Your browser does not support inline frames or is currently configured not to display inline frames. Content can be viewed at actual source page: inc/head.html
PDBsum entry 1pqw
Go to PDB code:
Oxidoreductase
PDB id
1pqw
Loading ...
Contents
Protein chains
183 a.a.
*
Metals
_CA
Waters
×141
*
Residue conservation analysis
PDB id:
1pqw
Links
PDBe
RCSB
MMDB
JenaLib
Proteopedia
CATH
SCOP
PDBSWS
PDBePISA
ProSAT
Name:
Oxidoreductase
Title:
Putative enoyl reductase domain of polyketide synthase
Structure:
Polyketide synthase. Chain: a, b. Fragment: putative enoyl reductase domain. Engineered: yes
Source:
Mycobacterium tuberculosis. Organism_taxid: 83331. Strain: cdc1551. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Biol. unit:
Dimer (from
PQS
)
Resolution:
2.66Å
R-factor:
0.197
R-free:
0.228
Authors:
A.Gogos,H.Mu,L.Shapiro,S.K.Burley,New York Sgx Research Center For Structural Genomics (Nysgxrc)
Key ref:
A.Gogos et al. Putative enoyl reductase domain of polyketide synthase.
To be published
, .
Date:
19-Jun-03
Release date:
08-Jul-03
PROCHECK
Headers
References
Protein chains
?
P96202
(PPSC_MYCTU) - Phenolphthiocerol/phthiocerol polyketide synthase subunit C from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Seq:
Struc:
Seq:
Struc:
Seq:
Struc:
Seq:
Struc:
Seq:
Struc:
2188 a.a.
183 a.a.
Key:
PfamA domain
Secondary structure
CATH domain
Enzyme reactions
Enzyme class:
E.C.2.3.1.292
- (phenol)carboxyphthiodiolenone synthase.
[IntEnz]
[ExPASy]
[KEGG]
[BRENDA]
Reaction:
1.
icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)- methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H
+
= C32- carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP
+
+ 5 CoA + 2 H2O
2.
docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)- methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H
+
= C34- carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP
+
+ 5 CoA + 2 H2O
3.
19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H
+
= C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP
+
+ 5 CoA + 2 H2O
4.
17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA
icosanoyl-[(phenol)carboxyphthiodiolenone synthase]
+
2 × (S)- methylmalonyl-CoA
+
3 × malonyl-CoA
+
5 × NADPH
+
10 × H(+)
=
C32- carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase]
+
5 × CO2
+
5 × NADP(+)
+
5 × CoA
+
2 × H2O
docosanoyl-[(phenol)carboxyphthiodiolenone synthase]
+
2 × (S)- methylmalonyl-CoA
+
3 × malonyl-CoA
+
5 × NADPH
+
10 × H(+)
=
C34- carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase]
+
5 × CO2
+
5 × NADP(+)
+
5 × CoA
+
2 × H2O
19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase]
+
2 × (S)-methylmalonyl-CoA
+
3 × malonyl-CoA
+
5 × NADPH
+
10 × H(+)
=
C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase]
+
5 × CO2
+
5 × NADP(+)
+
5 × CoA
+
2 × H2O
17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase]
+
2 × (S)-methylmalonyl-CoA
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
Links
