-function relationships.
  FEBS J, 276, 5330-5341.  
19725880 S.C.Hennebry (2009).
Evolutionary changes to transthyretin: structure and function of a transthyretin-like ancestral protein.
  FEBS J, 276, 5367-5379.  
19389624 S.J.Hyung, C.V.Robinson, and B.T.Ruotolo (2009).
Gas-phase unfolding and disassembly reveals stability differences in ligand-bound multiprotein complexes.
  Chem Biol, 16, 382-390.  
19621084 S.K.Palaninathan, N.N.Mohamedmohaideen, E.Orlandini, G.Ortore, S.Nencetti, A.Lapucci, A.Rossello, J.S.Freundlich, and J.C.Sacchettini (2009).
Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.
  PLoS One, 4, e6290.
PDB codes: 3glz 3gs0 3gs4 3gs7
19191553 S.M.Johnson, S.Connelly, I.A.Wilson, and J.W.Kelly (2009).
Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
  J Med Chem, 52, 1115-1125.
PDB codes: 3esn 3eso 3esp
19641588 T.Kawate, J.C.Michel, W.T.Birdsong, and E.Gouaux (2009).
Crystal structure of the ATP-gated P2X(4) ion channel in the closed state.
  Nature, 460, 592-598.
PDB codes: 3h9v 3i5d
19125186 T.Mairal, J.Nieto, M.Pinto, M.R.Almeida, L.Gales, A.Ballesteros, J.Barluenga, J.J.Pérez, J.T.Vázquez, N.B.Centeno, M.J.Saraiva, A.M.Damas, A.Planas, G.Arsequell, and G.Valencia (2009).
Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
  PLoS ONE, 4, e4124.
PDB codes: 3fc8 3fcb
18819112 A.Henze, S.Rohn, B.Gericke, J.Raila, and F.J.Schweigert (2008).
Structural modifications of serum transthyretin in rats during protein-energy malnutrition.
  Rapid Commun Mass Spectrom, 22, 3270-3274.  
19021760 G.Zanotti, C.Folli, L.Cendron, B.Alfieri, S.K.Nishida, F.Gliubich, N.Pasquato, A.Negro, and R.Berni (2008).
Structural and mutational analyses of protein-protein interactions between transthyretin and retinol-binding protein.
  FEBS J, 275, 5841-5854.
PDB codes: 3bsz 3bt0 3cxf
18161737 H.Heise (2008).
Solid-state NMR spectroscopy of amyloid proteins.
  Chembiochem, 9, 179-189.  
  19065295 M.Lindhagen-Persson, M.Vestling, N.Reixach, and A.Olofsson (2008).
Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form.
  Amyloid, 15, 240-245.  
18214980 M.Mizuguchi, A.Hayashi, M.Takeuchi, M.Dobashi, Y.Mori, H.Shinoda, T.Aizawa, M.Demura, and K.Kawano (2008).
Unfolding and aggregation of transthyretin by the truncation of 50 N-terminal amino acids.
  Proteins, 72, 261-269.  
18006495 N.Reixach, T.R.Foss, E.Santelli, J.Pascual, J.W.Kelly, and J.N.Buxbaum (2008).
Human-Murine Transthyretin Heterotetramers Are Kinetically Stable and Non-amyloidogenic: A LESSON IN THE GENERATION OF TRANSGENIC MODELS OF DISEASES INVOLVING OLIGOMERIC PROTEINS.
  J Biol Chem, 283, 2098-2107.
PDB code: 2qpf
18811132 S.M.Johnson, S.Connelly, I.A.Wilson, and J.W.Kelly (2008).
Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
  J Med Chem, 51, 6348-6358.
PDB codes: 3cn0 3cn1 3cn2 3cn3 3cn4
17968970 T.Sundsten, C.G.Ostenson, and P.Bergsten (2008).
Serum protein patterns in newly diagnosed type 2 diabetes mellitus-influence of diabetic environment and family history of diabetes.
  Diabetes Metab Res Rev, 24, 148-154.  
  17671371 A.Karlsson, and A.E.Sauer-Eriksson (2007).
Heating of proteins as a means of improving crystallization: a successful case study on a highly amyloidogenic triple mutant of human transthyretin.
  Acta Crystallogr Sect F Struct Biol Cryst Commun, 63, 695-700.
PDB code: 2qel
17211889 F.Dulin, I.Callebaut, N.Colloc'h, and J.P.Mornon (2007).
Sequence-based modeling of Abeta42 soluble oligomers.
  Biopolymers, 85, 422-437.  
17503405 K.Altland, M.D.Benson, C.E.Costello, A.Ferlini, B.P.Hazenberg, E.Hund, A.V.Kristen, R.P.Linke, G.Merlini, F.Salvi, M.J.Saraiva, R.Singer, M.Skinner, and P.Winter (2007).
