PDBsum entry 2d8s

Metal binding protein

PDB id: 2d8s

Contents

Protein chain

80 a.a. *

Metals

_ZN ×2

* Residue conservation analysis

PDB id:

2d8s

Name:

Metal binding protein

Title:

Solution structure of the ring domain of the human cellular modulator of immune recognition protein

Structure:

Cellular modulator of immune recognition. Chain: a. Fragment: ring domain. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: march8. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

K.Miyamoto,T.Kigawa,T.Tomizawa,S.Koshiba,M.Inoue,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

K.Miyamoto et al. Solution structure of the ring domain of the human cellular modulator of immune recognition protein. To be published, .

Date:

08-Dec-05 Release date: 08-Jun-06

Protein chain

Q5T0T0  (MARH8_HUMAN) -  E3 ubiquitin-protein ligase MARCHF8 from Homo sapiens

Seq: 291 a.a.

Struc: 80 a.a.*

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine