PDBsum entry 1kl6

Hydrolase/hydrolase inhibitor

PDB id: 1kl6

Contents

Protein chain

316 a.a. *

Ligands

PHQ-ALA

Metals

_CA ×4

_ZN

Waters ×158

* Residue conservation analysis

PDB id:

1kl6

Name:

Hydrolase/hydrolase inhibitor

Title:

Thermolysin complexed with z-l-alanine (benzyloxycarbonyl-l-alanine)

Structure:

Thermolysin. Chain: a. Ec: 3.4.24.27

Source:

Bacillus thermoproteolyticus. Organism_taxid: 1427

Resolution:

1.80Å R-factor: 0.164 R-free: 0.180

Authors:

M.Senda,T.Senda,S.Kidokoro

Key ref:

M.Senda et al. Crystal structure analyses of thermolysin in complex with its inhibitors.. To be published, .

Date:

11-Dec-01 Release date: 11-Dec-02

Protein chain

P00800  (THER_BACTH) -  Thermolysin from Bacillus thermoproteolyticus

Seq: 548 a.a.

Struc: 316 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.24.27 - thermolysin.
• Reaction: Preferential cleavage: Xaa-|-Leu > Xaa-|-Phe.
• Cofactor: Ca(2+); Zn(2+)