PDBsum entry 1urm

Antioxidant enzyme

PDB id: 1urm

Contents

Protein chain

162 a.a. *

Ligands

BEZ

Metals

_CL ×3

Waters ×285

* Residue conservation analysis

PDB id:

1urm

Name:

Antioxidant enzyme

Title:

Human peroxiredoxin 5, c47s mutant

Structure:

Peroxiredoxin 5. Chain: a. Fragment: residues 54-214. Synonym: prx-v, peroxisomal antioxidant enzyme, plp, thioredoxin peroxidase pmp20, antioxidant enzyme b166, aoeb166, tpx type vi, alu co-repressor 1. Engineered: yes. Mutation: yes. Other_details: mutation cys 47 ser in coordinates

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organ: lung. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.147 R-free: 0.169

Authors:

J.P.Declercq,C.Evrard

Key ref:

C.Evrard et al. (2004). Crystal structure of the c47s mutant of human peroxiredoxin 5. J chem cryst, 34, 553.

Date:

31-Oct-03 Release date: 29-Sep-04

Protein chain

P30044  (PRDX5_HUMAN) -  Peroxiredoxin-5, mitochondrial from Homo sapiens

Seq: 214 a.a.

Struc: 162 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.1.11.1.24 - thioredoxin-dependent peroxiredoxin.
• Reaction: a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]- disulfide + H2O

Molecule diagrams generated from .mol files obtained from the KEGG ftp site