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PDBsum entry 1vtn
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protein dna_rna metals links
Transcription/DNA PDB id
1vtn

 

 

 

 

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Contents
Protein chain
102 a.a.
DNA/RNA
Metals
_MG
Waters ×5
PDB id:
1vtn
Name: Transcription/DNA
Title: Co-crystal structure of the hnf-3/fork head DNA-recognition motif resembles histone h5
Structure: DNA (5'-d( Gp Ap Cp Tp Ap Ap Gp Tp Cp Ap Ap Cp C)-3'). Chain: a. Engineered: yes. DNA (5'-d( Gp Gp Tp Tp Gp Ap Cp Tp Tp Ap Gp Tp C)-3'). Chain: b. Engineered: yes. Hnf-3/fork head DNA-recognition motif. Chain: c. Engineered: yes
Source: Synthetic: yes. Homo sapiens. Human
Resolution:
2.50Å     R-factor:   0.211    
Authors: K.L.Clark,E.D.Halay,E.Lai,S.K.Burley
Key ref: K.L.Clark et al. (1993). Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature, 364, 412-420. PubMed id: 8332212
Date:
06-Jan-95     Release date:   13-Jul-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P55318  (FOXA3_HUMAN) -  Hepatocyte nuclear factor 3-gamma from Homo sapiens
Seq:
Struc: 		350 a.a.
102 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

DNA/RNA chains
  G-A-C-T-A-A-G-T-C-A-A-C-C 13 bases
  G-G-T-T-G-A-C-T-T-A-G-T-C 13 bases

 

 
Nature 364:412-420 (1993)
PubMed id: 8332212  
 
 
Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.
K.L.Clark, E.D.Halay, E.Lai, S.K.Burley.
 
