PDBsum entry 1x6c

Signaling protein

PDB id: 1x6c

Contents

Protein chain

118 a.a. *

* Residue conservation analysis

PDB id:

1x6c

Name:

Signaling protein

Title:

Solution structures of the sh2 domain of human protein-tyrosine phosphatase shp-1

Structure:

Tyrosine-protein phosphatase, non-receptor type 6. Chain: a. Fragment: sh2 domain. Synonym: protein-tyrosine phosphatase 1c, ptp-1c, hematopoietic cell protein-tyrosine phosphatase, sh-ptp1, protein-tyrosine phosphatase shp-1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn6. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

M.Sato,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

M.Sato et al. Solution structures of the sh2 domain of human protein-Tyrosine phosphatase shp-1. To be published, .

Date:

17-May-05 Release date: 17-Nov-05

Protein chain

P29350  (PTN6_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 6 from Homo sapiens

Seq: 595 a.a.

Struc: 118 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site