|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
219 a.a.
|
|
|
|
|
|
|
|
|
|
|
212 a.a.
|
|
|
|
|
|
|
|
|
|
|
103 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Membrane protein
|
|
|
Title:
|
|
Potassium channel kcsa-fab complex in high concentration of k+
|
|
Structure:
|
|
Antibody fab fragment heavy chain. Chain: a. Antibody fab fragment light chain. Chain: b. Potassium channel kcsa. Chain: c. Fragment: potassium channel kcsa. Engineered: yes. Mutation: yes
|
|
Source:
|
|
Mus musculus. House mouse. Organism_taxid: 10090. Streptomyces lividans. Organism_taxid: 1916. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Biol. unit:
|
|
Dodecamer (from PDB file)
|
|
Resolution:
|
|
|
2.00Å
|
R-factor:
|
0.218
|
R-free:
|
0.233
|
|
|
Authors:
|
|
Y.Zhou,J.H.Morais-Cabral,A.Kaufman,R.Mackinnon
|
Key ref:
|
|
Y.Zhou
et al.
(2001).
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature,
414,
43-48.
PubMed id:
DOI:
|
|
|
Date:
|
|
|
07-Oct-01
|
Release date:
|
14-Nov-01
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
No UniProt id for this chain
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
DOI no:
|
Nature
414:43-48
(2001)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
|
|
Y.Zhou,
J.H.Morais-Cabral,
A.Kaufman,
R.MacKinnon.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
Ion transport proteins must remove an ion's hydration shell to coordinate the
ion selectively on the basis of its size and charge. To discover how the K+
channel solves this fundamental aspect of ion conduction, we solved the
structure of the KcsA K+ channel in complex with a monoclonal Fab antibody
fragment at 2.0 A resolution. Here we show how the K+ channel displaces water
molecules around an ion at its extracellular entryway, and how it holds a K+ ion
in a square antiprism of water molecules in a cavity near its intracellular
entryway. Carbonyl oxygen atoms within the selectivity filter form a very
similar square antiprism around each K+ binding site, as if to mimic the waters
of hydration. The selectivity filter changes its ion coordination structure in
low K+ solutions. This structural change is crucial to the operation of the
selectivity filter in the cellular context, where the K+ ion concentration near
the selectivity filter varies in response to channel gating.
|
|
|
|
|
|
| |
Selected figure(s)
|
|
|
|
| |
|
|
|
|
|
|
Figure 2.
Figure 2: Stereo view of electron density in the region of the
K+ channel selectivity filter. The 2F[o] - F[c] electron
density map (contoured at 2  )
covers amino acids forming the selectivity filter (two
diagonally opposed subunits are shown), with K+ ions (green
spheres) along the ion pathway, and water molecules (red
spheres) in the vicinity.
|
|
Figure 3.
Figure 3: Stereo view of a hydrated K+ ion in the central
cavity. Eight water molecules (red spheres) surround a single
K+ ion (green sphere) in the cavity. The 2F[o] - F[c] electron
density map is contoured at 2 .
Residues forming the cavity are shown in ball-and-stick
representation. For clarity, only backbone atoms and the side
chains facing the cavity (Thr 75, Ile 100, Phe 103, Gly 104 and
Thr 107) are shown. The subunit closest to the viewer has been
removed.
|
|
|
|
|
|
| |
The above figures are
reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2001,
414,
43-48)
copyright 2001.
|
|
| |
Figures were
selected
by an automated process.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
A.D.Lawson
(2012).
Antibody-enabled small-molecule drug discovery.
|
| |
Nat Rev Drug Discov,
11,
519-525.
|
|
|
|
|
|
|
P.Yuan,
M.D.Leonetti,
Y.Hsiung,
and
R.MacKinnon
(2012).
Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel.
|
| |
Nature,
481,
94-97.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
V.N.Bavro,
R.De Zorzi,
M.R.Schmidt,
J.R.Muniz,
L.Zubcevic,
M.S.Sansom,
C.Vénien-Bryan,
and
S.J.Tucker
(2012).
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.
|
| |
Nat Struct Mol Biol,
19,
158-163.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Alam,
and
Y.Jiang
(2011).
Structural studies of ion selectivity in tetrameric cation channels.
|
| |
J Gen Physiol,
137,
397-403.
|
|
|
|
|
|
|
C.Boiteux,
and
S.Bernèche
(2011).
Absence of ion-binding affinity in the putatively inactivated low-[K+] structure of the KcsA potassium channel.
|
| |
Structure,
19,
70-79.
|
|
|
|
|
|
|
C.M.Nimigean,
and
T.W.Allen
(2011).
Origins of ion selectivity in potassium channels from the perspective of channel block.
|
| |
J Gen Physiol,
137,
405-413.
|
|
|
|
|
|
|
I.Waluyo,
C.Huang,
D.Nordlund,
U.Bergmann,
T.M.Weiss,
L.G.Pettersson,
and
A.Nilsson
(2011).
The structure of water in the hydration shell of cations from x-ray Raman and small angle x-ray scattering measurements.
|
| |
J Chem Phys,
134,
064513.
|
|
|
|
|
|
|
J.C.Pai,
J.A.Culver,
J.E.Drury,
R.S.Motani,
R.L.Lieberman,
and
J.A.Maynard
(2011).
Conversion of scFv peptide-binding specificity for crystal chaperone development.
|
| |
Protein Eng Des Sel,
24,
419-428.
|
|
|
|
|
|
|
L.Zúñiga,
V.Márquez,
F.D.González-Nilo,
C.Chipot,
L.P.Cid,
F.V.Sepúlveda,
and
M.I.Niemeyer
(2011).
Gating of a pH-Sensitive K(2P) Potassium Channel by an Electrostatic Effect of Basic Sensor Residues on the Selectivity Filter.
|
| |
PLoS One,
6,
e16141.
|
|
|
|
|
|
|
M.G.Derebe,
D.B.Sauer,
W.Zeng,
A.Alam,
N.Shi,
and
Y.Jiang
(2011).
Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites.
|
| |
Proc Natl Acad Sci U S A,
108,
598-602.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.G.Derebe,
W.Zeng,
Y.Li,
A.Alam,
and
Y.Jiang
(2011).
Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore.
|
| |
Proc Natl Acad Sci U S A,
108,
592-597.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
N.Monroe,
G.Sennhauser,
M.A.Seeger,
C.Briand,
and
M.G.Grütter
(2011).
Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface.
|
| |
J Struct Biol,
174,
269-281.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.D.Dixit,
and
D.Asthagiri
(2011).
Thermodynamics of ion selectivity in the KcsA K+ channel.
|
| |
J Gen Physiol,
137,
427-433.
|
|
|
|
|
|
|
P.Mitra,
and
D.Pal
(2011).
Combining Bayes classification and point group symmetry under Boolean framework for enhanced protein quaternary structure inference.
|
| |
Structure,
19,
304-312.
|
|
|
|
|
|
|
S.Chakrapani,
J.F.Cordero-Morales,
V.Jogini,
A.C.Pan,
D.M.Cortes,
B.Roux,
and
E.Perozo
(2011).
On the structural basis of modal gating behavior in K(+) channels.
|
| |
Nat Struct Mol Biol,
18,
67-74.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.A.Liu,
H.K.Chang,
and
R.C.Shieh
(2011).
Extracellular K(+) elevates outward currents through Kir2.1 channels by increasing single-channel conductance.
|
| |
Biochim Biophys Acta,
1808,
1772-1778.
|
|
|
|
|
|
|
V.Babin,
C.Roland,
and
C.Sagui
(2011).
The α-sheet: A missing-in-action secondary structure?
|
| |
Proteins,
79,
937-946.
|
|
|
|
|
|
|
W.W.Cheng,
J.G.McCoy,
A.N.Thompson,
C.G.Nichols,
and
C.M.Nimigean
(2011).
Mechanism for selectivity-inactivation coupling in KcsA potassium channels.
|
| |
Proc Natl Acad Sci U S A,
108,
5272-5277.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Y.Cao,
X.Jin,
H.Huang,
M.G.Derebe,
E.J.Levin,
V.Kabaleeswaran,
Y.Pan,
M.Punta,
J.Love,
J.Weng,
M.Quick,
S.Ye,
B.Kloss,
R.Bruni,
E.Martinez-Hackert,
W.A.Hendrickson,
B.Rost,
J.A.Javitch,
K.R.Rajashankar,
Y.Jiang,
and
M.Zhou
(2011).
Crystal structure of a potassium ion transporter, TrkH.
|
| |
Nature,
471,
336-340.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Anishkin,
A.L.Milac,
and
H.R.Guy
(2010).
Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels.
|
| |
Proteins,
78,
932-949.
|
|
|
|
|
|
|
A.Marsico,
K.Scheubert,
A.Tuukkanen,
A.Henschel,
C.Winter,
R.Winnenburg,
and
M.Schroeder
(2010).
MeMotif: a database of linear motifs in alpha-helical transmembrane proteins.
|
| |
Nucleic Acids Res,
38,
D181-D189.
|
|
|
|
|
|
|
A.Negoda,
E.Negoda,
and
R.N.Reusch
(2010).
Importance of oligo-R-3-hydroxybutyrates to S. lividans KcsA channel structure and function.
|
| |
Mol Biosyst,
6,
2249-2255.
|
|
|
|
|
|
|
A.S.Thomson,
and
B.S.Rothberg
(2010).
Voltage-dependent inactivation gating at the selectivity filter of the MthK K+ channel.
|
| |
J Gen Physiol,
136,
569-579.
|
|
|
|
|
|
|
C.Y.Lee,
W.Choi,
J.H.Han,
and
M.S.Strano
(2010).
Coherence resonance in a single-walled carbon nanotube ion channel.
|
| |
Science,
329,
1320-1324.
|
|
|
|
|
|
|
D.Rotem,
A.Mason,
and
H.Bayley
(2010).
Inactivation of the KcsA potassium channel explored with heterotetramers.
|
| |
J Gen Physiol,
135,
29-42.
|
|
|
|
|
|
|
E.D.Burg,
O.Platoshyn,
I.F.Tsigelny,
B.Lozano-Ruiz,
B.K.Rana,
and
J.X.Yuan
(2010).
Tetramerization domain mutations in KCNA5 affect channel kinetics and cause abnormal trafficking patterns.
|
| |
Am J Physiol Cell Physiol,
298,
C496-C509.
|
|
|
|
|
|
|
E.J.Denning,
and
T.B.Woolf
(2010).
Cooperative nature of gating transitions in K(+) channels as seen from dynamic importance sampling calculations.
|
| |
Proteins,
78,
1105-1119.
|
|
|
|
|
|
|
G.J.Bartlett,
A.Choudhary,
R.T.Raines,
and
D.N.Woolfson
(2010).
n-->pi* interactions in proteins.
|
| |
Nat Chem Biol,
6,
615-620.
|
|
|
|
|
|
|
H.Wu,
A.Canfield,
J.Adhikari,
and
S.Huo
(2010).
Quantum mechanical studies on model alpha-pleated sheets.
|
| |
J Comput Chem,
31,
1216-1223.
|
|
|
|
|
|
|
H.Yu,
S.Y.Noskov,
and
B.Roux
(2010).
Two mechanisms of ion selectivity in protein binding sites.
|
| |
Proc Natl Acad Sci U S A,
107,
20329-20334.
|
|
|
|
|
|
|
I.Maslennikov,
C.Klammt,
E.Hwang,
G.Kefala,
M.Okamura,
L.Esquivies,
K.Mörs,
C.Glaubitz,
W.Kwiatkowski,
Y.H.Jeon,
and
S.Choe
(2010).
Membrane domain structures of three classes of histidine kinase receptors by cell-free expression and rapid NMR analysis.
|
| |
Proc Natl Acad Sci U S A,
107,
10902-10907.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.A.Cieslak,
P.J.Focia,
and
A.Gross
(2010).
Electron spin-echo envelope modulation (ESEEM) reveals water and phosphate interactions with the KcsA potassium channel.
|
| |
Biochemistry,
49,
1486-1494.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.K.Lee,
and
R.M.Stroud
(2010).
Unlocking the eukaryotic membrane protein structural proteome.
|
| |
Curr Opin Struct Biol,
20,
464-470.
|
|
|
|
|
|
|
J.M.Kielec,
K.G.Valentine,
and
A.J.Wand
(2010).
A method for solution NMR structural studies of large integral membrane proteins: reverse micelle encapsulation.
|
| |
Biochim Biophys Acta,
1798,
150-160.
|
|
|
|
|
|
|
K.M.Thai,
A.Windisch,
D.Stork,
A.Weinzinger,
A.Schiesaro,
R.H.Guy,
E.N.Timin,
S.Hering,
and
G.F.Ecker
(2010).
The hERG potassium channel and drug trapping: insight from docking studies with propafenone derivatives.
|
| |
ChemMedChem,
5,
436-442.
|
|
|
|
|
|
|
K.McLuskey,
A.W.Roszak,
Y.Zhu,
and
N.W.Isaacs
(2010).
Crystal structures of all-alpha type membrane proteins.
|
| |
Eur Biophys J,
39,
723-755.
|
|
|
|
|
|
|
K.R.Vinothkumar,
and
R.Henderson
(2010).
Structures of membrane proteins.
|
| |
Q Rev Biophys,
43,
65.
|
|
|
|
|
|
|
K.Yoshimura,
and
M.Sokabe
(2010).
Mechanosensitivity of ion channels based on protein-lipid interactions.
|
| |
J R Soc Interface,
7,
S307-S320.
|
|
|
|
|
|
|
L.Dai,
V.Garg,
and
M.C.Sanguinetti
(2010).
Activation of Slo2.1 channels by niflumic acid.
|
| |
J Gen Physiol,
135,
275-295.
|
|
|
|
|
|
|
L.G.Cuello,
D.M.Cortes,
V.Jogini,
A.Sompornpisut,
and
E.Perozo
(2010).
A molecular mechanism for proton-dependent gating in KcsA.
|
| |
FEBS Lett,
584,
1126-1132.
|
|
|
|
|
|
|
L.G.Cuello,
V.Jogini,
D.M.Cortes,
A.C.Pan,
D.G.Gagnon,
O.Dalmas,
J.F.Cordero-Morales,
S.Chakrapani,
B.Roux,
and
E.Perozo
(2010).
Structural basis for the coupling between activation and inactivation gates in K(+) channels.
|
| |
Nature,
466,
272-275.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.G.Cuello,
V.Jogini,
D.M.Cortes,
A.Sompornpisut,
M.D.Purdy,
M.C.Wiener,
and
E.Perozo
(2010).
Design and characterization of a constitutively open KcsA.
|
| |
FEBS Lett,
584,
1133-1138.
|
|
|
|
|
|
|
L.G.Cuello,
V.Jogini,
D.M.Cortes,
and
E.Perozo
(2010).