  ABSTRACT  
 
The three-dimensional structure of an HNF-3/fork head DNA-recognition motif complexed with DNA has been determined by X-ray crystallography at 2.5 A resolution. This alpha/beta protein binds B-DNA as a monomer, through interactions with the DNA backbone and through both direct and water-mediated major and minor groove base contacts, inducing a 13 degrees bend. The transcription factor fold is very similar to the structure of histone H5. In its amino-terminal half, three alpha-helices adopt a compact structure that presents the third helix to the major groove. The remainder of the protein includes a twisted, antiparallel beta-structure and random coil that interacts with the minor groove.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22610119 C.E.Barbieri, S.C.Baca, M.S.Lawrence, F.Demichelis, M.Blattner, J.P.Theurillat, T.A.White, P.Stojanov, E.Van Allen, N.Stransky, E.Nickerson, S.S.Chae, G.Boysen, D.Auclair, R.C.Onofrio, K.Park, N.Kitabayashi, T.Y.MacDonald, K.Sheikh, T.Vuong, C.Guiducci, K.Cibulskis, A.Sivachenko, S.L.Carter, G.Saksena, D.Voet, W.M.Hussain, A.H.Ramos, W.Winckler, M.C.Redman, K.Ardlie, A.K.Tewari, J.M.Mosquera, N.Rupp, P.J.Wild, H.Moch, C.Morrissey, P.S.Nelson, P.W.Kantoff, S.B.Gabriel, T.R.Golub, M.Meyerson, E.S.Lander, G.Getz, M.A.Rubin, and L.A.Garraway (2012).
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.
  Nat Genet, 44, 685-689.  
22555282 K.M.Jozwik, and J.S.Carroll (2012).
Pioneer factors in hormone-dependent cancers.
  Nat Rev Cancer, 12, 381-385.  
21878914 S.L.Kong, G.Li, S.L.Loh, W.K.Sung, and E.T.Liu (2011).
Cellular reprogramming by the conjoint action of ERα, FOXA1, and GATA3 to a ligand-inducible growth state.
  Mol Syst Biol, 7, 526.  
19416966 J.Silhan, P.Vacha, P.Strnadova, J.Vecer, P.Herman, M.Sulc, J.Teisinger, V.Obsilova, and T.Obsil (2009).
14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4.
  J Biol Chem, 284, 19349-19360.  
19274050 S.Hannenhalli, and K.H.Kaestner (2009).
The evolution of Fox genes and their role in development and disease.
  Nat Rev Genet, 10, 233-240.  
17244620 E.Boura, J.Silhan, P.Herman, J.Vecer, M.Sulc, J.Teisinger, V.Obsilova, and T.Obsil (2007).
Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding.
  J Biol Chem, 282, 8265-8275.  
17098741 K.Arita, H.Hashimoto, K.Igari, M.Akaboshi, S.Kutsuna, M.Sato, and T.Shimizu (2007).
Structural and biochemical characterization of a cyanobacterium circadian clock-modifier protein.
  J Biol Chem, 282, 1128-1135.
PDB code: 2e1n
17923482 M.Hatta, and L.A.Cirillo (2007).
Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1.
  J Biol Chem, 282, 35583-35593.  
17943136 S.S.Myatt, and E.W.Lam (2007).
The emerging roles of forkhead box (Fox) proteins in cancer.
  Nat Rev Cancer, 7, 847-859.  
16462749 D.T.Brown, T.Izard, and T.Misteli (2006).
Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.
  Nat Struct Mol Biol, 13, 250-255.  
16624804 K.L.Tsai, C.Y.Huang, C.H.Chang, Y.J.Sun, W.J.Chuang, and C.D.Hsiao (2006).
Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins.
  J Biol Chem, 281, 17400-17409.
PDB code: 2c6y
16670089 M.Fosbrink, F.Niculescu, V.Rus, M.L.Shin, and H.Rus (2006).
C5b-9-induced endothelial cell proliferation and migration are dependent on Akt inactivation of forkhead transcription factor FOXO1.
  J Biol Chem, 281, 19009-19018.  
15692568 D.Rudra, Y.Zhao, and J.R.Warner (2005).
Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins.
  EMBO J, 24, 533-542.  
15668254 H.Wan, S.Dingle, Y.Xu, V.Besnard, K.H.Kaestner, S.L.Ang, S.Wert, M.T.Stahlman, and J.A.Whitsett (2005).
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis.
  J Biol Chem, 280, 13809-13816.  
15817462 I.M.Kim, S.Ramakrishna, G.A.Gusarova, H.M.Yoder, R.H.Costa, and V.V.Kalinichenko (2005).
The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature.
  J Biol Chem, 280, 22278-22286.  
16144835 I.M.Kim, Y.Zhou, S.Ramakrishna, D.E.Hughes, J.Solway, R.H.Costa, and V.V.Kalinichenko (2005).
Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus.
  J Biol Chem, 280, 37908-37916.  
16150736 J.W.Lee, R.Kusumoto, K.M.Doherty, G.X.Lin, W.Zeng, W.H.Cheng, C.von Kobbe, R.M.Brosh, J.S.Hu, and V.A.Bohr (2005).
Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain.
  J Biol Chem, 280, 39627-39636.  
16183636 N.LaRonde-LeBlanc, and A.Wlodawer (2005).
A family portrait of the RIO kinases.
  J Biol Chem, 280, 37297-37300.  
15665870 S.Yoshizawa, L.Rasubala, T.Ose, D.Kohda, D.Fourmy, and K.Maenaka (2005).
Structural basis for mRNA recognition by elongation factor SelB.
  Nat Struct Mol Biol, 12, 198-203.
PDB code: 1wsu
15004549 C.Alfano, D.Sanfelice, J.Babon, G.Kelly, A.Jacks, S.Curry, and M.R.Conte (2004).
Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.
  Nat Struct Mol Biol, 11, 323-329.
PDB codes: 1s79 1s7a
15304484 F.M.Rausa, D.E.Hughes, and R.H.Costa (2004).
Stability of the hepatocyte nuclear factor 6 transcription factor requires acetylation by the CREB-binding protein coactivator.
  J Biol Chem, 279, 43070-43076.  
15516968 P.J.Coffer, and B.M.Burgering (2004).
Forkhead-box transcription factors and their role in the immune system.
  Nat Rev Immunol, 4, 889-899.  
15385550 T.J.Viney, T.W.Schmidt, W.Gierasch, A.W.Sattar, R.E.Yaggie, A.Kuburas, J.P.Quinn, J.M.Coulson, and A.F.Russo (2004).
Regulation of the cell-specific calcitonin/calcitonin gene-related peptide enhancer by USF and the Foxa2 forkhead protein.
  J Biol Chem, 279, 49948-49955.  
13679366 A.Meinhart, J.Blobel, and P.Cramer (2003).
An extended winged helix domain in general transcription factor E/IIE alpha.
  J Biol Chem, 278, 48267-48274.
PDB code: 1q1h
12702877 A.Morillon, J.O'Sullivan, A.Azad, N.Proudfoot, and J.Mellor (2003).
Regulation of elongating RNA polymerase II by forkhead transcription factors in yeast.
  Science, 300, 492-495.  
12692134 B.Wang, D.Lin, C.Li, and P.Tucker (2003).
Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors.
  J Biol Chem, 278, 24259-24268.  
12881514 R.García-Castellanos, A.Marrero, G.Mallorquí-Fernández, J.Potempa, M.Coll, and F.X.Gomis-Ruth (2003).
Three-dimensional structure of MecI. Molecular basis for transcriptional regulation of staphylococcal methicillin resistance.
  J Biol Chem, 278, 39897-39905.
PDB code: 1okr
14690436 T.Obsil, R.Ghirlando, D.E.Anderson, A.B.Hickman, and F.Dyda (2003).
Two 14-3-3 binding motifs are required for stable association of Forkhead transcription factor FOXO4 with 14-3-3 proteins and inhibition of DNA binding.
  Biochemistry, 42, 15264-15272.  
12867420 V.V.Kalinichenko, G.A.Gusarova, Y.Tan, I.C.Wang, M.L.Major, X.Wang, H.M.Yoder, R.H.Costa, and R.H.Costal (2003).
Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury.
  J Biol Chem, 278, 37888-37894.  
11782474 F.B.Berry, R.A.Saleem, and M.A.Walter (2002).
FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain.
  J Biol Chem, 277, 10292-10297.  
11877432 R.G.Zhang, Y.Kim, T.Skarina, S.Beasley, R.Laskowski, C.Arrowsmith, A.Edwards, A.Joachimiak, and A.Savchenko (2002).
Crystal structure of Thermotoga maritima 0065, a member of the IclR transcriptional factor family.
  J Biol Chem, 277, 19183-19190.
PDB code: 1mkm
11876636 W.Sheng, M.Rance, and X.Liao (2002).
Structure comparison of two conserved HNF-3/fkh proteins HFH-1 and genesis indicates the existence of folding differences in their complexes with a DNA binding sequence.
  Biochemistry, 41, 3286-3293.
PDB code: 1kq8
12221098 X.Wang, K.Krupczak-Hollis, Y.Tan, M.B.Dennewitz, G.R.Adami, and R.H.Costa (2002).
Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression.
  J Biol Chem, 277, 44310-44316.  
12228231 X.Zhang, L.Gan, H.Pan, S.Guo, X.He, S.T.Olson, A.Mesecar, S.Adam, and T.G.Unterman (2002).
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
  J Biol Chem, 277, 45276-45284.  
11779849 Z.Yang, J.Whelan, R.Babb, and B.R.Bowen (2002).
An mRNA splice variant of the AFX gene with altered transcriptional activity.
  J Biol Chem, 277, 8068-8075.  
11352721 J.Weigelt, I.Climent, K.Dahlman-Wright, and M.Wikström (2001).
Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4).
  Biochemistry, 40, 5861-5869.  
11226165 M.Ouhammouch, and E.P.Geiduschek (2001).
A thermostable platform for transcriptional regulation: the DNA-binding properties of two Lrp homologs from the hyperthermophilic archaeon Methanococcus jannaschii.
