PDBsum entry 1vlc

Dehydrogenase

PDB id

1vlc

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Contents

			Protein chain

					362 a.a. *

			Metals

					_CL

			Waters ×106

* Residue conservation analysis

PDB id:

1vlc

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- PDBePISA
- CSA
- ProSAT

Name:

Dehydrogenase

Title:

Crystal structure of 3-isopropylmalate dehydrogenase (tm0556) from thermotoga maritima at 1.90 a resolution

Structure:

3-isopropylmalate dehydrogenase. Chain: a. Synonym: beta-ipm dehydrogenase, imdh, 3-ipm-dh. Engineered: yes

Source:

Thermotoga maritima. Organism_taxid: 2336. Gene: leub, tm0556. Expressed in: escherichia coli. Expression_system_taxid: 562.

Biol. unit:

Dimer (from PDB file)

Resolution:

1.90Å

R-factor:

0.189

R-free:

0.218

Authors:

Joint Center For Structural Genomics (Jcsg)

Key ref:

Joint center for structural genomics (jcsg) Crystal structure of 3-Isopropylmalate dehydrogenase (tm0556) from thermotoga maritima at 1.90 a resolution. To be published, .

Date:

20-Jul-04

Release date:

21-Sep-04

PROCHECK

	Headers

	References

Protein chain

Q9WZ26 (LEU3_THEMA) - 3-isopropylmalate dehydrogenase from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)

Seq: Struc:					354 a.a. 362 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.1.1.1.85 - 3-isopropylmalate dehydrogenase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Leucine Biosynthesis

Reaction:

(2R,3S)-3-isopropylmalate + NAD⁺ = 4-methyl-2-oxopentanoate + CO2 + NADH

(2R,3S)-3-isopropylmalate	+	NAD(+)	=	4-methyl-2-oxopentanoate	+	CO2	+	NADH

Molecule diagrams generated from .mol files obtained from the KEGG ftp site