Structural mechanism of C-type inactivation in K(+) channels.
|
| |
Nature,
466,
203-208.
|
|
|
|
|
|
|
M.Li,
T.Kawate,
S.D.Silberberg,
and
K.J.Swartz
(2010).
Pore-opening mechanism in trimeric P2X receptor channels.
|
| |
Nat Commun,
1,
1-7.
|
|
|
|
|
|
|
M.Mazzolini,
A.Marchesi,
A.Giorgetti,
and
V.Torre
(2010).
Gating in CNGA1 channels.
|
| |
Pflugers Arch,
459,
547-555.
|
|
|
|
|
|
|
M.R.Doddareddy,
E.C.Klaasse,
Shagufta,
A.P.Ijzerman,
and
A.Bender
(2010).
Prospective validation of a comprehensive in silico hERG model and its applications to commercial compound and drug databases.
|
| |
ChemMedChem,
5,
716-729.
|
|
|
|
|
|
|
M.Ă..Jensen,
D.W.Borhani,
K.Lindorff-Larsen,
P.Maragakis,
V.Jogini,
M.P.Eastwood,
R.O.Dror,
and
D.E.Shaw
(2010).
Principles of conduction and hydrophobic gating in K+ channels.
|
| |
Proc Natl Acad Sci U S A,
107,
5833-5838.
|
|
|
|
|
|
|
O.B.Clarke,
A.T.Caputo,
A.P.Hill,
J.I.Vandenberg,
B.J.Smith,
and
J.M.Gulbis
(2010).
Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels.
|
| |
Cell,
141,
1018-1029.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
P.J.Focke,
and
F.I.Valiyaveetil
(2010).
Studies of ion channels using expressed protein ligation.
|
| |
Curr Opin Chem Biol,
14,
797-802.
|
|
|
|
|
|
|
P.Sundaram,
W.M.Wells,
R.V.Mulkern,
E.J.Bubrick,
E.B.Bromfield,
M.Münch,
and
D.B.Orbach
(2010).
Fast human brain magnetic resonance responses associated with epileptiform spikes.
|
| |
Magn Reson Med,
64,
1728-1738.
|
|
|
|
|
|
|
R.Cervenka,
T.Zarrabi,
P.Lukacs,
and
H.Todt
(2010).
The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating.
|
| |
Mar Drugs,
8,
1373-1393.
|
|
|
|
|
|
|
R.S.Norton,
and
J.M.Gulbis
(2010).
Potassium channel gating: not an open and shut case.
|
| |
Proc Natl Acad Sci U S A,
107,
7623-7624.
|
|
|
|
|
|
|
S.Imai,
M.Osawa,
K.Takeuchi,
and
I.Shimada
(2010).
Structural basis underlying the dual gate properties of KcsA.
|
| |
Proc Natl Acad Sci U S A,
107,
6216-6221.
|
|
|
|
|
|
|
S.J.Stahl,
N.R.Watts,
C.Rader,
M.A.DiMattia,
R.G.Mage,
I.Palmer,
J.D.Kaufman,
J.M.Grimes,
D.I.Stuart,
A.C.Steven,
and
P.T.Wingfield
(2010).
Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev.
|
| |
J Mol Biol,
397,
697-708.
|
|
|
|
|
|
|
S.M.Sine,
H.L.Wang,
S.Hansen,
and
P.Taylor
(2010).
On the origin of ion selectivity in the Cys-loop receptor family.
|
| |
J Mol Neurosci,
40,
70-76.
|
|
|
|
|
|
|
S.Weyand,
and
S.Iwata
(2010).
Biochemistry. Old gate gets a new look.
|
| |
Science,
329,
151-152.
|
|
|
|
|
|
|
S.Ye,
Y.Li,
and
Y.Jiang
(2010).
Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore.
|
| |
Nat Struct Mol Biol,
17,
1019-1023.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.Zarrabi,
R.Cervenka,
W.Sandtner,
P.Lukacs,
X.Koenig,
K.Hilber,
M.Mille,
G.M.Lipkind,
H.A.Fozzard,
and
H.Todt
(2010).
A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.
|
| |
J Biol Chem,
285,
39458-39470.
|
|
|
|
|
|
|
Z.S.Siwy,
and
S.Howorka
(2010).
Engineered voltage-responsive nanopores.
|
| |
Chem Soc Rev,
39,
1115-1132.
|
|
|
|
|
|
|
A.Alam,
and
Y.Jiang
(2009).
Structural analysis of ion selectivity in the NaK channel.
|
| |
Nat Struct Mol Biol,
16,
35-41.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.Alam,
and
Y.Jiang
(2009).
High-resolution structure of the open NaK channel.
|
| |
Nat Struct Mol Biol,
16,
30-34.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.B.Tobin
(2009).
G-protein-coupled receptor structure: what can we learn?
|
| |
F1000 Biol Rep,
1,
0.
|
|
|
|
|
|
|
A.G.Komarov,
K.M.Linn,
J.J.Devereaux,
and
F.I.Valiyaveetil
(2009).
Modular strategy for the semisynthesis of a K+ channel: investigating interactions of the pore helix.
|
| |
ACS Chem Biol,
4,
1029-1038.
|
|
|
|
|
|
|
A.Kollewe,
A.Y.Lau,
A.Sullivan,
Benoît Roux,
and
S.A.Goldstein
(2009).
A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics.
|
| |
J Gen Physiol,
134,
53-68.
|
|
|
|
|
|
|
A.N.Thompson,
I.Kim,
T.D.Panosian,
T.M.Iverson,
T.W.Allen,
and
C.M.Nimigean
(2009).
Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore.
|
| |
Nat Struct Mol Biol,
16,
1317-1324.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
B.Endeward,
J.A.Butterwick,
R.MacKinnon,
and
T.F.Prisner
(2009).
Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA.
|
| |
J Am Chem Soc,
131,
15246-15250.
|
|
|
|
|
|
|
B.Liu,
J.Yao,
Y.Wang,
H.Li,
and
F.Qin
(2009).
Proton inhibition of unitary currents of vanilloid receptors.
|
| |
J Gen Physiol,
134,
243-258.
|
|
|
|
|
|
|
B.Wu,
C.Steinbronn,
M.Alsterfjord,
T.Zeuthen,
and
E.Beitz
(2009).
Concerted action of two cation filters in the aquaporin water channel.
|
| |
EMBO J,
28,
2188-2194.
|
|
|
|
|
|
|
C.A.Ahern,
and
W.R.Kobertz
(2009).
Chemical tools for K(+) channel biology.
|
| |
Biochemistry,
48,
517-526.
|
|
|
|
|
|
|
C.Ader,
R.Schneider,
S.Hornig,
P.Velisetty,
V.Vardanyan,
K.Giller,
I.Ohmert,
S.Becker,
O.Pongs,
and
M.Baldus
(2009).
Coupling of activation and inactivation gate in a K+-channel: potassium and ligand sensitivity.
|
| |
EMBO J,
28,
2825-2834.
|
|
|
|
|
|
|
C.Chaudhry,
A.J.Plested,
P.Schuck,
and
M.L.Mayer
(2009).
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions.
|
| |
Proc Natl Acad Sci U S A,
106,
12329-12334.
|
|
|
|
|
|
|
D.C.Gadsby
(2009).
Ion channels versus ion pumps: the principal difference, in principle.
|
| |
Nat Rev Mol Cell Biol,
10,
344-352.
|
|
|
|
|
|
|
D.L.Bostick,
and
C.L.Brooks
(2009).
Statistical determinants of selective ionic complexation: ions in solvent, transport proteins, and other "hosts".
|
| |
Biophys J,
96,
4470-4492.
|
|
|
|
|
|
|
E.Abad,
J.Reingruber,
and
M.S.Sansom
(2009).
On a novel rate theory for transport in narrow ion channels and its application to the study of flux optimization via geometric effects.
|
| |
J Chem Phys,
130,
085101.
|
|
|
|
|
|
|
E.B.Gonzales,
T.Kawate,
and
E.Gouaux
(2009).
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors.
|
| |
Nature,
460,
599-604.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
E.C.Minnihan,
K.Yokoyama,
and
J.Stubbe
(2009).
Unnatural amino acids: better than the real things?
|
| |
F1000 Biol Rep,
1,
0.
|
|
|
|
|
|
|
F.C.Chatelain,
S.Gazzarrini,
Y.Fujiwara,
C.Arrigoni,
C.Domigan,
G.Ferrara,
C.Pantoja,
G.Thiel,
A.Moroni,
and
D.L.Minor
(2009).
Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.
|
| |
PLoS One,
4,
e7496.
|
|
|
|
|
|
|
G.M.Clayton,
S.G.Aller,
J.Wang,
V.Unger,
and
J.H.Morais-Cabral
(2009).
Combining electron crystallography and X-ray crystallography to study the MlotiK1 cyclic nucleotide-regulated potassium channel.
|
| |
J Struct Biol,
167,
220-226.
|
|
|
|
|
|
|
H.R.Dahmani,
P.Schneeberger,
and
I.M.Kramer
(2009).
Analysis of students' aptitude to provide meaning to images that represent cellular components at the molecular level.
|
| |
CBE Life Sci Educ,
8,
226-238.
|
|
|
|
|
|
|
H.Yu,
S.Y.Noskov,
and
B.Roux
(2009).
Hydration number, topological control, and ion selectivity.
|
| |
J Phys Chem B,
113,
8725-8730.
|
|
|
|
|
|
|
I.Grunwald,
K.Rischka,
S.M.Kast,
T.Scheibel,
and
H.Bargel
(2009).
Mimicking biopolymers on a molecular scale: nano(bio)technology based on engineered proteins.
|
| |
Philos Transact A Math Phys Eng Sci,
367,
1727-1747.
|
|
|
|
|
|
|
J.L.Neira
(2009).
The positively charged C-terminal region of the inactivating Shaker B peptide binds to the potassium channel KcsA.
|
| |
Protein Eng Des Sel,
22,
341-347.
|
|
|
|
|
|
|
J.P.Newstadt,
D.J.Mayo,
J.J.Inbaraj,
N.Subbaraman,
and
G.A.Lorigan
(2009).
Determining the helical tilt of membrane peptides using electron paramagnetic resonance spectroscopy.
|
| |
J Magn Reson,
198,
1-7.
|
|
|
|
|
|
|
J.R.Martínez-François,
Y.Xu,
and
Z.Lu
(2009).
Mutations reveal voltage gating of CNGA1 channels in saturating cGMP.
|
| |
J Gen Physiol,
134,
151-164.
|
|
|
|
|
|
|
L.Wang,
A.T.Dennis,
P.Trieu,
F.Charron,
N.Ethier,
T.E.Hebert,
X.Wan,
and
E.Ficker
(2009).
Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.
|
| |
Mol Pharmacol,
75,
927-937.
|
|
|
|
|
|
|
M.H.Cheng,
Y.Xu,
and
P.Tang
(2009).
Anionic lipid and cholesterol interactions with alpha4beta2 nAChR: insights from MD simulations.
|
| |
J Phys Chem B,
113,
6964-6970.
|
|
|
|
|
|
|
M.Kudrnac,
S.Beyl,
A.Hohaus,
A.Stary,
T.Peterbauer,
E.Timin,
and
S.Hering
(2009).
Coupled and Independent Contributions of Residues in IS6 and IIS6 to Activation Gating of CaV1.2.
|
| |
J Biol Chem,
284,
12276-12284.
|
|
|
|
|
|
|
M.Mazzolini,
C.Anselmi,
and
V.Torre
(2009).
The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating.
|
| |
J Gen Physiol,
133,
375-386.
|
|
|
|
|
|
|
M.Pellegrini-Calace,
T.Maiwald,
and
J.M.Thornton
(2009).
PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure.
|
| |
PLoS Comput Biol,
5,
e1000440.
|
|
|
|
|
|
|
N.D'Avanzo,
R.Pekhletski,
and
P.H.Backx
(2009).
P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.
|
| |
PLoS One,
4,
e7712.
|
|
|
|
|
|
|
N.Y.Yount,
D.Kupferwasser,
A.Spisni,
S.M.Dutz,
Z.H.Ramjan,
S.Sharma,
A.J.Waring,
and
M.R.Yeaman
(2009).
Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine.
|
| |
Proc Natl Acad Sci U S A,
106,
14972-14977.
|
|
|
|
|
|
|
P.C.Chen,
and
S.Kuyucak
(2009).
Mechanism and energetics of charybdotoxin unbinding from a potassium channel from molecular dynamics simulations.
|
| |
Biophys J,
96,
2577-2588.
|
|
|
|
|
|
|
P.D.Dixit,
S.Merchant,
and
D.Asthagiri
(2009).
Ion selectivity in the KcsA potassium channel from the perspective of the ion binding site.
|
| |
Biophys J,
96,
2138-2145.
|
|
|
|
|
|
|
P.Gajdanowicz,
C.Garcia-Mata,
W.Gonzalez,
S.E.Morales-Navarro,
T.Sharma,
F.D.González-Nilo,
J.Gutowicz,
B.Mueller-Roeber,
M.R.Blatt,
and
I.Dreyer
(2009).
Distinct roles of the last transmembrane domain in controlling Arabidopsis K+ channel activity.
|
| |
New Phytol,
182,
380-391.
|
|
|
|
|
|
|
R.J.Hilf,
and
R.Dutzler
(2009).
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.
|
| |
Nature,
457,
115-118.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.Latorre,
C.Zaelzer,
and
S.Brauchi
(2009).
Structure-functional intimacies of transient receptor potential channels.
|
| |
Q Rev Biophys,
42,
201-246.
|
|
|
|
|
|
|
R.Oliva,
J.M.Thornton,
and
M.Pellegrini-Calace
(2009).
PoreLogo: a new tool to analyse, visualize and compare channels in transmembrane proteins.
|
| |
Bioinformatics,
25,
3183-3184.
|
|
|
|
|
|
|
S.Beyl,
P.Kügler,
M.Kudrnac,
A.Hohaus,
S.Hering,
and
E.Timin
(2009).
Different pathways for activation and deactivation in CaV1.2: a minimal gating model.
|
| |
J Gen Physiol,
134,
231.
|
|
|
|
|
|
|
S.Furini,
and
C.Domene
(2009).
Atypical mechanism of conduction in potassium channels.
|
| |
Proc Natl Acad Sci U S A,
106,
16074-16077.
|
|
|
|
|
|
|
S.Furini,
O.Beckstein,
and
C.Domene
(2009).
Permeation of water through the KcsA K+ channel.
|
| |
Proteins,
74,
437-448.
|
|
|
|
|
|
|
S.Koide
(2009).
