PDBsum entry 1tk2

Hydrolase/antibiotic

PDB id: 1tk2

Contents

Protein chain

269 a.a. *

Ligands

VAL-ORN-LEU-DPN-PRO-VAL-ORN-LEU-DPN-PRO

Metals

_CA ×2

Waters ×192

* Residue conservation analysis

PDB id:

1tk2

Name:

Hydrolase/antibiotic

Title:

Crystal structure of the complex formed between alkaline proteinase savinase and gramicidin s at 1.5a resolution

Structure:

Subtilisin savinase. Chain: a. Synonym: alkaline protease. Gramicidin s. Chain: b. Synonym: gramicidin soviet. Engineered: yes

Source:

Bacillus lentus. Organism_taxid: 1467. Synthetic: yes. Brevibacillus brevis. Organism_taxid: 1393

Biol. unit:

Dimer (from PQS)

Resolution:

1.54Å R-factor: 0.170 R-free: 0.189

Authors:

V.S.Bhatt,P.Kaur,S.Klupsch,C.Betzel,S.Brenner,T.P.Singh

Key ref:

V.S.Bhatt et al. Crystal structure of the complex formed between alkaline proteinase savinase and gramicidin s at 1.5a resolution.. To be published, .

Date:

08-Jun-04 Release date: 22-Jun-04

Protein chain

P27487  (DPP4_HUMAN) -  Dipeptidyl peptidase 4 from Homo sapiens

Seq: 766 a.a.

Struc: 269 a.a.*

* PDB and UniProt seqs differ at 222 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.62 - subtilisin.
• Reaction: Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.