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PDBsum entry 1zr3
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protein ligands Protein-protein interface(s) links
Gene regulation PDB id
1zr3

 

 

 

 

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Contents
Protein chains
186 a.a. *
Ligands
MES
Waters ×447
* Residue conservation analysis
PDB id:
1zr3
Name: Gene regulation
Title: Crystal structure of the macro-domain of human core histone variant macroh2a1.1 (form b)
Structure: Histone macroh2a1.1. Chain: a, b, c, d. Fragment: non-histone macro-domain (residues: 162-369). Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Biol. unit: Monomer (from PQS)
Resolution:
1.66Å     R-factor:   0.190     R-free:   0.232
Authors: G.Kustatscher,M.Hothorn,C.Pugieux,K.Scheffzek,A.G.Ladurner
Key ref: K.G.Hoff and C.Wolberger (2005). Getting a grip on O-acetyl-ADP-ribose. Nat Struct Biol, 12, 560-561. PubMed id: 15999106
Date:
19-May-05     Release date:   14-Feb-06    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
O75367  (H2AY_HUMAN) -  Core histone macro-H2A.1 from Homo sapiens
Seq:
Struc: 		369 a.a.
186 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
Nat Struct Biol 12:560-561 (2005)
PubMed id: 15999106  
 
 
Getting a grip on O-acetyl-ADP-ribose.
K.G.Hoff, C.Wolberger.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
19251690 L.Tong, S.Lee, and J.M.Denu (2009).
Hydrolase regulates NAD+ metabolites and modulates cellular redox.
  J Biol Chem, 284, 11256-11266.  
19049465 P.Hu, S.Wang, and Y.Zhang (2008).
Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations.
  J Am Chem Soc, 130, 16721-16728.  
16959969 P.O.Hassa, S.S.Haenni, M.Elser, and M.O.Hottiger (2006).
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?
  Microbiol Mol Biol Rev, 70, 789-829.  
16684606 T.Yang, M.Fu, R.Pestell, and A.A.Sauve (2006).
SIRT1 and endocrine signaling.
  Trends Endocrinol Metab, 17, 186-191.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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