Engineering of recombinant crystallization chaperones.
|
| |
Curr Opin Struct Biol,
19,
449-457.
|
|
|
|
|
|
|
S.Kraszewski,
C.Boiteux,
C.Ramseyer,
and
C.Girardet
(2009).
Determination of the charge profile in the KcsA selectivity filter using ab initio calculations and molecular dynamics simulations.
|
| |
Phys Chem Chem Phys,
11,
8606-8613.
|
|
|
|
|
|
|
S.Roy,
and
R.Llinás
(2009).
Relevance of quantum mechanics on some aspects of ion channel function.
|
| |
C R Biol,
332,
517-522.
|
|
|
|
|
|
|
S.Tayefeh,
T.Kloss,
M.Kreim,
M.Gebhardt,
D.Baumeister,
B.Hertel,
C.Richter,
H.Schwalbe,
A.Moroni,
G.Thiel,
and
S.M.Kast
(2009).
Model development for the viral Kcv potassium channel.
|
| |
Biophys J,
96,
485-498.
|
|
|
|
|
|
|
S.Uysal,
V.Vásquez,
V.Tereshko,
K.Esaki,
F.A.Fellouse,
S.S.Sidhu,
S.Koide,
E.Perozo,
and
A.Kossiakoff
(2009).
Crystal structure of full-length KcsA in its closed conformation.
|
| |
Proc Natl Acad Sci U S A,
106,
6644-6649.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Wang,
Y.Alimi,
A.Tong,
C.G.Nichols,
and
D.Enkvetchakul
(2009).
Differential roles of blocking ions in KirBac1.1 tetramer stability.
|
| |
J Biol Chem,
284,
2854-2860.
|
|
|
|
|
|
|
T.BaĆtuÄ,
and
S.Kuyucak
(2009).
Importance of the peptide backbone description in modeling the selectivity filter in potassium channels.
|
| |
Biophys J,
96,
4006-4012.
|
|
|
|
|
|
|
T.M.Blois,
and
J.U.Bowie
(2009).
G-protein-coupled receptor structures were not built in a day.
|
| |
Protein Sci,
18,
1335-1342.
|
|
|
|
|
|
|
T.Tsuda,
and
C.Toyoshima
(2009).
Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase.
|
| |
EMBO J,
28,
1782-1791.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
X.Tao,
J.L.Avalos,
J.Chen,
and
R.MacKinnon
(2009).
Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution.
|
| |
Science,
326,
1668-1674.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
Z.Yuchi,
V.P.Pau,
B.X.Lu,
M.Junop,
and
D.S.Yang
(2009).
An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel.
|
| |
FEBS J,
276,
6236-6246.
|
|
|
|
|
|
|
A.Enosh,
B.Raveh,
O.Furman-Schueler,
D.Halperin,
and
N.Ben-Tal
(2008).
Generation, comparison, and merging of pathways between protein conformations: gating in K-channels.
|
| |
Biophys J,
95,
3850-3860.
|
|
|
|
|
|
|
A.Roller,
G.Natura,
H.Bihler,
C.L.Slayman,
and
A.Bertl
(2008).
Functional consequences of leucine and tyrosine mutations in the dual pore motifs of the yeast K(+) channel, Tok1p.
|
| |
Pflugers Arch,
456,
883-896.
|
|
|
|
|
|
|
B.Adair,
R.Nunn,
S.Lewis,
I.Dukes,
L.Philipson,
and
M.Yeager
(2008).
Single particle image reconstruction of the human recombinant Kv2.1 channel.
|
| |
Biophys J,
94,
2106-2114.
|
|
|
|
|
|
|
B.Martinac,
Y.Saimi,
and
C.Kung
(2008).
Ion channels in microbes.
|
| |
Physiol Rev,
88,
1449-1490.
|
|
|
|
|
|
|
B.R.Myers,
C.J.Bohlen,
and
D.Julius
(2008).
A yeast genetic screen reveals a critical role for the pore helix domain in TRP channel gating.
|
| |
Neuron,
58,
362-373.
|
|
|
|
|
|
|
C.Ader,
R.Schneider,
S.Hornig,
P.Velisetty,
E.M.Wilson,
A.Lange,
K.Giller,
I.Ohmert,
M.F.Martin-Eauclaire,
D.Trauner,
S.Becker,
O.Pongs,
and
M.Baldus
(2008).
A structural link between inactivation and block of a K+ channel.
|
| |
Nat Struct Mol Biol,
15,
605-612.
|
|
|
|
|
|
|
C.Beeton,
B.J.Smith,
J.K.Sabo,
G.Crossley,
D.Nugent,
I.Khaytin,
V.Chi,
K.G.Chandy,
M.W.Pennington,
and
R.S.Norton
(2008).
The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.
|
| |
J Biol Chem,
283,
988-997.
|
|
|
|
|
|
|
C.Kramer,
B.Beck,
J.M.Kriegl,
and
T.Clark
(2008).
A composite model for HERG blockade.
|
| |
ChemMedChem,
3,
254-265.
|
|
|
|
|
|
|
D.Ma,
T.S.Tillman,
P.Tang,
E.Meirovitch,
R.Eckenhoff,
A.Carnini,
and
Y.Xu
(2008).
NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA.
|
| |
Proc Natl Acad Sci U S A,
105,
16537-16542.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
D.Zhan,
F.R.Fan,
and
A.J.Bard
(2008).
The Kv channel blocker 4-aminopyridine enhances Ag+ uptake: a scanning electrochemical microscopy study of single living cells.
|
| |
Proc Natl Acad Sci U S A,
105,
12118-12122.
|
|
|
|
|
|
|
E.P.Carpenter,
K.Beis,
A.D.Cameron,
and
S.Iwata
(2008).
Overcoming the challenges of membrane protein crystallography.
|
| |
Curr Opin Struct Biol,
18,
581-586.
|
|
|
|
|
|
|
F.T.Horrigan,
and
T.Hoshi
(2008).
Integration of an electric-metal sensory experience in the Slo1 BK channel.
|
| |
Nat Struct Mol Biol,
15,
1130-1132.
|
|
|
|
|
|
|
G.M.Clayton,
S.Altieri,
L.Heginbotham,
V.M.Unger,
and
J.H.Morais-Cabral
(2008).
Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel.
|
| |
Proc Natl Acad Sci U S A,
105,
1511-1515.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
G.Portella,
J.S.Hub,
M.D.Vesper,
and
B.L.de Groot
(2008).
Not only enthalpy: large entropy contribution to ion permeation barriers in single-file channels.
|
| |
Biophys J,
95,
2275-2282.
|
|
|
|
|
|
|
G.V.Miloshevsky,
and
P.C.Jordan
(2008).
Conformational changes in the selectivity filter of the open-state KcsA channel: an energy minimization study.
|
| |
Biophys J,
95,
3239-3251.
|
|
|
|
|
|
|
H.Wulff,
and
B.S.Zhorov
(2008).
K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.
|
| |
Chem Rev,
108,
1744-1773.
|
|
|
|
|
|
|
I.V.Khavrutskii,
M.Fajer,
and
J.A.McCammon
(2008).
Intrinsic Free Energy of the Conformational Transition of the KcsA Signature Peptide from Conducting to Nonconducting State.
|
| |
J Chem Theory Comput,
4,
1541-1554.
|
|
|
|
|
|
|
J.E.Contreras,
D.Srikumar,
and
M.Holmgren
(2008).
Gating at the selectivity filter in cyclic nucleotide-gated channels.
|
| |
Proc Natl Acad Sci U S A,
105,
3310-3314.
|
|
|
|
|
|
|
J.J.Paynter,
P.Sarkies,
I.Andres-Enguix,
and
S.J.Tucker
(2008).
Genetic selection of activatory mutations in KcsA.
|
| |
Channels (Austin),
2,
413-418.
|
|
|
|
|
|
|
J.L.Robertson,
L.G.Palmer,
and
B.Roux
(2008).
Long-pore electrostatics in inward-rectifier potassium channels.
|
| |
J Gen Physiol,
132,
613-632.
|
|
|
|
|
|
|
J.R.Clay,
D.Paydarfar,
and
D.B.Forger
(2008).
A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons.
|
| |
J R Soc Interface,
5,
1421-1428.
|
|
|
|
|
|
|
J.S.Santos,
S.M.Grigoriev,
and
M.Montal
(2008).
Molecular template for a voltage sensor in a novel K+ channel. III. Functional reconstitution of a sensorless pore module from a prokaryotic Kv channel.
|
| |
J Gen Physiol,
132,
651-666.
|
|
|
|
|
|
|
K.M.Waldhauser,
K.Brecht,
S.Hebeisen,
H.R.Ha,
D.Konrad,
D.Bur,
and
S.Krähenbühl
(2008).
Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues.
|
| |
Br J Pharmacol,
155,
585-595.
|
|
|
|
|
|
|
K.MaĆysiak,
and
Z.J.Grzywna
(2008).
On the possible methods for the mathematical description of the ball and chain model of ion channel inactivation.
|
| |
Cell Mol Biol Lett,
13,
535-552.
|
|
|
|
|
|
|
M.Andér,
V.B.Luzhkov,
and
J.Aqvist
(2008).
Ligand binding to the voltage-gated Kv1.5 potassium channel in the open state--docking and computer simulations of a homology model.
|
| |
Biophys J,
94,
820-831.
|
|
|
|
|
|
|
M.Li,
T.H.Chang,
S.D.Silberberg,
and
K.J.Swartz
(2008).
Gating the pore of P2X receptor channels.
|
| |
Nat Neurosci,
11,
883-887.
|
|
|
|
|
|
|
M.Masetti,
A.Cavalli,
and
M.Recanatini
(2008).
Modeling the hERG potassium channel in a phospholipid bilayer: Molecular dynamics and drug docking studies.
|
| |
J Comput Chem,
29,
795-808.
|
|
|
|
|
|
|
N.Zandany,
M.Ovadia,
I.Orr,
and
O.Yifrach
(2008).
Direct analysis of cooperativity in multisubunit allosteric proteins.
|
| |
Proc Natl Acad Sci U S A,
105,
11697-11702.
|
|
|
|
|
|
|
O.Zaika,
C.C.Hernandez,
M.Bal,
G.P.Tolstykh,
and
M.S.Shapiro
(2008).
Determinants within the turret and pore-loop domains of KCNQ3 K+ channels governing functional activity.
|
| |
Biophys J,
95,
5121-5137.
|
|
|
|
|
|
|
P.Marius,
M.Zagnoni,
M.E.Sandison,
J.M.East,
H.Morgan,
and
A.G.Lee
(2008).
Binding of anionic lipids to at least three nonannular sites on the potassium channel KcsA is required for channel opening.
|
| |
Biophys J,
94,
1689-1698.
|
|
|
|
|
|
|
P.Sompornpisut,
B.Roux,
and
E.Perozo
(2008).
Structural refinement of membrane proteins by restrained molecular dynamics and solvent accessibility data.
|
| |
Biophys J,
95,
5349-5361.
|
|
|
|
|
|
|
P.W.Fowler,
K.Tai,
and
M.S.Sansom
(2008).
The selectivity of K+ ion channels: testing the hypotheses.
|
| |
Biophys J,
95,
5062-5072.
|
|
|
|
|
|
|
R.J.Hilf,
and
R.Dutzler
(2008).
X-ray structure of a prokaryotic pentameric ligand-gated ion channel.
|
| |
Nature,
452,
375-379.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.J.Law,
K.Munson,
G.Sachs,
and
F.C.Lightstone
(2008).
An ion gating mechanism of gastric H,K-ATPase based on molecular dynamics simulations.
|
| |
Biophys J,
95,
2739-2749.
|
|
|
|
|
|
|
R.J.Mashl,
and
E.Jakobsson
(2008).
End-point targeted molecular dynamics: large-scale conformational changes in potassium channels.
|
| |
Biophys J,
94,
4307-4319.
|
|
|
|
|
|
|
R.Roth,
D.Gillespie,
W.Nonner,
and
R.E.Eisenberg
(2008).
Bubbles, gating, and anesthetics in ion channels.
|
| |
Biophys J,
94,
4282-4298.
|
|
|
|
|
|
|
S.B.Hansen,
H.L.Wang,
P.Taylor,
and
S.M.Sine
(2008).
An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance.
|
| |
J Biol Chem,
283,
36066-36070.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Hayward,
and
E.J.Milner-White
(2008).
The geometry of alpha-sheet: Implications for its possible function as amyloid precursor in proteins.
|
| |
Proteins,
71,
415-425.
|
|
|
|
|
|
|
S.I.Börjesson,
and
F.Elinder
(2008).
Structure, function, and modification of the voltage sensor in voltage-gated ion channels.
|
| |
Cell Biochem Biophys,
52,
149-174.
|
|
|
|
|
|
|
S.Kraszewski,
S.O.Yesylevskyy,
C.Boiteux,
C.Ramseyer,
and
V.N.Kharkyanen
(2008).
Is the mobility of the pore walls and water molecules in the selectivity filter of KcsA channel functionally important?
|
| |
Phys Chem Chem Phys,
10,
2249-2255.
|
|
|
|
|
|
|
S.Somodi,
P.Hajdu,
R.Gáspár,
G.Panyi,
and
Z.Varga
(2008).
Effects of changes in extracellular pH and potassium concentration on Kv1.3 inactivation.
|
| |
Eur Biophys J,
37,
1145-1156.
|
|
|
|
|
|
|
S.Varma,
D.Sabo,
and
S.B.Rempe
(2008).
K+/Na+ selectivity in K channels and valinomycin: over-coordination versus cavity-size constraints.
|
| |
J Mol Biol,
376,
13-22.
|
|
|
|
|
|
|
S.Varma,
and
S.B.Rempe
(2008).
Structural transitions in ion coordination driven by changes in competition for ligand binding.
|
| |
J Am Chem Soc,
130,
15405-15419.
|
|
|
|
|
|
|
T.Haliloglu,
and
N.Ben-Tal
(2008).
Cooperative transition between open and closed conformations in potassium channels.
|
| |
PLoS Comput Biol,
4,
e1000164.
|
|
|
|
|
|
|
T.Karasawa,
Q.Wang,
Y.Fu,
D.M.Cohen,
and
P.S.Steyger
(2008).
TRPV4 enhances the cellular uptake of aminoglycoside antibiotics.
|
| |
J Cell Sci,
121,
2871-2879.
|
|
|
|
|
|
|
T.Vora,
B.Corry,
and
S.H.Chung
(2008).
Brownian dynamics study of flux ratios in sodium channels.
|
| |
Eur Biophys J,
38,
45-52.
|
|
|
|
|
|
|
T.Vora,
D.Bisset,
and
S.H.Chung
(2008).
