PDBsum entry 1vbt

Isomerase/isomerase substrate

PDB id: 1vbt

Contents

Protein chains

164 a.a. *

Ligands

ALA-ALT-PRO-PHE-NIT ×2

Waters ×204

* Residue conservation analysis

PDB id:

1vbt

Name:

Isomerase/isomerase substrate

Title:

Structure of cyclophilin complexed with sulfur-substituted tetrapeptide aapf

Structure:

Cyclophilin a. Chain: a, b. Engineered: yes. Sulfur-substituted tetrapeptide. Chain: c, d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Cell_line: xa-90 f'. Gene: cyclophilin. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: xa-90 f'. Synthetic: yes.

Biol. unit:

Tetramer (from PQS)

Resolution:

2.30Å R-factor: 0.198 R-free: 0.246

Authors:

Y.Zhao,Y.Chen,M.Schutkowski,G.Fischer,H.Ke

Key ref:

Y.Zhao et al. Insight into conversion of substrate to inhibitor. To be published, .

Date:

16-Jun-98 Release date: 13-Jan-99

Protein chains

P62937  (PPIA_HUMAN) -  Peptidyl-prolyl cis-trans isomerase A from Homo sapiens

Seq: 165 a.a.

Struc: 164 a.a.

Enzyme reactions

• Enzyme class: E.C.5.2.1.8 - peptidylprolyl isomerase.
• Reaction: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site