PDBsum entry 2ar7

Transferase

PDB id: 2ar7

Contents

Protein chain

221 a.a. *

Waters ×314

* Residue conservation analysis

PDB id:

2ar7

Name:

Transferase

Title:

Crystal structure of human adenylate kinase 4, ak4

Structure:

Adenylate kinase 4. Chain: a, b. Synonym: atp-amp transphosphorylase, adenylate kinase isoenzyme 4, ak4. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ak3, ak4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Dimer (from PQS)

Resolution:

2.15Å R-factor: 0.169 R-free: 0.230

Authors:

P.Filippakopoulos,A.P.Turnbull,O.Fedorov,J.Weigelt,G.Bunkoczi, E.Ugochukwu,J.Debreczeni,F.Niesen,F.Von Delft,A.Edwards, C.Arrowsmith,M.Sundstrom,Structural Genomics Consortium (Sgc)

Key ref:

P.Filippakopoulos et al. Crystal structure of human adenylate kinase 4, Ak4. To be published, .

Date:

19-Aug-05 Release date: 06-Dec-05

Protein chains

P27144  (KAD4_HUMAN) -  Adenylate kinase 4, mitochondrial from Homo sapiens

Seq: 223 a.a.

Struc: 221 a.a.

Enzyme reactions

• Enzyme class 2: E.C.2.7.4.10 - nucleoside-triphosphate--adenylate kinase.
• Reaction: a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP
• Enzyme class 3: E.C.2.7.4.6 - nucleoside-diphosphate kinase.
• Reaction:
  1. a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP
  2. a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site