  EMBO J, 20, 146-156.  
11524677 T.Schwartz, J.Behlke, K.Lowenhaupt, U.Heinemann, and A.Rich (2001).
Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.
  Nat Struct Biol, 8, 761-765.
PDB code: 1j75
10777590 C.Pérez-Sánchez, M.A.Gómez-Ferrería, C.A.de La Fuente, B.Granadino, G.Velasco, A.Esteban-Gamboa, and J.Rey-Campos (2000).
FHX, a novel fork head factor with a dual DNA binding specificity.
  J Biol Chem, 275, 12909-12916.  
10716934 M.Okuda, Y.Watanabe, H.Okamura, F.Hanaoka, Y.Ohkuma, and Y.Nishimura (2000).
Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface.
  EMBO J, 19, 1346-1356.
PDB codes: 1d8j 1d8k
10702299 M.Tomizawa, A.Kumar, V.Perrot, J.Nakae, D.Accili, M.M.Rechler, and A.Kumaro (2000).
Insulin inhibits the activation of transcription by a C-terminal fragment of the forkhead transcription factor FKHR. A mechanism for insulin inhibition of insulin-like growth factor-binding protein-1 transcription.
  J Biol Chem, 275, 7289-7295.  
9867825 A.Cederberg, M.Hulander, P.Carlsson, and S.Enerbäck (1999).
The kidney-expressed winged helix transcription factor FREAC-4 is regulated by Ets-1. A possible role in kidney development.
  J Biol Chem, 274, 165-169.  
10455192 A.J.Crowe, L.Sang, K.K.Li, K.C.Lee, B.T.Spear, and M.C.Barton (1999).
Hepatocyte nuclear factor 3 relieves chromatin-mediated repression of the alpha-fetoprotein gene.
  J Biol Chem, 274, 25113-25120.  
10358014 E.D.Tang, G.Nuñez, F.G.Barr, and K.L.Guan (1999).
Negative regulation of the forkhead transcription factor FKHR by Akt.
  J Biol Chem, 274, 16741-16746.  
10581235 F.V.Murphy, R.M.Sweet, and M.E.Churchill (1999).
The structure of a chromosomal high mobility group protein-DNA complex reveals sequence-neutral mechanisms important for non-sequence-specific DNA recognition.
  EMBO J, 18, 6610-6618.
PDB code: 1qrv
10581239 I.Ohki, N.Shimotake, N.Fujita, M.Nakao, and M.Shirakawa (1999).
Solution structure of the methyl-CpG-binding domain of the methylation-dependent transcriptional repressor MBD1.
  EMBO J, 18, 6653-6661.
PDB code: 1d9n
9889202 M.Schade, C.J.Turner, K.Lowenhaupt, A.Rich, and A.Herbert (1999).
Structure-function analysis of the Z-DNA-binding domain Zalpha of dsRNA adenosine deaminase type I reveals similarity to the (alpha + beta) family of helix-turn-helix proteins.
  EMBO J, 18, 470-479.  
10358076 S.Guo, G.Rena, S.Cichy, X.He, P.Cohen, and T.Unterman (1999).
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.
  J Biol Chem, 274, 17184-17192.  
10364558 T.Schwartz, M.A.Rould, K.Lowenhaupt, A.Herbert, and A.Rich (1999).
Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.
  Science, 284, 1841-1845.
PDB code: 1qbj
10487755 Y.Fujii, T.Shimizu, M.Kusumoto, Y.Kyogoku, T.Taniguchi, and T.Hakoshima (1999).
Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.
  EMBO J, 18, 5028-5041.
PDB code: 2irf
9558357 C.Jin, I.Marsden, X.Chen, and X.Liao (1998).
Sequence specific collective motions in a winged helix DNA binding domain detected by 15N relaxation NMR.
  Biochemistry, 37, 6179-6187.  
9545321 H.Braun, and G.Suske (1998).
Combinatorial action of HNF3 and Sp family transcription factors in the activation of the rabbit uteroglobin/CC10 promoter.
  J Biol Chem, 273, 9821-9828.  
9516420 H.G.Patterton, C.C.Landel, D.Landsman, C.L.Peterson, and R.T.Simpson (1998).
The biochemical and phenotypic characterization of Hho1p, the putative linker histone H1 of Saccharomyces cerevisiae.
  J Biol Chem, 273, 7268-7276.  
9822702 H.Talasz, N.Sapojnikova, W.Helliger, H.Lindner, and B.Puschendorf (1998).
In vitro binding of H1 histone subtypes to nucleosomal organized mouse mammary tumor virus long terminal repeat promotor.
  J Biol Chem, 273, 32236-32243.  
9427758 L.A.Cirillo, C.E.McPherson, P.Bossard, K.Stevens, S.Cherian, E.Y.Shim, K.L.Clark, S.K.Burley, and K.S.Zaret (1998).
Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome.
  EMBO J, 17, 244-254.  
9722567 M.Hellqvist, M.Mahlapuu, A.Blixt, S.Enerbäck, and P.Carlsson (1998).
The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB.
  J Biol Chem, 273, 23335-23343.  
9685261 S.A.Duncan, M.A.Navas, D.Dufort, J.Rossant, and M.Stoffel (1998).
