PDBsum entry 1x5c

Isomerase

PDB id: 1x5c

Contents

Protein chain

121 a.a. *

* Residue conservation analysis

PDB id:

1x5c

Name:

Isomerase

Title:

The solution structure of the second thioredoxin-like domain of human protein disulfide-isomerase

Structure:

Protein disulfide-isomerase. Chain: a. Fragment: thioredoxin like domain. Synonym: pdi, prolyl 4- hydroxylase beta subunit, cellular thyroid hormone binding protein, p55. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: p4hb. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

N.Tochio,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

N.Tochio et al. The solution structure of the second thioredoxin-Like domain of human protein disulfide-Isomerase. To be published, .

Date:

15-May-05 Release date: 15-Nov-05

Protein chain

P07237  (PDIA1_HUMAN) -  Protein disulfide-isomerase from Homo sapiens

Seq: 508 a.a.

Struc: 121 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.5.3.4.1 - protein disulfide-isomerase.
• Reaction: Rearrangement of both intrachain and interchain disulfide bonds in proteins to form the native structures.