PDBsum entry 1vty

DNA

PDB id: 1vty

Contents

DNA/RNA

Ligands

NH2 ×2

Metals

_MG

Waters ×83

PDB id:

1vty

Name:

DNA

Title:

Crystal structure of a z-DNA fragment containing thymine/2- aminoadenine base pairs

Structure:

DNA (5'-d( Cp (Nh2)ap Cp Gp Tp G)-3'). Chain: a, b. Engineered: yes

Source:

Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Resolution:

1.30Å R-factor: 0.217

Authors:

M.Coll,A.H.-J.Wang,G.A.Van Der Marel,J.H.Van Boom,A.Rich

Key ref:

M.Coll et al. (1986). Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs. J Biomol Struct Dyn, 4, 157-172. PubMed id: 3271437 DOI: 10.1080/07391102.1986.10506337

Date:

18-Aug-88 Release date: 13-Jul-11

DNA/RNA chains

C-1AP-C-G-T-G 6 bases

C-1AP-C-G-T-G 6 bases

DOI no: 10.1080/07391102.1986.10506337

J Biomol Struct Dyn 4:157-172 (1986)

PubMed id: 3271437

Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs.

M.Coll, A.H.Wang, G.A.van der Marel, J.H.van Boom, A.Rich.

ABSTRACT

The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 A resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.