PDBsum entry 1ykc

Transferase

PDB id: 1ykc

Contents

Protein chain

217 a.a. *

Ligands

GDS ×2

Waters ×396

* Residue conservation analysis

PDB id:

1ykc

Name:

Transferase

Title:

Human glutathione s-transferase m2-2 (E.C.2.5.1.18) complexed with glutathione-disulfide

Structure:

Glutathione s-transferase mu 2. Chain: a, b. Synonym: gstm2-2, gst class-mu 2. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gstm2, gst4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Biol. unit:

Dimer (from PQS)

Resolution:

2.10Å R-factor: 0.206 R-free: 0.254

Authors:

Y.V.Patskovsky,L.N.Patskovska,I.Listowsky,S.C.Almo

Key ref:

Y.V.Patskovsky et al. Selective inhibitors of prostaglandin synthase activity of human glutathione s-Transferase m2-2. To be published, .

Date:

17-Jan-05 Release date: 25-Jan-05

Protein chains

P28161  (GSTM2_HUMAN) -  Glutathione S-transferase Mu 2 from Homo sapiens

Seq: 218 a.a.

Struc: 217 a.a.

Enzyme reactions

• Enzyme class: E.C.2.5.1.18 - glutathione transferase.
• Reaction: RX + glutathione = an S-substituted glutathione + a halide anion + H⁺

RX (Bound ligand (Het Group name = GDS) matches with 50.00% similarity) + glutathione = S-substituted glutathione + halide anion + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site