Conduction of Na+ and K+ through the NaK channel: molecular and Brownian dynamics studies.
|
| |
Biophys J,
95,
1600-1611.
|
|
|
|
|
|
|
U.Zachariae,
R.Schneider,
P.Velisetty,
A.Lange,
D.Seeliger,
S.J.Wacker,
Y.Karimi-Nejad,
G.Vriend,
S.Becker,
O.Pongs,
M.Baldus,
and
B.L.de Groot
(2008).
The molecular mechanism of toxin-induced conformational changes in a potassium channel: relation to C-type inactivation.
|
| |
Structure,
16,
747-754.
|
|
|
|
|
|
|
V.González-Pérez,
A.Neely,
C.Tapia,
G.González-Gutiérrez,
G.Contreras,
P.Orio,
V.Lagos,
G.Rojas,
T.Estévez,
K.Stack,
and
D.Naranjo
(2008).
Slow inactivation in Shaker K channels is delayed by intracellular tetraethylammonium.
|
| |
J Gen Physiol,
132,
633-650.
|
|
|
|
|
|
|
X.Tao,
and
R.MacKinnon
(2008).
Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers.
|
| |
J Mol Biol,
382,
24-33.
|
|
|
|
|
|
|
Y.A.Kaulin,
J.A.De Santiago-Castillo,
C.A.Rocha,
and
M.Covarrubias
(2008).
Mechanism of the modulation of Kv4:KChIP-1 channels by external K+.
|
| |
Biophys J,
94,
1241-1251.
|
|
|
|
|
|
|
Y.Shafrir,
S.R.Durell,
and
H.R.Guy
(2008).
Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel.
|
| |
Biophys J,
95,
3650-3662.
|
|
|
|
|
|
|
A.Bruening-Wright,
W.S.Lee,
J.P.Adelman,
and
J.Maylie
(2007).
Evidence for a deep pore activation gate in small conductance Ca2+-activated K+ channels.
|
| |
J Gen Physiol,
130,
601-610.
|
|
|
|
|
|
|
A.DamjanoviÄ,
J.L.Schlessman,
C.A.Fitch,
A.E.García,
and
B.García-Moreno E
(2007).
Role of flexibility and polarity as determinants of the hydration of internal cavities and pockets in proteins.
|
| |
Biophys J,
93,
2791-2804.
|
|
|
|
|
|
|
A.Latz,
D.Becker,
M.Hekman,
T.Müller,
D.Beyhl,
I.Marten,
C.Eing,
A.Fischer,
M.Dunkel,
A.Bertl,
U.R.Rapp,
and
R.Hedrich
(2007).
TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins.
|
| |
Plant J,
52,
449-459.
|
|
|
|
|
|
|
C.Anselmi,
P.Carloni,
and
V.Torre
(2007).
Origin of functional diversity among tetrameric voltage-gated channels.
|
| |
Proteins,
66,
136-146.
|
|
|
|
|
|
|
C.Boiteux,
S.Kraszewski,
C.Ramseyer,
and
C.Girardet
(2007).
Ion conductance vs. pore gating and selectivity in KcsA channel: modeling achievements and perspectives.
|
| |
J Mol Model,
13,
699-713.
|
|
|
|
|
|
|
C.M.Armstrong
(2007).
Life among the axons.
|
| |
Annu Rev Physiol,
69,
1.
|
|
|
|
|
|
|
D.B.Tikhonov,
and
B.S.Zhorov
(2007).
Sodium channels: ionic model of slow inactivation and state-dependent drug binding.
|
| |
Biophys J,
93,
1557-1570.
|
|
|
|
|
|
|
D.Bucher,
L.Guidoni,
and
U.Rothlisberger
(2007).
The protonation state of the Glu-71/Asp-80 residues in the KcsA potassium channel: a first-principles QM/MM molecular dynamics study.
|
| |
Biophys J,
93,
2315-2324.
|
|
|
|
|
|
|
D.L.Bostick,
and
C.L.Brooks
(2007).
Selectivity in K+ channels is due to topological control of the permeant ion's coordinated state.
|
| |
Proc Natl Acad Sci U S A,
104,
9260-9265.
|
|
|
|
|
|
|
D.L.Minor
(2007).
The neurobiologist's guide to structural biology: a primer on why macromolecular structure matters and how to evaluate structural data.
|
| |
Neuron,
54,
511-533.
|
|
|
|
|
|
|
E.Sadovsky,
and
O.Yifrach
(2007).
Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel.
|
| |
Proc Natl Acad Sci U S A,
104,
19813-19818.
|
|
|
|
|
|
|
F.Gómez-Lagunas
(2007).
Stability of the Shab K+ channel conductance in 0 K+ solutions: the role of the membrane potential.
|
| |
Biophys J,
93,
4197-4208.
|
|
|
|
|
|
|
F.Mancia,
S.Brenner-Morton,
R.Siegel,
Z.Assur,
Y.Sun,
I.Schieren,
M.Mendelsohn,
R.Axel,
and
W.A.Hendrickson
(2007).
Production and characterization of monoclonal antibodies sensitive to conformation in the 5HT2c serotonin receptor.
|
| |
Proc Natl Acad Sci U S A,
104,
4303-4308.
|
|
|
|
|
|
|
F.Mancia,
and
W.A.Hendrickson
(2007).
Expression of recombinant G-protein coupled receptors for structural biology.
|
| |
Mol Biosyst,
3,
723-734.
|
|
|
|
|
|
|
G.Gibor,
D.Yakubovich,
A.Rosenhouse-Dantsker,
A.Peretz,
H.Schottelndreier,
G.Seebohm,
N.Dascal,
D.E.Logothetis,
Y.Paas,
and
B.Attali
(2007).
An inactivation gate in the selectivity filter of KCNQ1 potassium channels.
|
| |
Biophys J,
93,
4159-4172.
|
|
|
|
|
|
|
G.Panyi,
and
C.Deutsch
(2007).
Probing the cavity of the slow inactivated conformation of shaker potassium channels.
|
| |
J Gen Physiol,
129,
403-418.
|
|
|
|
|
|
|
G.V.Miloshevsky,
and
P.C.Jordan
(2007).
Open-state conformation of the KcsA K+ channel: Monte Carlo normal mode following simulations.
|
| |
Structure,
15,
1654-1662.
|
|
|
|
|
|
|
G.von Heijne
(2007).
The membrane protein universe: what's out there and why bother?
|
| |
J Intern Med,
261,
543-557.
|
|
|
|
|
|
|
I.Schroeder,
and
U.P.Hansen
(2007).
Saturation and microsecond gating of current indicate depletion-induced instability of the MaxiK selectivity filter.
|
| |
J Gen Physiol,
130,
83-97.
|
|
|
|
|
|
|
J.C.Greie,
and
K.Altendorf
(2007).
The K+-translocating KdpFABC complex from Escherichia coli: a P-type ATPase with unique features.
|
| |
J Bioenerg Biomembr,
39,
397-402.
|
|
|
|
|
|
|
J.F.Cordero-Morales,
V.Jogini,
A.Lewis,
V.Vásquez,
D.M.Cortes,
B.Roux,
and
E.Perozo
(2007).
Molecular driving forces determining potassium channel slow inactivation.
|
| |
Nat Struct Mol Biol,
14,
1062-1069.
|
|
|
|
|
|
|
J.F.Gwan,
and
A.Baumgaertner
(2007).
Cooperative transport in a potassium ion channel.
|
| |
J Chem Phys,
127,
045103.
|
|
|
|
|
|
|
J.H.Chill,
J.M.Louis,
F.Delaglio,
and
A.Bax
(2007).
Local and global structure of the monomeric subunit of the potassium channel KcsA probed by NMR.
|
| |
Biochim Biophys Acta,
1768,
3260-3270.
|
|
|
|
|
|
|
K.A.Baker,
C.Tzitzilonis,
W.Kwiatkowski,
S.Choe,
and
R.Riek
(2007).
Conformational dynamics of the KcsA potassium channel governs gating properties.
|
| |
Nat Struct Mol Biol,
14,
1089-1095.
|
|
|
|
|
|
|
K.Takeuchi,
H.Takahashi,
S.Kawano,
and
I.Shimada
(2007).
Identification and characterization of the slowly exchanging pH-dependent conformational rearrangement in KcsA.
|
| |
J Biol Chem,
282,
15179-15186.
|
|
|
|
|
|
|
M.Baldus
(2007).
Magnetic resonance in the solid state: applications to protein folding, amyloid fibrils and membrane proteins.
|
| |
Eur Biophys J,
36,
37-48.
|
|
|
|
|
|
|
M.Baldus
(2007).
ICMRBS founder's medal 2006: biological solid-state NMR, methods and applications.
|
| |
J Biomol NMR,
39,
73-86.
|
|
|
|
|
|
|
M.Fatehi,
C.N.St Aubin,
and
P.Linsdell
(2007).
On the origin of asymmetric interactions between permeant anions and the cystic fibrosis transmembrane conductance regulator chloride channel pore.
|
| |
Biophys J,
92,
1241-1253.
|
|
|
|
|
|
|
M.H.Cheng,
M.Cascio,
and
R.D.Coalson
(2007).
Homology modeling and molecular dynamics simulations of the alpha1 glycine receptor reveals different states of the channel.
|
| |
Proteins,
68,
581-593.
|
|
|
|
|
|
|
M.Hayashi,
and
H.Matsuda
(2007).
Negatively charged residues located near the external entrance are required for the Kir2.1 channel to function.
|
| |
Pflugers Arch,
455,
455-464.
|
|
|
|
|
|
|
M.Nishida,
M.Cadene,
B.T.Chait,
and
R.MacKinnon
(2007).
Crystal structure of a Kir3.1-prokaryotic Kir channel chimera.
|
| |
EMBO J,
26,
4005-4015.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.Thomas,
D.Jayatilaka,
and
B.Corry
(2007).
The predominant role of coordination number in potassium channel selectivity.
|
| |
Biophys J,
93,
2635-2643.
|
|
|
|
|
|
|
P.C.Jordan
(2007).
Tuning a potassium channel--the caress of the surroundings.
|
| |
Biophys J,
93,
1091-1092.
|
|
|
|
|
|
|
P.J.Stansfeld,
P.Gedeck,
M.Gosling,
B.Cox,
J.S.Mitcheson,
and
M.J.Sutcliffe
(2007).
Drug block of the hERG potassium channel: insight from modeling.
|
| |
Proteins,
68,
568-580.
|
|
|
|
|
|
|
R.A.Albright,
K.Joh,
and
J.H.Morais-Cabral
(2007).
Probing the structure of the dimeric KtrB membrane protein.
|
| |
J Biol Chem,
282,
35046-35055.
|
|
|
|
|
|
|
R.M.Hardman,
P.J.Stansfeld,
S.Dalibalta,
M.J.Sutcliffe,
and
J.S.Mitcheson
(2007).
Activation gating of hERG potassium channels: S6 glycines are not required as gating hinges.
|
| |
J Biol Chem,
282,
31972-31981.
|
|
|
|
|
|
|
S.B.Long,
X.Tao,
E.B.Campbell,
and
R.MacKinnon
(2007).
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.
|
| |
Nature,
450,
376-382.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.Chakrapani,
J.F.Cordero-Morales,
and
E.Perozo
(2007).
A quantitative description of KcsA gating I: macroscopic currents.
|
| |
J Gen Physiol,
130,
465-478.
|
|
|
|
|
|
|
S.Chakrapani,
J.F.Cordero-Morales,
and
E.Perozo
(2007).
A quantitative description of KcsA gating II: single-channel currents.
|
| |
J Gen Physiol,
130,
479-496.
|
|
|
|
|
|
|
S.F.Poget,
and
M.E.Girvin
(2007).
Solution NMR of membrane proteins in bilayer mimics: small is beautiful, but sometimes bigger is better.
|
| |
Biochim Biophys Acta,
1768,
3098-3106.
|
|
|
|
|
|
|
S.H.Chung,
and
B.Corry
(2007).
Conduction properties of KcsA measured using brownian dynamics with flexible carbonyl groups in the selectivity filter.
|
| |
Biophys J,
93,
44-53.
|
|
|
|
|
|
|
S.Kraszewski,
C.Boiteux,
M.Langner,
and
C.Ramseyer
(2007).
Insight into the origins of the barrier-less knock-on conduction in the KcsA channel: molecular dynamics simulations and ab initio calculations.
|
| |
Phys Chem Chem Phys,
9,
1219-1225.
|
|
|
|
|
|
|
S.Nauli,
S.Farr,
Y.J.Lee,
H.Y.Kim,
S.Faham,
and
J.U.Bowie
(2007).
Polymer-driven crystallization.
|
| |
Protein Sci,
16,
2542-2551.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Varma,
and
S.B.Rempe
(2007).
Tuning ion coordination architectures to enable selective partitioning.
|
| |
Biophys J,
93,
1093-1099.
|
|
|
|
|
|
|
S.W.Lockless,
M.Zhou,
and
R.MacKinnon
(2007).
Structural and thermodynamic properties of selective ion binding in a K+ channel.
|
| |
PLoS Biol,
5,
e121.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Y.Noskov,
and
B.Roux
(2007).
Importance of hydration and dynamics on the selectivity of the KcsA and NaK channels.
|
| |
J Gen Physiol,
129,
135-143.
|
|
|
|
|
|
|
T.BaĆtuÄ,
and
S.Kuyucak
(2007).
Free energy simulations of single and double ion occupancy in gramicidin A.
|
| |
J Chem Phys,
126,
105103.
|
|
|
|
|
|
|
T.Imai,
R.Hiraoka,
A.Kovalenko,
and
F.Hirata
(2007).
Locating missing water molecules in protein cavities by the three-dimensional reference interaction site model theory of molecular solvation.
|
| |
Proteins,
66,
804-813.
|
|
|
|
|
|
|
V.P.Pau,
Y.Zhu,
Z.Yuchi,
Q.Q.Hoang,
and
D.S.Yang
(2007).
Characterization of the C-terminal domain of a potassium channel from Streptomyces lividans (KcsA).
|
| |
J Biol Chem,
282,
29163-29169.
|
|
|
|
|
|
|
X.Chen,
B.K.Poon,
A.Dousis,
Q.Wang,
and
J.Ma
(2007).
Normal-mode refinement of anisotropic thermal parameters for potassium channel KcsA at 3.2 A crystallographic resolution.
|
| |
Structure,
15,
955-962.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
X.Liang,
D.J.Campopiano,
and
P.J.Sadler
(2007).
Metals in membranes.
|
| |
Chem Soc Rev,
36,
968-992.
|
|
|
|
|
|
|
Y.Li,
I.Berke,
L.Chen,
and
Y.Jiang
(2007).
Gating and inward rectifying properties of the MthK K+ channel with and without the gating ring.
|
| |
J Gen Physiol,
129,
109-120.
|
|
|
|
|
|
|
Y.Peng,
J.N.Scarsdale,
and
G.E.Kellogg
(2007).