Genetic microheterogeneity of human transthyretin detected by IEF.
  Electrophoresis, 28, 2053-2064.  
17554795 M.D.Benson, and J.C.Kincaid (2007).
The molecular biology and clinical features of amyloid neuropathy.
  Muscle Nerve, 36, 411-423.  
  19164912 M.T.Pastor, A.Esteras-Chopo, and L.Serrano (2007).
Hacking the code of amyloid formation: the amyloid stretch hypothesis.
  Prion, 1, 9.  
17143887 M.Takeuchi, M.Mizuguchi, T.Kouno, Y.Shinohara, T.Aizawa, M.Demura, Y.Mori, H.Shinoda, and K.Kawano (2007).
Destabilization of transthyretin by pathogenic mutations in the DE loop.
  Proteins, 66, 716-725.  
17360344 R.L.Julius, O.K.Farha, J.Chiang, L.J.Perry, and M.F.Hawthorne (2007).
Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores.
  Proc Natl Acad Sci U S A, 104, 4808-4813.  
17076759 X.Hou, H.C.Parkington, H.A.Coleman, A.Mechler, L.L.Martin, M.I.Aguilar, and D.H.Small (2007).
Transthyretin oligomers induce calcium influx via voltage-gated calcium channels.
  J Neurochem, 100, 446-457.  
17381508 X.Hou, M.I.Aguilar, and D.H.Small (2007).
Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.
  FEBS J, 274, 1637-1650.  
16627944 E.Morais-de-Sá, R.M.Neto-Silva, P.J.Pereira, M.J.Saraiva, and A.M.Damas (2006).
The binding of 2,4-dinitrophenol to wild-type and amyloidogenic transthyretin.
  Acta Crystallogr D Biol Crystallogr, 62, 512-519.
PDB codes: 2b14 2b15 2b16
  17062384 J.J.Liepnieks, D.L.Wilson, and M.D.Benson (2006).
Biochemical characterization of vitreous and cardiac amyloid in Ile84Ser transthyretin amyloidosis.
  Amyloid, 13, 170-177.  
16879610 P.Prapunpoj, L.Leelawatwatana, G.Schreiber, and S.J.Richardson (2006).
Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3.
  FEBS J, 273, 4013-4023.  
16783790 S.C.Hennebry, H.M.Wright, V.A.Likic, and S.J.Richardson (2006).
Structural and functional evolution of transthyretin and transthyretin-like proteins.
  Proteins, 64, 1024-1045.  
17163994 T.Sundsten, M.Eberhardson, M.Göransson, and P.Bergsten (2006).
The use of proteomics in identifying differentially expressed serum proteins in humans with type 2 diabetes.
  Proteome Sci, 4, 22.  
16698785 Y.Cordeiro, J.Kraineva, M.C.Suarez, A.G.Tempesta, J.W.Kelly, J.L.Silva, R.Winter, and D.Foguel (2006).
Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin.
  Biophys J, 91, 957-967.  
15793844 E.C.Pica, Z.A.Pramono, K.K.Verma, L.P.San, and Y.W.Chee (2005).
A novel transthyretin mutation V32A in a Chinese man with late-onset amyloid polyneuropathy.
  Muscle Nerve, 32, 223-225.  
16175629 E.Koh, and T.Kim (2005).
Minimal surface as a model of beta-sheets.
  Proteins, 61, 559-569.  
16286652 E.Refai, N.Dekki, S.N.Yang, G.Imreh, O.Cabrera, L.Yu, G.Yang, S.Norgren, S.M.Rössner, L.Inverardi, C.Ricordi, G.Olivecrona, M.Andersson, H.Jörnvall, P.O.Berggren, and L.Juntti-Berggren (2005).
Transthyretin constitutes a functional component in pancreatic beta-cell stimulus-secretion coupling.
  Proc Natl Acad Sci U S A, 102, 17020-17025.  
15846516 H.A.Montecinos, H.Richter, T.Caprile, and E.M.Rodríguez (2005).
Synthesis of transthyretin by the ependymal cells of the subcommissural organ.
  Cell Tissue Res, 320, 487-499.  
15810051 J.Bergström, A.Gustavsson, U.Hellman, K.Sletten, C.L.Murphy, D.T.Weiss, A.Solomon, B.O.Olofsson, and P.Westermark (2005).
Amyloid deposits in transthyretin-derived amyloidosis: cleaved transthyretin is associated with distinct amyloid morphology.
  J Pathol, 206, 224-232.  
15821170 M.Yang, M.Lei, R.Bruschweiler, and S.Huo (2005).
Initial conformational changes of human transthyretin under partially denaturing conditions.
