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PDBsum entry 2izt
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Transferase
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Title:
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Structure of casein kinase gamma 3 in complex with inhibitor
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Structure:
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Casein kinase i isoform gamma-3. Chain: a. Fragment: residues 35-362. Synonym: cki-gamma 3, casein kinase 1 gamma 3. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.00Å
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R-factor:
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0.225
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R-free:
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0.277
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Authors:
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G.Bunkoczi,E.Salah,P.Rellos,S.Das,O.Fedorov,P.Savitsky, J.E.Debreczeni,O.Gileadi,M.Sundstrom,A.Edwards,C.Arrowsmith, J.Weigelt,F.Von Delft,S.Knapp
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Key ref:
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G.Bunkoczi
et al.
Inhibitor binding by casein kinases.
To be published,
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Date:
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26-Jul-06
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Release date:
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01-Aug-06
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PROCHECK
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Headers
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References
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Q9Y6M4
(KC1G3_HUMAN) -
Casein kinase I isoform gamma-3 from Homo sapiens
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Seq:
Struc:
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447 a.a.
296 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
Bound ligand (Het Group name = )
matches with 45.45% similarity
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
Bound ligand (Het Group name = )
matches with 45.45% similarity
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