Hydropathic analysis and comparison of KcsA and Shaker potassium channels.
|
| |
Chem Biodivers,
4,
2578-2592.
|
|
|
|
|
|
|
Z.Oláh,
K.Jósvay,
L.Pecze,
T.Letoha,
N.Babai,
D.Budai,
F.Otvös,
S.Szalma,
and
C.Vizler
(2007).
Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel.
|
| |
PLoS ONE,
2,
e545.
|
|
|
|
|
|
|
A.Lange,
K.Giller,
S.Hornig,
M.F.Martin-Eauclaire,
O.Pongs,
S.Becker,
and
M.Baldus
(2006).
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR.
|
| |
Nature,
440,
959-962.
|
|
|
|
|
|
|
A.Raybaud,
Y.Dodier,
P.Bissonnette,
M.Simoes,
D.G.Bichet,
R.Sauvé,
and
L.Parent
(2006).
The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.
|
| |
J Biol Chem,
281,
39424-39436.
|
|
|
|
|
|
|
A.V.Nair,
M.Mazzolini,
P.Codega,
A.Giorgetti,
and
V.Torre
(2006).
Locking CNGA1 channels in the open and closed state.
|
| |
Biophys J,
90,
3599-3607.
|
|
|
|
|
|
|
B.Corry
(2006).
Understanding ion channel selectivity and gating and their role in cellular signalling.
|
| |
Mol Biosyst,
2,
527-535.
|
|
|
|
|
|
|
C.A.Ahern,
A.L.Eastwood,
H.A.Lester,
D.A.Dougherty,
and
R.Horn
(2006).
A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels.
|
| |
J Gen Physiol,
128,
649-657.
|
|
|
|
|
|
|
C.C.Quinn,
and
T.Begenisich
(2006).
Pharmacology and surface electrostatics of the K channel outer pore vestibule.
|
| |
J Membr Biol,
212,
51-60.
|
|
|
|
|
|
|
C.Dong,
K.Beis,
J.Nesper,
A.L.Brunkan-Lamontagne,
B.R.Clarke,
C.Whitfield,
and
J.H.Naismith
(2006).
Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein.
|
| |
Nature,
444,
226-229.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.J.Miller,
and
J.M.Lisy
(2006).
Mimicking solvent shells in the gas phase. II. Solvation of K+.
|
| |
J Chem Phys,
124,
024319.
|
|
|
|
|
|
|
E.C.Ray,
and
C.Deutsch
(2006).
A trapped intracellular cation modulates K+ channel recovery from slow inactivation.
|
| |
J Gen Physiol,
128,
203-217.
|
|
|
|
|
|
|
F.I.Valiyaveetil,
M.Leonetti,
T.W.Muir,
and
R.Mackinnon
(2006).
Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation.
|
| |
Science,
314,
1004-1007.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
F.I.Valiyaveetil,
M.Sekedat,
R.MacKinnon,
and
T.W.Muir
(2006).
Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel.
|
| |
J Am Chem Soc,
128,
11591-11599.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
F.Khalili-Araghi,
E.Tajkhorshid,
and
K.Schulten
(2006).
Dynamics of K+ ion conduction through Kv1.2.
|
| |
Biophys J,
91,
L72-L74.
|
|
|
|
|
|
|
G.Owsianik,
K.Talavera,
T.Voets,
and
B.Nilius
(2006).
Permeation and selectivity of TRP channels.
|
| |
Annu Rev Physiol,
68,
685-717.
|
|
|
|
|
|
|
G.Panyi,
and
C.Deutsch
(2006).
Cross talk between activation and slow inactivation gates of Shaker potassium channels.
|
| |
J Gen Physiol,
128,
547-559.
|
|
|
|
|
|
|
H.Liu,
S.Murad,
and
C.J.Jameson
(2006).
Ion permeation dynamics in carbon nanotubes.
|
| |
J Chem Phys,
125,
084713.
|
|
|
|
|
|
|
H.Sackin,
M.Nanazashvili,
L.G.Palmer,
and
H.Li
(2006).
Role of conserved glycines in pH gating of Kir1.1 (ROMK).
|
| |
Biophys J,
90,
3582-3589.
|
|
|
|
|
|
|
H.W.de Haan,
I.S.Tolokh,
C.G.Gray,
and
S.Goldman
(2006).
Nonequilibrium molecular dynamics calculation of the conductance of the KcsA potassium ion channel.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys,
74,
030905.
|
|
|
|
|
|
|
I.H.Shrivastava,
and
I.Bahar
(2006).
Common mechanism of pore opening shared by five different potassium channels.
|
| |
Biophys J,
90,
3929-3940.
|
|
|
|
|
|
|
I.S.Tolokh,
S.Goldman,
and
C.G.Gray
(2006).
Unified modeling of conductance kinetics for low- and high-conductance potassium ion channels.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys,
74,
011902.
|
|
|
|
|
|
|
J.Bronson,
O.S.Lee,
and
J.G.Saven
(2006).
Molecular Dynamics Simulation of WSK-3, a Computationally Designed, Water-Soluble Variant of the Integral Membrane Protein KcsA.
|
| |
Biophys J,
90,
1156-1163.
|
|
|
|
|
|
|
J.E.Milner-White,
J.D.Watson,
G.Qi,
and
S.Hayward
(2006).
Amyloid formation may involve alpha- to beta sheet interconversion via peptide plane flipping.
|
| |
Structure,
14,
1369-1376.
|
|
|
|
|
|
|
J.F.Cordero-Morales,
L.G.Cuello,
and
E.Perozo
(2006).
Voltage-dependent gating at the KcsA selectivity filter.
|
| |
Nat Struct Mol Biol,
13,
319-322.
|
|
|
|
|
|
|
J.F.Cordero-Morales,
L.G.Cuello,
Y.Zhao,
V.Jogini,
D.M.Cortes,
B.Roux,
and
E.Perozo
(2006).
Molecular determinants of gating at the potassium-channel selectivity filter.
|
| |
Nat Struct Mol Biol,
13,
311-318.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.H.Chill,
J.M.Louis,
C.Miller,
and
A.Bax
(2006).
NMR study of the tetrameric KcsA potassium channel in detergent micelles.
|
| |
Protein Sci,
15,
684-698.
|
|
|
|
|
|
|
J.H.Chill,
J.M.Louis,
J.L.Baber,
and
A.Bax
(2006).
Measurement of 15N relaxation in the detergent-solubilized tetrameric KcsA potassium channel.
|
| |
J Biomol NMR,
36,
123-136.
|
|
|
|
|
|
|
J.Hoffmann,
A.Gorodetskaia,
and
M.Hollmann
(2006).
Ion pore properties of ionotropic glutamate receptors are modulated by a transplanted potassium channel selectivity filter.
|
| |
Mol Cell Neurosci,
33,
335-343.
|
|
|
|
|
|
|
J.Payandeh,
and
E.F.Pai
(2006).
A structural basis for Mg2+ homeostasis and the CorA translocation cycle.
|
| |
EMBO J,
25,
3762-3773.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.R.Pfeifer,
P.Reiss,
and
U.Koert
(2006).
Crown ether-gramicidin hybrid ion channels: dehydration-assisted ion selectivity.
|
| |
Angew Chem Int Ed Engl,
45,
501-504.
|
|
|
|
|
|
|
J.Zimmer,
D.A.Doyle,
and
J.G.Grossmann
(2006).
Structural characterization and pH-induced conformational transition of full-length KcsA.
|
| |
Biophys J,
90,
1752-1766.
|
|
|
|
|
|
|
M.C.Sanguinetti,
and
M.Tristani-Firouzi
(2006).
hERG potassium channels and cardiac arrhythmia.
|
| |
Nature,
440,
463-469.
|
|
|
|
|
|
|
M.Grabe,
D.Bichet,
X.Qian,
Y.N.Jan,
and
L.Y.Jan
(2006).
K+ channel selectivity depends on kinetic as well as thermodynamic factors.
|
| |
Proc Natl Acad Sci U S A,
103,
14361-14366.
|
|
|
|
|
|
|
M.L.Chapman,
M.L.Blanke,
H.S.Krovetz,
and
A.M.Vandongen
(2006).
Allosteric effects of external K(+) ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K(+) channel.
|
| |
Pflugers Arch,
451,
776-792.
|
|
|
|
|
|
|
M.L.Molina,
F.N.Barrera,
A.M.Fernández,
J.A.Poveda,
M.L.Renart,
J.A.Encinar,
G.Riquelme,
and
J.M.González-Ros
(2006).
Clustering and coupled gating modulate the activity in KcsA, a potassium channel model.
|
| |
J Biol Chem,
281,
18837-18848.
|
|
|
|
|
|
|
M.L.Renart,
F.N.Barrera,
M.L.Molina,
J.A.Encinar,
J.A.Poveda,
A.M.Fernández,
J.Gómez,
and
J.M.González-Ros
(2006).
Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA.
|
| |
J Biol Chem,
281,
29905-29915.
|
|
|
|
|
|
|
M.Tadokoro,
S.Fukui,
T.Kitajima,
Y.Nagao,
S.Ishimaru,
H.Kitagawa,
K.Isobe,
and
K.Nakasuji
(2006).
Structures and phase transition of multi-layered water nanotube confined to nanochannels.
|
| |
Chem Commun (Camb),
(),
1274-1276.
|
|
|
|
|
|
|
N.Ge,
and
P.Linsdell
(2006).
Interactions between impermeant blocking ions in the cystic fibrosis transmembrane conductance regulator chloride channel pore: evidence for anion-induced conformational changes.
|
| |
J Membr Biol,
210,
31-42.
|
|
|
|
|
|
|
N.Shi,
S.Ye,
A.Alam,
L.Chen,
and
Y.Jiang
(2006).
Atomic structure of a Na+- and K+-conducting channel.
|
| |
Nature,
440,
570-574.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
O.Beckstein,
and
M.S.Sansom
(2006).
A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor.
|
| |
Phys Biol,
3,
147-159.
|
|
|
|
|
|
|
P.Escoubas
(2006).
Molecular diversification in spider venoms: a web of combinatorial peptide libraries.
|
| |
Mol Divers,
10,
545-554.
|
|
|
|
|
|
|
P.Huetz,
C.Boiteux,
M.Compoint,
C.Ramseyer,
and
C.Girardet
(2006).
Incidence of partial charges on ion selectivity in potassium channels.
|
| |
J Chem Phys,
124,
044703.
|
|
|
|
|
|
|
P.J.Stansfeld,
M.J.Sutcliffe,
and
J.S.Mitcheson
(2006).
Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.
|
| |
Expert Opin Drug Metab Toxicol,
2,
81-94.
|
|
|
|
|
|
|
P.Linsdell
(2006).
Mechanism of chloride permeation in the cystic fibrosis transmembrane conductance regulator chloride channel.
|
| |
Exp Physiol,
91,
123-129.
|
|
|
|
|
|
|
R.A.Piskorowski,
and
R.W.Aldrich
(2006).
Relationship between pore occupancy and gating in BK potassium channels.
|
| |
J Gen Physiol,
127,
557-576.
|
|
|
|
|
|
|
R.Blunck,
J.F.Cordero-Morales,
L.G.Cuello,
E.Perozo,
and
F.Bezanilla
(2006).
Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction.
|
| |
J Gen Physiol,
128,
569-581.
|
|
|
|
|
|
|
R.H.Meltzer,
E.Thompson,
K.V.Soman,
X.Z.Song,
J.O.Ebalunode,
T.G.Wensel,
J.M.Briggs,
and
S.E.Pedersen
(2006).
Electrostatic steering at acetylcholine binding sites.
|
| |
Biophys J,
91,
1302-1314.
|
|
|
|
|
|
|
R.L.Brown,
T.Strassmaier,
J.D.Brady,
and
J.W.Karpen
(2006).
The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness.
|
| |
Curr Pharm Des,
12,
3597-3613.
|
|
|
|
|
|
|
S.A.Spronk,
D.E.Elmore,
and
D.A.Dougherty
(2006).
Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance.
|
| |
Biophys J,
90,
3555-3569.
|
|
|
|
|
|
|
S.Furini,
F.Zerbetto,
and
S.Cavalcanti
(2006).
Application of the Poisson-Nernst-Planck theory with space-dependent diffusion coefficients to KcsA.
|
| |
Biophys J,
91,
3162-3169.
|
|
|
|
|
|
|
S.Lobet,
and
R.Dutzler
(2006).
Ion-binding properties of the ClC chloride selectivity filter.
|
| |
EMBO J,
25,
24-33.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.S.Deol,
C.Domene,
P.J.Bond,
and
M.S.Sansom
(2006).
Anionic phospholipid interactions with the potassium channel KcsA: simulation studies.
|
| |
Biophys J,
90,
822-830.
|
|
|
|
|
|
|
S.Ye,
Y.Li,
L.Chen,
and
Y.Jiang
(2006).
Crystal structures of a ligand-free MthK gating ring: insights into the ligand gating mechanism of K+ channels.
|
| |
Cell,
126,
1161-1173.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
T.P.Roosild,
S.Castronovo,
and
S.Choe
(2006).
Structure of anti-FLAG M2 Fab domain and its use in the stabilization of engineered membrane proteins.
|
| |
Acta Crystallogr Sect F Struct Biol Cryst Commun,
62,
835-839.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
W.N.Zagotta
(2006).
Membrane biology: permutations of permeability.
|
| |
Nature,
440,
427-429.
|
|
|
|
|
|
|
W.Qu,
A.J.Moorhouse,
M.Chandra,
K.D.Pierce,
T.M.Lewis,
and
P.H.Barry
(2006).
A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel.
|
| |
J Gen Physiol,
127,
375-389.
|
|
|
|
|
|
|
W.Xiong,
Y.Z.Farukhi,
Y.Tian,
D.Disilvestre,
R.A.Li,
and
G.F.Tomaselli
(2006).
A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation.
|
| |
J Physiol,
576,
739-754.
|
|
|
|
|
|
|
Y.Matoba,
T.Kumagai,
A.Yamamoto,
H.Yoshitsu,
and
M.Sugiyama
(2006).
Crystallographic evidence that the dinuclear copper center of tyrosinase is flexible during catalysis.
|
| |
J Biol Chem,
281,
8981-8990.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Wei,
and
D.Fu
(2006).
Binding and transport of metal ions at the dimer interface of the Escherichia coli metal transporter YiiP.
|
| |
J Biol Chem,
281,
23492-23502.
|
|
|
|
|
|
|
Z.A.Sands,
A.Grottesi,
and
M.S.Sansom
(2006).
The intrinsic flexibility of the Kv voltage sensor and its implications for channel gating.
|
| |
Biophys J,
90,
1598-1606.
|
|
|
|
|
|
|
A.C.Saladino,
Y.Xu,
and
P.Tang
(2005).
