PDBsum entry 2cu0

Oxidoreductase

PDB id: 2cu0

Contents

Protein chains

358 a.a. *

Ligands

XMP ×2

Waters ×374

* Residue conservation analysis

PDB id:

2cu0

Name:

Oxidoreductase

Title:

Crystal structure of inosine-5'-monophosphate dehydrogenase from pyrococcus horikoshii ot3

Structure:

Inosine-5'-monophosphate dehydrogenase. Chain: a, b. Synonym: imp dehydrogenase, impdh, impd. Engineered: yes

Source:

Pyrococcus horikoshii. Organism_taxid: 53953. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Tetramer (from PDB file)

Resolution:

2.10Å R-factor: 0.205 R-free: 0.228

Authors:

Y.Asada,N.Kunishima,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

Y.Asada and n.kunishima Crystal structure of inosine-5'-Monophosphate dehydrogenase from pyrococcus horikoshii ot3. To be published, .

Date:

24-May-05 Release date: 24-May-06

Protein chains

O58045  (IMDH_PYRHO) -  Inosine-5'-monophosphate dehydrogenase from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)

Seq: 486 a.a.

Struc: 358 a.a.

Enzyme reactions

• Enzyme class: E.C.1.1.1.205 - Imp dehydrogenase.
• Pathway: AMP and GMP Biosynthesis
• Reaction: IMP + NAD⁺ + H2O = XMP + NADH + H⁺

IMP + NAD(+) + H2O = XMP + NADH + H(+) (Bound ligand (Het Group name = XMP) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site