PDBsum entry 1xg7

Structural genomics, unknown function

PDB id: 1xg7

Contents

Protein chains

245 a.a. *

Waters ×133

* Residue conservation analysis

PDB id:

1xg7

Name:

Structural genomics, unknown function

Title:

Conserved hypothetical protein pfu-877259-001 from pyrococcus furiosus

Structure:

Hypothetical protein. Chain: a, b. Engineered: yes

Source:

Pyrococcus furiosus. Organism_taxid: 186497. Strain: dsm 3638. Expressed in: escherichia coli. Expression_system_taxid: 562

Biol. unit:

Dimer (from PQS)

Resolution:

1.88Å R-factor: 0.210 R-free: 0.261

Authors:

J.Chang,M.Zhao,P.Horanyi,H.Xu,H.Yang,Z.-J.Liu,L.Chen,W.Zhou,J.Habel, W.Tempel,D.Lee,D.Lin,S.-H.Chang,J.C.Eneh,R.C.Hopkins,F.E.Jenney Jr., H.-S.Lee,T.Li,F.L.Poole Ii,C.Shah,F.J.Sugar,C.-Y.Chen,W.B.Arendall Iii,J.S.Richardson,D.C.Richardson,J.P.Rose,M.W.W.Adams,B.-C.Wang, Southeast Collaboratory For Structural Genomics (Secsg)

Key ref:

J.Chang et al. Conserved hypothetical protein pfu-877259-001 from pyrococcus furiosus. To be published, .

Date:

16-Sep-04 Release date: 23-Nov-04

Protein chains

Q8U2D5  (AGOG_PYRFU) -  N-glycosylase/DNA lyase from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Seq: 242 a.a.

Struc: 245 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class 2: E.C.3.2.2.- - ?????
• Enzyme class 3: E.C.4.2.99.18 - DNA-(apurinic or apyrimidinic site) lyase.
• Reaction: 2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)- 2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3- dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho- 2'-deoxyribonucleoside-DNA + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.