Regulation of a transcription factor network required for differentiation and metabolism.
  Science, 281, 692-695.  
9632694 S.Santagata, V.Aidinis, and E.Spanopoulou (1998).
The effect of Me2+ cofactors at the initial stages of V(D)J recombination.
  J Biol Chem, 273, 16325-16331.  
9233804 F.Rouyer, M.Rachidi, C.Pikielny, and M.Rosbash (1997).
A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock.
  EMBO J, 16, 3944-3954.  
9341214 I.Marsden, Y.Chen, C.Jin, and X.Liao (1997).
Evidence that the DNA binding specificity of winged helix proteins is mediated by a structural change in the amino acid sequence adjacent to the principal DNA binding helix.
  Biochemistry, 36, 13248-13255.  
9384590 J.Wong, Q.Li, B.Z.Levi, Y.B.Shi, and A.P.Wolffe (1997).
Structural and functional features of a specific nucleosome containing a recognition element for the thyroid hormone receptor.
  EMBO J, 16, 7130-7145.  
9360933 K.Lin, J.B.Dorman, A.Rodan, and C.Kenyon (1997).
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.
  Science, 278, 1319-1322.  
9242644 K.M.Yao, M.Sha, Z.Lu, and G.G.Wong (1997).
Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain.
  J Biol Chem, 272, 19827-19836.  
9214635 M.Zannini, V.Avantaggiato, E.Biffali, M.I.Arnone, K.Sato, M.Pischetola, B.A.Taylor, S.J.Phillips, A.Simeone, and R.Di Lauro (1997).
TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation.
  EMBO J, 16, 3185-3197.  
9182532 N.K.Kaludov, L.Pabón-Peña, M.Seavy, G.Robinson, and M.M.Hurt (1997).
A mouse histone H1 variant, H1b, binds preferentially to a regulatory sequence within a mouse H3.2 replication-dependent histone gene.
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8798534 F.Pio, R.Kodandapani, C.Z.Ni, W.Shepard, M.Klemsz, S.R.McKercher, R.A.Maki, and K.R.Ely (1996).
New insights on DNA recognition by ets proteins from the crystal structure of the PU.1 ETS domain-DNA complex.
  J Biol Chem, 271, 23329-23337.  
8798505 J.Sutton, R.Costa, M.Klug, L.Field, D.Xu, D.A.Largaespada, C.F.Fletcher, N.A.Jenkins, N.G.Copeland, M.Klemsz, and R.Hromas (1996).
Genesis, a winged helix transcriptional repressor with expression restricted to embryonic stem cells.
  J Biol Chem, 271, 23126-23133.  
8943227 L.A.Nolten, P.H.Steenbergh, and J.S.Sussenbach (1996).
The hepatocyte nuclear factor 3beta stimulates the transcription of the human insulin-like growth factor I gene in a direct and indirect manner.
  J Biol Chem, 271, 31846-31854.  
8626802 M.Hellqvist, M.Mahlapuu, L.Samuelsson, S.Enerbäck, and P.Carlsson (1996).
Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2.
  J Biol Chem, 271, 4482-4490.  
8605176 P.Dumoulin, R.H.Ebright, R.Knegtel, R.Kaptein, M.Granger-Schnarr, and M.Schnarr (1996).
Structure of the LexA repressor-DNA complex probed by affinity cleavage and affinity photo-cross-linking.
  Biochemistry, 35, 4279-4286.  
8910501 Q.Dang, and J.Taylor (1996).
In vivo footprinting analysis of the hepatic control region of the human apolipoprotein E/C-I/C-IV/C-II gene locus.
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8702877 S.Ernstsson, S.Pierrou, M.Hulander, A.Cederberg, M.Hellqvist, P.Carlsson, and S.Enerbäck (1996).
Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53.
  J Biol Chem, 271, 21094-21099.  
7592627 C.A.Spek, J.S.Greengard, J.H.Griffin, R.M.Bertina, and P.H.Reitsma (1995).
Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites.
  J Biol Chem, 270, 24216-24221.  
7592633 F.Pio, C.Z.Ni, R.S.Mitchell, J.Knight, S.McKercher, M.Klemsz, A.Lombardo, R.A.Maki, and K.R.Ely (1995).
Co-crystallization of an ETS domain (PU.1) in complex with DNA. Engineering the length of both protein and oligonucleotide.
  J Biol Chem, 270, 24258-24263.  
8530406 K.H.Kaestner, A.P.Monaghan, H.Kern, S.L.Ang, S.Weitz, P.Lichter, and G.Schütz (1995).
The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.
  J Biol Chem, 270, 30029-30035.  
7721856 V.Mach, S.Takiya, K.Ohno, H.Handa, T.Imai, and Y.Suzuki (1995).
Silk gland factor-1 involved in the regulation of Bombyx sericin-1 gene contains fork head motif.
  J Biol Chem, 270, 9340-9346.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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