  Biophys J, 89, 433-443.  
16195386 N.S.Green, T.R.Foss, and J.W.Kelly (2005).
Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis.
  Proc Natl Acad Sci U S A, 102, 14545-14550.  
16204882 P.Neumann, V.Cody, and A.Wojtczak (2005).
Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution.
  Acta Crystallogr D Biol Crystallogr, 61, 1313-1319.
PDB code: 1z7j
15735344 R.M.Neto-Silva, S.Macedo-Ribeiro, P.J.Pereira, M.Coll, M.J.Saraiva, and A.M.Damas (2005).
X-ray crystallographic studies of two transthyretin variants: further insights into amyloidogenesis.
  Acta Crystallogr D Biol Crystallogr, 61, 333-339.
PDB codes: 1x7s 1x7t
16533927 S.C.Meredith (2005).
Protein denaturation and aggregation: Cellular responses to denatured and aggregated proteins.
  Ann N Y Acad Sci, 1066, 181-221.  
16399646 S.Mitsuhashi, M.Yazaki, T.Tokuda, Y.Sekijima, Y.Washimi, Y.Shimizu, Y.Ando, M.D.Benson, and S.Ikeda (2005).
Biochemical characteristics of variant transthyretins causing hereditary leptomeningeal amyloidosis.
  Amyloid, 12, 216-225.  
14715898 C.P.Jaroniec, C.E.MacPhee, V.S.Bajaj, M.T.McMahon, C.M.Dobson, and R.G.Griffin (2004).
High-resolution molecular structure of a peptide in an amyloid fibril determined by magic angle spinning NMR spectroscopy.
  Proc Natl Acad Sci U S A, 101, 711-716.
PDB code: 1rvs
15469931 E.Morais-de-Sá, P.J.Pereira, M.J.Saraiva, and A.M.Damas (2004).
The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors.
  J Biol Chem, 279, 53483-53490.
PDB codes: 1tt6 1tz8
15033978 M.A.Liz, C.J.Faro, M.J.Saraiva, and M.M.Sousa (2004).
Transthyretin, a new cryptic protease.
  J Biol Chem, 279, 21431-21438.  
15082720 T.Eneqvist, E.Lundberg, A.Karlsson, S.Huang, C.R.Santos, D.M.Power, and A.E.Sauer-Eriksson (2004).
High resolution crystal structures of piscine transthyretin reveal different binding modes for triiodothyronine and thyroxine.
  J Biol Chem, 279, 26411-26416.
PDB codes: 1sn0 1sn2 1sn5
12876326 A.Lim, T.Prokaeva, M.E.McComb, L.H.Connors, M.Skinner, and C.E.Costello (2003).
Identification of S-sulfonation and S-thiolation of a novel transthyretin Phe33Cys variant from a patient diagnosed with familial transthyretin amyloidosis.
  Protein Sci, 12, 1775-1785.  
12538647 L.Gales, I.Cardoso, B.Fayard, A.Quintanilha, M.J.Saraiva, and A.M.Damas (2003).
X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization.
  J Biol Chem, 278, 11654-11660.  
12761393 M.Yang, M.Lei, and S.Huo (2003).
Why is Leu55-->Pro55 transthyretin variant the most amyloidogenic: insights from molecular dynamics simulations of transthyretin monomers.
  Protein Sci, 12, 1222-1231.  
12719214 S.Skoulakis, and J.M.Goodfellow (2003).
The pH-dependent stability of wild-type and mutant transthyretin oligomers.
  Biophys J, 84, 2795-2804.  
12542701 T.Eneqvist, E.Lundberg, L.Nilsson, R.Abagyan, and A.E.Sauer-Eriksson (2003).
The transthyretin-related protein family.
  Eur J Biochem, 270, 518-532.  
14690414 Y.Shinohara, M.Mizuguchi, K.Matsubara, M.Takeuchi, A.Matsuura, T.Aoki, K.Igarashi, H.Nagadome, Y.Terada, and K.Kawano (2003).
Biophysical analyses of the transthyretin variants, Tyr114His and Tyr116Ser, associated with familial amyloidotic polyneuropathy.
  Biochemistry, 42, 15053-15060.  
12219081 A.A.Serag, C.Altenbach, M.Gingery, W.L.Hubbell, and T.O.Yeates (2002).
Arrangement of subunits and ordering of beta-strands in an amyloid sheet.
  Nat Struct Biol, 9, 734-739.  
12481032 C.P.Jaroniec, C.E.MacPhee, N.S.Astrof, C.M.Dobson, and R.G.Griffin (2002).
Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril.
  Proc Natl Acad Sci U S A, 99, 16748-16753.  
12553420 G.Schreiber (2002).
The evolution of transthyretin synthesis in the choroid plexus.
  Clin Chem Lab Med, 40, 1200-1210.  
12553423 H.L.Monaco (2002).
Three-dimensional structure of the transthyretin-retinol-binding protein complex.
  Clin Chem Lab Med, 40, 1229-1236.  
12553433 J.A.Palha (2002).
Transthyretin as a thyroid hormone carrier: function revisited.
  Clin Chem Lab Med, 40, 1292-1300.  
12553422 J.A.Wilce, N.L.Daly, and D.J.Craik (2002).
Synthesis and structural analysis of the N-terminal domain of the thyroid hormone-binding protein transthyretin.
  Clin Chem Lab Med, 40, 1221-1228.  
12210822 M.D.Kirkitadze, G.Bitan, and D.B.Teplow (2002).
Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.
  J Neurosci Res, 69, 567-577.  
12553421 S.Gaetani, D.Bellovino, M.Apreda, and C.Devirgiliis (2002).
Hepatic synthesis, maturation and complex formation between retinol-binding protein and transthyretin.
  Clin Chem Lab Med, 40, 1211-1220.  
12553419 S.J.Richardson (2002).
The evolution of transthyretin synthesis in vertebrate liver, in primitive eukaryotes and in bacteria.
  Clin Chem Lab Med, 40, 1191-1199.  
12553424 V.Cody (2002).
Mechanisms of molecular recognition: crystal structure analysis of human and rat transthyretin inhibitor complexes.
  Clin Chem Lab Med, 40, 1237-1243.  
11478875 A.A.Serag, C.Altenbach, M.Gingery, W.L.Hubbell, and T.O.Yeates (2001).
Identification of a subunit interface in transthyretin amyloid fibrils: evidence for self-assembly from oligomeric building blocks.
  Biochemistry, 40, 9089-9096.  
11468389 A.Wojtczak, V.Cody, J.R.Luft, and W.Pangborn (2001).
Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites.
  Acta Crystallogr D Biol Crystallogr, 57, 1061-1070.
PDB code: 1ie4
  11409037 C.M.Chung, L.H.Connors, M.D.Benson, and M.T.Walsh (2001).
Biophysical analysis of normal transthyretin: implications for fibril formation in senile systemic amyloidosis.
  Amyloid, 8, 75-83.  
11344299 H.E.Purkey, M.I.Dorrell, and J.W.Kelly (2001).
Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma.
  Proc Natl Acad Sci U S A, 98, 5566-5571.  
  11733349 M.M.Sousa, I.Cardoso, R.Fernandes, A.Guimarães, and M.J.Saraiva (2001).
Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates.
  Am J Pathol, 159, 1993-2000.  
  11676293 T.Eneqvist, and A.E.Sauer-Eriksson (2001).
Structural distribution of mutations associated with familial amyloidotic polyneuropathy in human transthyretin.
  Amyloid, 8, 149-168.  
  11791618 Y.Sekijima, T.Tokuda, F.Kametani, K.Tanaka, K.Maruyama, and S.Ikeda (2001).
Serum transthyretin monomer in patients with familial amyloid polyneuropathy.
  Amyloid, 8, 257-262.  
10841549 A.D.Ferrão-Gonzales, S.O.Souto, J.L.Silva, and D.Foguel (2000).
The preaggregated state of an amyloidogenic protein: hydrostatic pressure converts native transthyretin into the amyloidogenic state.
  Proc Natl Acad Sci U S A, 97, 6445-6450.  
10861931 C.Zhang, and S.H.Kim (2000).
A comprehensive analysis of the Greek key motifs in protein beta-barrels and beta-sandwiches.
  Proteins, 40, 409-419.  
11001227 E.De Lorenzi, C.Galbusera, V.Bellotti, P.Mangione, G.Massolini, E.Tabolotti, A.Andreola, and G.Caccialanza (2000).
Affinity capillary electrophoresis is a powerful tool to identify transthyretin binding drugs for potential therapeutic use in amyloidosis.
  Electrophoresis, 21, 3280-3289.  
11058748 H.L.Monaco (2000).
The transthyretin-retinol-binding protein complex.
  Biochim Biophys Acta, 1482, 65-72.  
11106758 T.Eneqvist, K.Andersson, A.Olofsson, E.Lundgren, and A.E.Sauer-Eriksson (2000).
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Plasma retinol-binding protein.
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7012894 O.B.Ptitsyn, and A.V.Finkelstein (1980).
Similarities of protein topologies: evolutionary divergence, functional convergence or principles of folding?
  Q Rev Biophys, 13, 339-386.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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