Homology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptor.
|
| |
Biophys J,
88,
1009-1017.
|
|
|
|
|
|
|
A.G.Lee
(2005).
How lipids and proteins interact in a membrane: a molecular approach.
|
| |
Mol Biosyst,
1,
203-212.
|
|
|
|
|
|
|
A.Giorgetti,
P.Carloni,
P.Mistrik,
and
V.Torre
(2005).
A homology model of the pore region of HCN channels.
|
| |
Biophys J,
89,
932-944.
|
|
|
|
|
|
|
A.Grottesi,
C.Domene,
S.Haider,
and
M.S.Sansom
(2005).
Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.
|
| |
IEEE Trans Nanobioscience,
4,
112-120.
|
|
|
|
|
|
|
A.Grottesi,
Z.A.Sands,
and
M.S.Sansom
(2005).
Potassium channels: complete and undistorted.
|
| |
Curr Biol,
15,
R771-R774.
|
|
|
|
|
|
|
A.M.Bittner
(2005).
Biomolecular rods and tubes in nanotechnology.
|
| |
Naturwissenschaften,
92,
51-64.
|
|
|
|
|
|
|
A.Rivetta,
C.Slayman,
and
T.Kuroda
(2005).
Quantitative modeling of chloride conductance in yeast TRK potassium transporters.
|
| |
Biophys J,
89,
2412-2426.
|
|
|
|
|
|
|
A.Roller,
G.Natura,
H.Bihler,
C.L.Slayman,
C.Eing,
and
A.Bertl
(2005).
In the yeast potassium channel, Tok1p, the external ring of aspartate residues modulates both gating and conductance.
|
| |
Pflugers Arch,
451,
362-370.
|
|
|
|
|
|
|
A.Staruschenko,
E.Adams,
R.E.Booth,
and
J.D.Stockand
(2005).
Epithelial Na+ channel subunit stoichiometry.
|
| |
Biophys J,
88,
3966-3975.
|
|
|
|
|
|
|
B.Chanda,
O.K.Asamoah,
R.Blunck,
B.Roux,
and
F.Bezanilla
(2005).
Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement.
|
| |
Nature,
436,
852-856.
|
|
|
|
|
|
|
B.Gilquin,
S.Braud,
M.A.Eriksson,
B.Roux,
T.D.Bailey,
B.T.Priest,
M.L.Garcia,
A.Ménez,
and
S.Gasparini
(2005).
A variable residue in the pore of Kv1 channels is critical for the high affinity of blockers from sea anemones and scorpions.
|
| |
J Biol Chem,
280,
27093-27102.
|
|
|
|
|
|
|
B.Roux
(2005).
Ion conduction and selectivity in K(+) channels.
|
| |
Annu Rev Biophys Biomol Struct,
34,
153-171.
|
|
|
|
|
|
|
C.Peter,
and
G.Hummer
(2005).
Ion transport through membrane-spanning nanopores studied by molecular dynamics simulations and continuum electrostatics calculations.
|
| |
Biophys J,
89,
2222-2234.
|
|
|
|
|
|
|
C.S.Gandhi,
and
E.Y.Isacoff
(2005).
Shedding light on membrane proteins.
|
| |
Trends Neurosci,
28,
472-479.
|
|
|
|
|
|
|
C.Wahl-Schott,
L.Baumann,
X.Zong,
and
M.Biel
(2005).
An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels.
|
| |
J Biol Chem,
280,
13694-13700.
|
|
|
|
|
|
|
D.L.Minor
(2005).
Bend to open?
|
| |
Structure,
13,
1094-1095.
|
|
|
|
|
|
|
D.del Camino,
M.Kanevsky,
and
G.Yellen
(2005).
Status of the intracellular gate in the activated-not-open state of shaker K+ channels.
|
| |
J Gen Physiol,
126,
419-428.
|
|
|
|
|
|
|
E.Gouaux,
and
R.Mackinnon
(2005).
Principles of selective ion transport in channels and pumps.
|
| |
Science,
310,
1461-1465.
|
|
|
|
|
|
|
E.Kutluay,
B.Roux,
and
L.Heginbotham
(2005).
Rapid intracellular TEA block of the KcsA potassium channel.
|
| |
Biophys J,
88,
1018-1029.
|
|
|
|
|
|
|
F.C.Chatelain,
N.Alagem,
Q.Xu,
R.Pancaroglu,
E.Reuveny,
and
D.L.Minor
(2005).
The pore helix dipole has a minor role in inward rectifier channel function.
|
| |
Neuron,
47,
833-843.
|
|
|
|
|
|
|
G.Uyeda,
A.Cámara-Artigas,
J.C.Williams,
and
J.P.Allen
(2005).
New tetragonal form of reaction centers from Rhodobacter sphaeroides and the involvement of a manganese ion at a crystal contact point.
|
| |
Acta Crystallogr Sect F Struct Biol Cryst Commun,
61,
733-736.
|
|
|
|
|
|
|
H.Ando,
M.Kuno,
H.Shimizu,
I.Muramatsu,
and
S.Oiki
(2005).
Coupled K+-water flux through the HERG potassium channel measured by an osmotic pulse method.
|
| |
J Gen Physiol,
126,
529-538.
|
|
|
|
|
|
|
H.X.Zhou
(2005).
How do biomolecular systems speed up and regulate rates?
|
| |
Phys Biol,
2,
R1-25.
|
|
|
|
|
|
|
I.S.Tolokh,
I.I.Tolokh,
H.C.Cho,
N.D'Avanzo,
P.H.Backx,
S.Goldman,
and
C.G.Gray
(2005).
Non-Michaelis-Menten kinetics model for conductance of low-conductance potassium ion channels.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys,
71,
021912.
|
|
|
|
|
|
|
J.Thompson,
and
T.Begenisich
(2005).
Two stable, conducting conformations of the selectivity filter in Shaker K+ channels.
|
| |
J Gen Physiol,
125,
619-629.
|
|
|
|
|
|
|
K.Oxenoid,
and
J.J.Chou
(2005).
The structure of phospholamban pentamer reveals a channel-like architecture in membranes.
|
| |
Proc Natl Acad Sci U S A,
102,
10870-10875.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.Gao,
X.Mi,
V.Paajanen,
K.Wang,
and
Z.Fan
(2005).
Activation-coupled inactivation in the bacterial potassium channel KcsA.
|
| |
Proc Natl Acad Sci U S A,
102,
17630-17635.
|
|
|
|
|
|
|
M.B.Ulmschneider,
M.S.Sansom,
and
A.Di Nola
(2005).
Properties of integral membrane protein structures: derivation of an implicit membrane potential.
|
| |
Proteins,
59,
252-265.
|
|
|
|
|
|
|
M.Compoint,
C.Boiteux,
P.Huetz,
C.Ramseyer,
and
C.Girardet
(2005).
Role of water molecules in the KcsA protein channel by molecular dynamics calculations.
|
| |
Phys Chem Chem Phys,
7,
4138-4145.
|
|
|
|
|
|
|
M.Compoint,
F.Picaud,
C.Ramseyer,
and
C.Girardet
(2005).
Targeted molecular dynamics of an open-state KcsA channel.
|
| |
J Chem Phys,
122,
134707.
|
|
|
|
|
|
|
M.F.Roberts
(2005).
Organic compatible solutes of halotolerant and halophilic microorganisms.
|
| |
Saline Systems,
1,
5.
|
|
|
|
|
|
|
M.J.Lenaeus,
M.Vamvouka,
P.J.Focia,
and
A.Gross
(2005).
Structural basis of TEA blockade in a model potassium channel.
|
| |
Nat Struct Mol Biol,
12,
454-459.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.L.Chapman,
and
A.M.VanDongen
(2005).
K channel subconductance levels result from heteromeric pore conformations.
|
| |
J Gen Physiol,
126,
87.
|
|
|
|
|
|
|
M.M.Kuo,
W.J.Haynes,
S.H.Loukin,
C.Kung,
and
Y.Saimi
(2005).
Prokaryotic K(+) channels: from crystal structures to diversity.
|
| |
FEMS Microbiol Rev,
29,
961-985.
|
|
|
|
|
|
|
M.N.Krishnan,
J.P.Bingham,
S.H.Lee,
P.Trombley,
and
E.Moczydlowski
(2005).
Functional role and affinity of inorganic cations in stabilizing the tetrameric structure of the KcsA K+ channel.
|
| |
J Gen Physiol,
126,
271-283.
|
|
|
|
|
|
|
N.Shin,
H.Soh,
S.Chang,
D.H.Kim,
and
C.S.Park
(2005).
Sodium permeability of a cloned small-conductance calcium-activated potassium channel.
|
| |
Biophys J,
89,
3111-3119.
|
|
|
|
|
|
|
N.Tholema,
M.Vor der Brüggen,
P.Mäser,
T.Nakamura,
J.I.Schroeder,
H.Kobayashi,
N.Uozumi,
and
E.P.Bakker
(2005).
All four putative selectivity filter glycine residues in KtrB are essential for high affinity and selective K+ uptake by the KtrAB system from Vibrio alginolyticus.
|
| |
J Biol Chem,
280,
41146-41154.
|
|
|
|
|
|
|
P.C.Jordan
(2005).
Fifty years of progress in ion channel research.
|
| |
IEEE Trans Nanobioscience,
4,
3-9.
|
|
|
|
|
|
|
P.C.Jordan
(2005).
Semimicroscopic modeling of permeation energetics in ion channels.
|
| |
IEEE Trans Nanobioscience,
4,
94.
|
|
|
|
|
|
|
P.Marius,
S.J.Alvis,
J.M.East,
and
A.G.Lee
(2005).
The interfacial lipid binding site on the potassium channel KcsA is specific for anionic phospholipids.
|
| |
Biophys J,
89,
4081-4089.
|
|
|
|
|
|
|
R.J.French,
and
G.W.Zamponi
(2005).
Voltage-gated sodium and calcium channels in nerve, muscle, and heart.
|
| |
IEEE Trans Nanobioscience,
4,
58-69.
|
|
|
|
|
|
|
S.B.Long,
E.B.Campbell,
and
R.Mackinnon
(2005).
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
|
| |
Science,
309,
897-903.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.Bernèche,
and
B.Roux
(2005).
A gate in the selectivity filter of potassium channels.
|
| |
Structure,
13,
591-600.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
S.C.Hebert,
G.Desir,
G.Giebisch,
and
W.Wang
(2005).
Molecular diversity and regulation of renal potassium channels.
|
| |
Physiol Rev,
85,
319-371.
|
|
|
|
|
|
|
S.Ding,
L.Ingleby,
C.A.Ahern,
and
R.Horn
(2005).
Investigating the putative glycine hinge in Shaker potassium channel.
|
| |
J Gen Physiol,
126,
213-226.
|
|
|
|
|
|
|
S.J.Korn,
and
J.G.Trapani
(2005).
Potassium channels.
|
| |
IEEE Trans Nanobioscience,
4,
21-33.
|
|
|
|
|
|
|
S.Sheng,
C.J.Perry,
O.B.Kashlan,
and
T.R.Kleyman
(2005).
Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.
|
| |
J Biol Chem,
280,
8513-8522.
|
|
|
|
|
|
|
T.I.Brelidze,
and
K.L.Magleby
(2005).
Probing the geometry of the inner vestibule of BK channels with sugars.
|
| |
J Gen Physiol,
126,
105-121.
|
|
|
|
|
|
|
V.Chevelkov,
K.Faelber,
A.Diehl,
U.Heinemann,
H.Oschkinat,
and
B.Reif
(2005).
Detection of dynamic water molecules in a microcrystalline sample of the SH3 domain of alpha-spectrin by MAS solid-state NMR.
|
| |
J Biomol NMR,
31,
295-310.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
X.Wang,
T.A.Ponoran,
R.L.Rasmusson,
D.S.Ragsdale,
and
B.Z.Peterson
(2005).
Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents.
|
| |
Biophys J,
89,
1731-1743.
|
|
|
|
|
|
|
Y.Wu,
X.Qian,
Y.He,
I.A.Moya,
and
Y.Luo
(2005).
Crystal structure of an ATPase-active form of Rad51 homolog from Methanococcus voltae. Insights into potassium dependence.
|
| |
J Biol Chem,
280,
722-728.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Accardi,
and
C.Miller
(2004).
Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels.
|
| |
Nature,
427,
803-807.
|
|
|
|
|
|
|
A.Boccaccio,
F.Conti,
B.M.Olivera,
and
H.Terlau
(2004).
Binding of kappa-conotoxin PVIIA to Shaker K+ channels reveals different K+ and Rb+ occupancies within the ion channel pore.
|
| |
J Gen Physiol,
124,
71-81.
|
|
|
|
|
|
|
A.Dahlmann,
M.Li,
Z.Gao,
D.McGarrigle,
H.Sackin,
and
L.G.Palmer
(2004).
Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling.
|
| |
J Gen Physiol,
123,
441-454.
|
|
|
|
|
|
|
A.I.Sobolevsky,
M.V.Yelshansky,
and
L.P.Wollmuth
(2004).
The outer pore of the glutamate receptor channel has 2-fold rotational symmetry.
|
| |
Neuron,
41,
367-378.
|
|
|
|
|
|
|
A.M.Slovic,
H.Kono,
J.D.Lear,
J.G.Saven,
and
W.F.DeGrado
(2004).
Computational design of water-soluble analogues of the potassium channel KcsA.
|
| |
Proc Natl Acad Sci U S A,
101,
1828-1833.
|
|
|
|
|
|
|
B.Roux,
and
K.Schulten
(2004).
Computational studies of membrane channels.
|
| |
Structure,
12,
1343-1351.
|
|
|
|
|
|
|
C.Domene,
A.Grottesi,
and
M.S.Sansom
(2004).
Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.
|
| |
Biophys J,
87,
256-267.
|
|
|
|
|
|
|
C.Kung,
and
P.Blount
(2004).
Channels in microbes: so many holes to fill.
|
| |
Mol Microbiol,
53,
373-380.
|
|
|
|
|
|
|
D.Bichet,
Y.F.Lin,
C.A.Ibarra,
C.S.Huang,
B.A.Yi,
Y.N.Jan,
and
L.Y.Jan
(2004).
Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity.
|
| |
Proc Natl Acad Sci U S A,
101,
4441-4446.
|
|
|
|
|
|
|
D.S.Murray,
M.A.Schumacher,
and
R.G.Brennan
(2004).
Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization.
|
| |
J Biol Chem,
279,
14365-14371.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
F.Gómez-Lagunas,
C.V.Batista,
T.Olamendi-Portugal,
M.E.Ramírez-Domínguez,
and
L.D.Possani
(2004).
