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PDBsum entry 1s1s
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Contents |
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* Residue conservation analysis
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PDB id:
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Cell cycle
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Title:
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Crystal structure of zipa in complex with indoloquinolizin 10b
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Structure:
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Cell division protein zipa. Chain: a, b. Engineered: yes
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Source:
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Escherichia coli. Organism_taxid: 562. Gene: zipa, b2412. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.10Å
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R-factor:
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0.226
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R-free:
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0.280
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Authors:
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L.D.Jennings,K.W.Foreman,T.S.Rush Iii,D.H.Tsao,L.Mosyak,Y.Li, M.N.Sukhdeo,W.Ding,E.G.Dushin,C.H.Kenny,S.L.Moghazeh,P.J.Petersen, A.V.Ruzin,M.Tuckman,A.G.Sutherland
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Key ref:
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L.D.Jennings
et al.
(2004).
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.
Bioorg Med Chem Lett,
14,
1427-1431.
PubMed id:
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Date:
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07-Jan-04
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Release date:
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18-Jan-05
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PROCHECK
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Headers
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References
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P77173
(ZIPA_ECOLI) -
Cell division protein ZipA from Escherichia coli (strain K12)
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Seq:
Struc:
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328 a.a.
139 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Bioorg Med Chem Lett
14:1427-1431
(2004)
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PubMed id:
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Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.
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L.D.Jennings,
K.W.Foreman,
T.S.Rush,
D.H.Tsao,
L.Mosyak,
Y.Li,
M.N.Sukhdeo,
W.Ding,
E.G.Dushin,
C.H.Kenny,
S.L.Moghazeh,
P.J.Petersen,
A.V.Ruzin,
M.Tuckman,
A.G.Sutherland.
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ABSTRACT
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The binding of FtsZ to ZipA is a potential target for antibacterial therapy.
Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel
synthesis of small molecules was initiated which targeted a key region of ZipA
involved in FtsZ binding. The X-ray crystal structure of one of these molecules
complexed with ZipA was solved. The structure revealed an unexpected binding
mode, facilitated by desolvation of a loosely bound surface water.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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D.Awasthi,
K.Kumar,
and
I.Ojima
(2011).
Therapeutic potential of FtsZ inhibition: a patent perspective.
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Expert Opin Ther Pat,
21,
657-679.
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Y.Ohta
(2010).
Construction of indole- and isoquinoline-fused nitrogen-containing heterocycles through copper-catalyzed multi-component reaction.
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Yakugaku Zasshi,
130,
925-936.
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R.L.Lock,
and
E.J.Harry
(2008).
Cell-division inhibitors: new insights for future antibiotics.
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Nat Rev Drug Discov,
7,
324-338.
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D.C.Fry
(2006).
Protein-protein interactions as targets for small molecule drug discovery.
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Biopolymers,
84,
535-552.
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I.S.Moreira,
P.A.Fernandes,
and
M.J.Ramos
(2006).
Detailed microscopic study of the full zipA:FtsZ interface.
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Proteins,
63,
811-821.
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J.J.Barker
(2006).
Antibacterial drug discovery and structure-based design.
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Drug Discov Today,
11,
391-404.
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W.Vollmer
(2006).
The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?
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Appl Microbiol Biotechnol,
73,
37-47.
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R.L.Rich,
and
D.G.Myszka
(2005).
Survey of the year 2004 commercial optical biosensor literature.
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J Mol Recognit,
18,
431-478.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
