PDBsum entry 2igb

Transferase

PDB id: 2igb

Contents

Protein chains

172 a.a. *

Ligands

U5P ×2

EDO ×6

Waters ×286

* Residue conservation analysis

PDB id:

2igb

Name:

Transferase

Title:

Crystal structure of pyrr, the regulator of the pyrimidine biosynthetic operon in bacillus caldolyticus, ump-bound form

Structure:

Pyrr bifunctional protein. Chain: a, b. Synonym: pyrimidine operon regulatory protein, uracil phosphoribosyltransferase, uprtase. Engineered: yes

Source:

Bacillus caldolyticus. Organism_taxid: 1394. Gene: pyrr. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.68Å R-factor: 0.185 R-free: 0.224

Authors:

P.Chander,R.L.Switzer,J.L.Smith

Key ref:

P.Chander et al. Pyrr, The regulator of the pyrimidine biosynthetic operon in bacillus caldolyticus. To be published, .

Date:

22-Sep-06 Release date: 25-Sep-07

Protein chains

P41007  (PYRR_BACCL) -  Bifunctional protein PyrR from Bacillus caldolyticus

Seq: 179 a.a.

Struc: 172 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.2.9 - uracil phosphoribosyltransferase.
• Reaction: UMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + uracil

UMP + diphosphate (Bound ligand (Het Group name = U5P) corresponds exactly) = 5-phospho-alpha-D-ribose 1-diphosphate + uracil

Molecule diagrams generated from .mol files obtained from the KEGG ftp site