Inhibition of the collapse of the Shaker K+ conductance by specific scorpion toxins.
|
| |
J Gen Physiol,
123,
265-279.
|
|
|
|
|
|
|
F.I.Valiyaveetil,
M.Sekedat,
R.Mackinnon,
and
T.W.Muir
(2004).
Glycine as a D-amino acid surrogate in the K(+)-selectivity filter.
|
| |
Proc Natl Acad Sci U S A,
101,
17045-17049.
|
|
|
|
|
|
|
H.Choi,
and
L.Heginbotham
(2004).
Functional influence of the pore helix glutamate in the KcsA K+ channel.
|
| |
Biophys J,
86,
2137-2144.
|
|
|
|
|
|
|
H.J.Woo,
A.R.Dinner,
and
B.Roux
(2004).
Grand canonical Monte Carlo simulations of water in protein environments.
|
| |
J Chem Phys,
121,
6392-6400.
|
|
|
|
|
|
|
H.Sackin,
L.G.Palmer,
and
M.Krambis
(2004).
Potassium-dependent slow inactivation of Kir1.1 (ROMK) channels.
|
| |
Biophys J,
86,
2145-2155.
|
|
|
|
|
|
|
I.H.Shrivastava,
S.R.Durell,
and
H.R.Guy
(2004).
A model of voltage gating developed using the KvAP channel crystal structure.
|
| |
Biophys J,
87,
2255-2270.
|
|
|
|
|
|
|
J.D.Faraldo-Gómez,
L.R.Forrest,
M.Baaden,
P.J.Bond,
C.Domene,
G.Patargias,
J.Cuthbertson,
and
M.S.Sansom
(2004).
Conformational sampling and dynamics of membrane proteins from 10-nanosecond computer simulations.
|
| |
Proteins,
57,
783-791.
|
|
|
|
|
|
|
J.Dzubiella,
R.J.Allen,
and
J.P.Hansen
(2004).
Electric field-controlled water permeation coupled to ion transport through a nanopore.
|
| |
J Chem Phys,
120,
5001-5004.
|
|
|
|
|
|
|
J.F.Consiglio,
and
S.J.Korn
(2004).
Influence of permeant ions on voltage sensor function in the Kv2.1 potassium channel.
|
| |
J Gen Physiol,
123,
387-400.
|
|
|
|
|
|
|
J.M.Gulbis,
and
D.A.Doyle
(2004).
Potassium channel structures: do they conform?
|
| |
Curr Opin Struct Biol,
14,
440-446.
|
|
|
|
|
|
|
J.Piasecki,
R.J.Allen,
and
J.P.Hansen
(2004).
Kinetic models of ion transport through a nanopore.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys,
70,
021105.
|
|
|
|
|
|
|
J.W.Karpen
(2004).
Ion channel structure and the promise of bacteria: cyclic nucleotide-gated channels in the queue.
|
| |
J Gen Physiol,
124,
199-201.
|
|
|
|
|
|
|
K.J.Swartz
(2004).
Towards a structural view of gating in potassium channels.
|
| |
Nat Rev Neurosci,
5,
905-916.
|
|
|
|
|
|
|
K.Yu,
W.Fu,
H.Liu,
X.Luo,
K.X.Chen,
J.Ding,
J.Shen,
and
H.Jiang
(2004).
Computational simulations of interactions of scorpion toxins with the voltage-gated potassium ion channel.
|
| |
Biophys J,
86,
3542-3555.
|
|
|
|
|
|
|
L.A.Kim,
J.Furst,
D.Gutierrez,
M.H.Butler,
S.Xu,
S.A.Goldstein,
and
N.Grigorieff
(2004).
Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution.
|
| |
Neuron,
41,
513-519.
|
|
|
|
|
|
|
L.G.Cuello,
D.M.Cortes,
and
E.Perozo
(2004).
Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer.
|
| |
Science,
306,
491-495.
|
|
|
|
|
|
|
M.A.Schumacher,
M.Crum,
and
M.C.Miller
(2004).
Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex.
|
| |
Structure,
12,
849-860.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.C.Trudeau,
and
W.N.Zagotta
(2004).
Dynamics of Ca2+-calmodulin-dependent inhibition of rod cyclic nucleotide-gated channels measured by patch-clamp fluorometry.
|
| |
J Gen Physiol,
124,
211-223.
|
|
|
|
|
|
|
M.Carrillo-Tripp,
H.Saint-Martin,
and
I.Ortega-Blake
(2004).
Minimalist molecular model for nanopore selectivity.
|
| |
Phys Rev Lett,
93,
168104.
|
|
|
|
|
|
|
M.Gimpelev,
L.R.Forrest,
D.Murray,
and
B.Honig
(2004).
Helical packing patterns in membrane and soluble proteins.
|
| |
Biophys J,
87,
4075-4086.
|
|
|
|
|
|
|
M.Huang,
B.C.Furie,
and
B.Furie
(2004).
Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody.
|
| |
J Biol Chem,
279,
14338-14346.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
M.L.Mayer,
and
N.Armstrong
(2004).
Structure and function of glutamate receptor ion channels.
|
| |
Annu Rev Physiol,
66,
161-181.
|
|
|
|
|
|
|
M.Nakasako
(2004).
Water-protein interactions from high-resolution protein crystallography.
|
| |
Philos Trans R Soc Lond B Biol Sci,
359,
1191.
|
|
|
|
|
|
|
M.T.Facciotti,
S.Rouhani-Manshadi,
and
R.M.Glaeser
(2004).
Energy transduction in transmembrane ion pumps.
|
| |
Trends Biochem Sci,
29,
445-451.
|
|
|
|
|
|
|
P.Andalib,
J.F.Consiglio,
J.G.Trapani,
and
S.J.Korn
(2004).
The external TEA binding site and C-type inactivation in voltage-gated potassium channels.
|
| |
Biophys J,
87,
3148-3161.
|
|
|
|
|
|
|
R.E.García-Ferreiro,
D.Kerschensteiner,
F.Major,
F.Monje,
W.Stühmer,
and
L.A.Pardo
(2004).
Mechanism of block of hEag1 K+ channels by imipramine and astemizole.
|
| |
J Gen Physiol,
124,
301-317.
|
|
|
|
|
|
|
R.J.Law,
and
M.S.Sansom
(2004).
Homology modelling and molecular dynamics simulations: comparative studies of human aquaporin-1.
|
| |
Eur Biophys J,
33,
477-489.
|
|
|
|
|
|
|
S.Adachi-Akahane
(2004).
[Molecular and pharmacological bases for the gating regulation of L-type voltage-dependent Ca2+ channels]
|
| |
Nippon Yakurigaku Zasshi,
123,
197-209.
|
|
|
|
|
|
|
S.B.Yang,
P.Proks,
F.M.Ashcroft,
and
M.Rupnik
(2004).
Inhibition of ATP-sensitive potassium channels by haloperidol.
|
| |
Br J Pharmacol,
143,
960-967.
|
|
|
|
|
|
|
S.M.Saparov,
and
P.Pohl
(2004).
Beyond the diffusion limit: Water flow through the empty bacterial potassium channel.
|
| |
Proc Natl Acad Sci U S A,
101,
4805-4809.
|
|
|
|
|
|
|
S.M.Webster,
D.Del Camino,
J.P.Dekker,
and
G.Yellen
(2004).
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.
|
| |
Nature,
428,
864-868.
|
|
|
|
|
|
|
S.R.Durell,
I.H.Shrivastava,
and
H.R.Guy
(2004).
Models of the structure and voltage-gating mechanism of the shaker K+ channel.
|
| |
Biophys J,
87,
2116-2130.
|
|
|
|
|
|
|
S.S.Deol,
P.J.Bond,
C.Domene,
and
M.S.Sansom
(2004).
Lipid-protein interactions of integral membrane proteins: a comparative simulation study.
|
| |
Biophys J,
87,
3737-3749.
|
|
|
|
|
|
|
S.Y.Noskov,
S.Bernèche,
and
B.Roux
(2004).
Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands.
|
| |
Nature,
431,
830-834.
|
|
|
|
|
|
|
S.Yohannan,
S.Faham,
D.Yang,
J.P.Whitelegge,
and
J.U.Bowie
(2004).
The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors.
|
| |
Proc Natl Acad Sci U S A,
101,
959-963.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.Haug,
D.Sigg,
S.Ciani,
L.Toro,
E.Stefani,
and
R.Olcese
(2004).
Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect.
|
| |
J Gen Physiol,
124,
173-184.
|
|
|
|
|
|
|
T.Haug,
R.Olcese,
L.Toro,
and
E.Stefani
(2004).
Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.
|
| |
J Gen Physiol,
124,
185-197.
|
|
|
|
|
|
|
T.I.Brelidze,
and
K.L.Magleby
(2004).
Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages.
|
| |
J Gen Physiol,
123,
305-319.
|
|
|
|
|
|
|
T.Voets,
A.Janssens,
G.Droogmans,
and
B.Nilius
(2004).
Outer pore architecture of a Ca2+-selective TRP channel.
|
| |
J Biol Chem,
279,
15223-15230.
|
|
|
|
|
|
|
T.W.Allen,
O.S.Andersen,
and
B.Roux
(2004).
On the importance of atomic fluctuations, protein flexibility, and solvent in ion permeation.
|
| |
J Gen Physiol,
124,
679-690.
|
|
|
|
|
|
|
T.W.Claydon,
S.Y.Makary,
K.M.Dibb,
and
M.R.Boyett
(2004).
K+ activation of kir3.1/kir3.4 and kv1.4 K+ channels is regulated by extracellular charges.
|
| |
Biophys J,
87,
2407-2418.
|
|
|
|
|
|
|
V.L.Dorman,
and
P.C.Jordan
(2004).
Ionic permeation free energy in gramicidin: a semimicroscopic perspective.
|
| |
Biophys J,
86,
3529-3541.
|
|
|
|
|
|
|
W.Kühlbrandt
(2004).
Biology, structure and mechanism of P-type ATPases.
|
| |
Nat Rev Mol Cell Biol,
5,
282-295.
|
|
|
|
|
|
|
W.Welch,
S.Rheault,
D.J.West,
and
A.J.Williams
(2004).
A model of the putative pore region of the cardiac ryanodine receptor channel.
|
| |
Biophys J,
87,
2335-2351.
|
|
|
|
|
|
|
Y.Dodier,
U.Banderali,
H.Klein,
O.Topalak,
O.Dafi,
M.Simoes,
G.Bernatchez,
R.Sauvé,
and
L.Parent
(2004).
Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis.
|
| |
J Biol Chem,
279,
6853-6862.
|
|
|
|
|
|
|
Y.Fujiwara,
and
Y.Kubo
(2004).
Density-dependent changes of the pore properties of the P2X2 receptor channel.
|
| |
J Physiol,
558,
31-43.
|
|
|
|
|
|
|
Z.Lu
(2004).
Mechanism of rectification in inward-rectifier K+ channels.
|
| |
Annu Rev Physiol,
66,
103-129.
|
|
|
|
|
|
|
Z.Qu,
R.Fischmeister,
and
C.Hartzell
(2004).
Mouse bestrophin-2 is a bona fide Cl(-) channel: identification of a residue important in anion binding and conduction.
|
| |
J Gen Physiol,
123,
327-340.
|
|
|
|
|
|
|
A.Giorgetti,
and
P.Carloni
(2003).
Molecular modeling of ion channels: structural predictions.
|
| |
Curr Opin Chem Biol,
7,
150-156.
|
|
|
|
|
|
|
A.J.Labro,
A.L.Raes,
I.Bellens,
N.Ottschytsch,
and
D.J.Snyders
(2003).
Gating of shaker-type channels requires the flexibility of S6 caused by prolines.
|
| |
J Biol Chem,
278,
50724-50731.
|
|
|
|
|
|
|
A.Kuo,
J.M.Gulbis,
J.F.Antcliff,
T.Rahman,
E.D.Lowe,
J.Zimmer,
J.Cuthbertson,
F.M.Ashcroft,
T.Ezaki,
and
D.A.Doyle
(2003).
Crystal structure of the potassium channel KirBac1.1 in the closed state.
|
| |
Science,
300,
1922-1926.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.S.Ghatpande,
R.Uma,
and
J.W.Karpen
(2003).
A multiply charged tetracaine derivative blocks cyclic nucleotide-gated channels at subnanomolar concentrations.
|
| |
Biochemistry,
42,
265-270.
|
|
|
|
|
|
|
B.D.Silverman
(2003).
Hydrophobicity of transmembrane proteins: spatially profiling the distribution.
|
| |
Protein Sci,
12,
586-599.
|
|
|
|
|
|
|
B.L.Kelly,
and
A.Gross
(2003).
Potassium channel gating observed with site-directed mass tagging.
|
| |
Nat Struct Biol,
10,
280-284.
|
|
|
|
|
|
|
C.Domene,
and
M.S.Sansom
(2003).
Potassium channel, ions, and water: simulation studies based on the high resolution X-ray structure of KcsA.
|
| |
Biophys J,
85,
2787-2800.
|
|
|
|
|
|
|
C.E.Capener,
P.Proks,
F.M.Ashcroft,
and
M.S.Sansom
(2003).
Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
|
| |
Biophys J,
84,
2345-2356.
|
|
|
|
|
|
|
C.Erxleben,
C.Gomez-Alegria,
T.Darden,
Y.Mori,
L.Birnbaumer,
and
D.L.Armstrong
(2003).
Modulation of cardiac Ca(V)1.2 channels by dihydropyridine and phosphatase inhibitor requires Ser-1142 in the domain III pore loop.
|
| |
Proc Natl Acad Sci U S A,
100,
2929-2934.
|
|
|
|
|
|
|
C.Tian,
P.F.Gao,
L.H.Pinto,
R.A.Lamb,
and
T.A.Cross
(2003).
Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers.
|
| |
Protein Sci,
12,
2597-2605.
|
|
|
|
|
|
|
D.Bichet,
F.A.Haass,
and
L.Y.Jan
(2003).
Merging functional studies with structures of inward-rectifier K(+) channels.
|
| |
Nat Rev Neurosci,
4,
957-967.
|
|
|
|
|
|
|
D.E.Clapham,
R.MacKinnon,
and
P.Agre
(2003).
Symmetry, selectivity, and the 2003 Nobel Prize.
|
| |
Cell,
115,
641-646.
|
|
|
|
|
|
|
D.Guo,
Y.Ramu,
A.M.Klem,
and
Z.Lu
(2003).
Mechanism of rectification in inward-rectifier K+ channels.
|
| |
J Gen Physiol,
121,
261-275.
|
|
|
|
|
|
|
D.Guo,
and
Z.Lu
(2003).
Interaction mechanisms between polyamines and IRK1 inward rectifier K+ channels.
|
| |
J Gen Physiol,
122,
485-500.
|
|
|
|
|
|
|
D.L.Prole,
P.A.Lima,
and
N.V.Marrion
(2003).
Mechanisms underlying modulation of neuronal KCNQ2/KCNQ3 potassium channels by extracellular protons.
|
| |
J Gen Physiol,
122,
775-793.
|
|
|
|
|
|
|
D.Sigg,
F.Bezanilla,
and
E.Stefani
(2003).
Fast gating in the Shaker K+ channel and the energy landscape of activation.
|
| |
Proc Natl Acad Sci U S A,
100,
7611-7615.
|
|
|
|
|
|
|
E.J.Neale,
D.J.Elliott,
M.Hunter,
and
A.Sivaprasadarao
(2003).
Evidence for intersubunit interactions between S4 and S5 transmembrane segments of the Shaker potassium channel.
|
| |
J Biol Chem,
278,
29079-29085.
|
|
|
|
|
|
|
F.Gomez-Lagunas,
A.Melishchuk,
and
C.M.Armstrong
(2003).
Block of Shaker potassium channels by external calcium ions.
|
| |
Proc Natl Acad Sci U S A,
100,
347-351.
|
|
|
|
|
|
|
G.E.Flynn,
and
W.N.Zagotta
(2003).
A cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore.
|
| |
J Gen Physiol,
121,
563-582.
|
|
|
|
|
|
|
H.Chen,
F.Sesti,
and
S.A.Goldstein
(2003).
Pore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunits.
|
| |
Biophys J,
84,
3679-3689.
|
|
|
|
|
|
|
H.Sackin,
A.Vasilyev,
L.G.Palmer,
and
M.Krambis
(2003).
Permeant cations and blockers modulate pH gating of ROMK channels.
|
| |
Biophys J,
84,
910-921.
|
|
|
|
|
|
|
H.Shimizu,
C.Toyoshima,
and
S.Oiki
(2003).
Interaction between tetraethylammonium and permeant cations at the inactivation gate of the HERG potassium channel.
|
| |
Jpn J Physiol,
53,
25-34.
|
|
|
|
|
|
|
I.I.Pottosin,
and
M.Martínez-Estévez
(2003).
Regulation of the fast vacuolar channel by cytosolic and vacuolar potassium.
|
| |
Biophys J,
84,
977-986.
|
|
|
|
|
|
|
J.A.Maurer,
and
D.A.Dougherty
(2003).
Generation and evaluation of a large mutational library from the Escherichia coli mechanosensitive channel of large conductance, MscL: implications for channel gating and evolutionary design.
|
| |
J Biol Chem,
278,
21076-21082.
|
|
|
|
|
|
|
J.B.Park,
H.J.Kim,
P.D.Ryu,
and
E.Moczydlowski
(2003).
Effect of phosphatidylserine on unitary conductance and Ba2+ block of the BK Ca2+-activated K+ channel: re-examination of the surface charge hypothesis.
|
| |
J Gen Physiol,
121,
375-397.
|
|
|
|
|
|
|
J.F.Consiglio,
P.Andalib,
and
S.J.Korn
(2003).
Influence of pore residues on permeation properties in the Kv2.1 potassium channel. Evidence for a selective functional interaction of K+ with the outer vestibule.
|
| |
J Gen Physiol,
121,
111-124.
|
|
|
|
|
|
|
J.Li,
L.Shi,
and
A.Karlin
(2003).
A photochemical approach to the lipid accessibility of engineered cysteinyl residues.
|
| |
Proc Natl Acad Sci U S A,
100,
886-891.
|
|
|
|
|
|
|
J.Thompson,
and
T.Begenisich
(2003).
Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels.
|
| |
J Physiol,
549,
107-120.
|
|
|
|
|
|
|
K.Hui,
D.McIntyre,
and
R.J.French
(2003).
Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel.
|
| |
J Gen Physiol,
122,
63-79.
|
|
|
|
|
|
|
K.M.Dibb,
T.Rose,
S.Y.Makary,
T.W.Claydon,
D.Enkvetchakul,
R.Leach,
C.G.Nichols,
and
M.R.Boyett
(2003).
Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel.
|
| |
J Biol Chem,
278,
49537-49548.
|
|
|
|
|
|
|
L.Q.Gu,
S.Cheley,
and
H.Bayley
(2003).
Electroosmotic enhancement of the binding of a neutral molecule to a transmembrane pore.
|
| |
Proc Natl Acad Sci U S A,
100,
15498-15503.
|
|
|
|
|
|
|
M.Holmgren
(2003).
Influence of permeant ions on gating in cyclic nucleotide-gated channels.
|
| |
J Gen Physiol,
121,
61-72.
|
|
|
|
|
|
|
M.M.Kuo,
Y.Saimi,
and
C.Kung
(2003).
Gain-of-function mutations indicate that Escherichia coli Kch forms a functional K+ conduit in vivo.
|
| |
EMBO J,
22,
4049-4058.
|
|
|
|
|
|
|
M.Shahidullah,
and
M.Covarrubias
(2003).
The link between ion permeation and inactivation gating of Kv4 potassium channels.
|
| |
Biophys J,
84,
928-941.
|
|
|
|
|
|
|
M.Sukhareva,
D.H.Hackos,
and
K.J.Swartz
(2003).
Constitutive activation of the Shaker Kv channel.
|
| |
J Gen Physiol,
122,
541-556.
|
|
|
|
|
|
|
N.Alagem,
S.Yesylevskyy,
and
E.Reuveny
(2003).
The pore helix is involved in stabilizing the open state of inwardly rectifying K+ channels.
|
| |
Biophys J,
85,
300-312.
|
|
|
|
|
|
|
N.B.Cronin,
A.O'Reilly,
H.Duclohier,
and
B.A.Wallace
(2003).
Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation.
|
| |
J Biol Chem,
278,
10675-10682.
|
|
|
|
|
|
|
P.Fidzinski,
A.Knoll,
R.Rosenthal,
A.Schrey,
A.Vescovi,
U.Koert,
M.Wiederholt,
and
O.Strauss
(2003).
Electrophysiological response of cultured trabecular meshwork cells to synthetic ion channels.
|
| |
Chem Biol,
10,
35-43.
|
|
|
|
|
|
|
P.H.Nelson
(2003).
Modeling the concentration-dependent permeation modes of the KcsA potassium ion channel.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys,
68,
061908.
|
|
|
|
|
|
|
P.Proks,
J.F.Antcliff,
and
F.M.Ashcroft
(2003).
The ligand-sensitive gate of a potassium channel lies close to the selectivity filter.
|
| |
EMBO Rep,
4,
70-75.
|
|
|
|
|
|
|
P.R.Selvin
(2003).
Lighting up single ion channels.
|
| |
Biophys J,
84,
1-2.
|
|
|
|
|
|
|
R.Dutzler,
E.B.Campbell,
and
R.MacKinnon
(2003).
Gating the selectivity filter in ClC chloride channels.
|
| |
Science,
300,
108-112.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.E.Middleton,
M.Sanchez,
A.R.Linde,
R.M.Bugianesi,
G.Dai,
J.P.Felix,
S.L.Koprak,
M.J.Staruch,
M.Bruguera,
R.Cox,
A.Ghosh,
J.Hwang,
S.Jones,
M.Kohler,
R.S.Slaughter,
O.B.McManus,
G.J.Kaczorowski,
and
M.L.Garcia
(2003).
Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.
|
| |
Biochemistry,
42,
13698-13707.
|
|
|
|
|
|
|
R.Schmitt
(2003).
Helix rotation model of the flagellar rotary motor.
|
| |
Biophys J,
85,
843-852.
|
|
|
|
|
|
|
S.Bernèche,
and
B.Roux
(2003).
A microscopic view of ion conduction through the K+ channel.
|
| |
Proc Natl Acad Sci U S A,
100,
8644-8648.
|
|
|
|
|
|
|
S.C.Burdette,
and
S.J.Lippard
(2003).
Meeting of the minds: metalloneurochemistry.
|
| |
Proc Natl Acad Sci U S A,
100,
3605-3610.
|
|
|
|
|
|
|
S.Garofoli,
and
P.C.Jordan
(2003).
Modeling permeation energetics in the KcsA potassium channel.
|
| |
Biophys J,
84,
2814-2830.
|
|
|
|
|
|
|
S.J.Alvis,
I.M.Williamson,
J.M.East,
and
A.G.Lee
(2003).
Interactions of anionic phospholipids and phosphatidylethanolamine with the potassium channel KcsA.
|
| |
Biophys J,
85,
3828-3838.
|
|
|
|
|
|
|
T.BaĆtuÄ,
and
S.Kuyucak
(2003).
Role of the dielectric constants of membrane proteins and channel water in ion permeation.
|
| |
Biophys J,
84,
2871-2882.
|
|
|
|
|
|
|
T.I.Brelidze,
X.Niu,
and
K.L.Magleby
(2003).
A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification.
|
| |
Proc Natl Acad Sci U S A,
100,
9017-9022.
|
|
|
|
|
|
|
T.W.Claydon,
S.Y.Makary,
K.M.Dibb,
and
M.R.Boyett
(2003).
The selectivity filter may act as the agonist-activated gate in the G protein-activated Kir3.1/Kir3.4 K+ channel.
|
| |
J Biol Chem,
278,
50654-50663.
|
|
|
|
|
|
|
W.A.Sather,
and
E.W.McCleskey
(2003).
Permeation and selectivity in calcium channels.
|
| |
Annu Rev Physiol,
65,
133-159.
|
|
|
|
|
|
|
W.J.Haynes,
K.Y.Ling,
Y.Saimi,
and
C.Kung
(2003).
PAK paradox: Paramecium appears to have more K(+)-channel genes than humans.
|
| |
Eukaryot Cell,
2,
737-745.
|
|
|
|
|
|
|
W.R.Silverman,
B.Roux,
and
D.M.Papazian
(2003).
Structural basis of two-stage voltage-dependent activation in K+ channels.
|
| |
Proc Natl Acad Sci U S A,
100,
2935-2940.
|
|
|
|
|
|
|
X.Gong,
and
P.Linsdell
(2003).
Mutation-induced blocker permeability and multiion block of the CFTR chloride channel pore.
|
| |
J Gen Physiol,
122,
673-687.
|
|
|
|
|
|
|
X.Gong,
and
P.Linsdell
(2003).
Molecular determinants and role of an anion binding site in the external mouth of the CFTR chloride channel pore.
|
| |
J Physiol,
549,
387-397.
|
|
|
|
|
|
|
Y.Jiang,
A.Lee,
J.Chen,
V.Ruta,
M.Cadene,
B.T.Chait,
and
R.MacKinnon
(2003).
X-ray structure of a voltage-dependent K+ channel.
|
| |
Nature,
423,
33-41.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
A.Bucchi,
M.Baruscotti,
and
D.DiFrancesco
(2002).
Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine.
|
| |
J Gen Physiol,
120,
1.
|
|
|
|
|
|
|
A.G.Lee
(2002).
A calcium pump made visible.
|
| |
Curr Opin Struct Biol,
12,
547-554.
|
|
|
|
|
|
|
A.S.Yu
(2002).
Elucidating the structural basis of membrane transport protein function: light at the end of the channel?
|
| |
Curr Opin Nephrol Hypertens,
11,
523-526.
|
|
|
|
|
|
|
B.Byrne,
and
S.Iwata
(2002).
Membrane protein complexes.
|
| |
Curr Opin Struct Biol,
12,
239-243.
|
|
|
|
|
|
|
B.Gilquin,
J.Racapé,
A.Wrisch,
V.Visan,
A.Lecoq,
S.Grissmer,
A.Ménez,
and
S.Gasparini
(2002).
Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers.
|
| |
J Biol Chem,
277,
37406-37413.
|
|
|
|
|
|
|
B.Roux
(2002).
Theoretical and computational models of ion channels.
|
| |
Curr Opin Struct Biol,
12,
182-189.
|
|
|
|
|
|
|
C.Hunte,
and
H.Michel
(2002).
Crystallisation of membrane proteins mediated by antibody fragments.
|
| |
Curr Opin Struct Biol,
12,
503-508.
|
|
|
|
|
|
|
C.M.Ghim,
and
J.M.Park
(2002).
Physical model for the gating mechanism of ionic channels.
|
| |
Phys Rev E Stat Nonlin Soft Matter Phys,
66,
051910.
|
|
|
|
|
|
|
C.M.Nimigean,
and
C.Miller
(2002).
Na+ block and permeation in a K+ channel of known structure.
|
| |
J Gen Physiol,
120,
323-335.
|
|
|
|
|
|
|
F.M.Mullins,
S.Z.Stepanovic,
R.R.Desai,
A.L.George,
and
J.R.Balser
(2002).
Extracellular sodium interacts with the HERG channel at an outer pore site.
|
| |
J Gen Physiol,
120,
517-537.
|
|
|
|
|
|
|
F.Mancia,
and
L.Shapiro
(2002).
Chloride channel function: partial charges and dipolar rods.
|
| |
Structure,
10,
283-284.
|
|
|
|
|
|
|
G.Li,
and
Q.Cui
(2002).
A coarse-grained normal mode approach for macromolecules: an efficient implementation and application to Ca(2+)-ATPase.
|
| |
Biophys J,
83,
2457-2474.
|
|
|
|
|
|
|
G.Yellen
(2002).
The voltage-gated potassium channels and their relatives.
|
| |
Nature,
419,
35-42.
|
|
|
|
|
|
|
H.P.Larsson
(2002).
The search is on for the voltage sensor-to-gate coupling.
|
| |
J Gen Physiol,
120,
475-481.
|
|
|
|
|
|
|
H.Soh,
and
C.S.Park
(2002).
Localization of divalent cation-binding site in the pore of a small conductance Ca(2+)-activated K(+) channel and its role in determining current-voltage relationship.
|
| |
Biophys J,
83,
2528-2538.
|
|
|
|
|
|
|
I.H.Shrivastava,
D.P.Tieleman,
P.C.Biggin,
and
M.S.Sansom
(2002).
K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study.
|
| |
Biophys J,
83,
633-645.
|
|
|
|
|
|
|
I.M.Williamson,
S.J.Alvis,
J.M.East,
and
A.G.Lee
(2002).
Interactions of phospholipids with the potassium channel KcsA.
|
| |
Biophys J,
83,
2026-2038.
|
|
|
|
|
|
|
I.Mus-Veteau
(2002).
Heterologous expression and purification systems for structural proteomics of Mammalian membrane proteins.
|
| |
Comp Funct Genomics,
3,
511-517.
|
|
|
|
|
|
|
J.Li,
Q.Xu,
D.M.Cortes,
E.Perozo,
A.Laskey,
and
A.Karlin
(2002).
Reactions of cysteines substituted in the amphipathic N-terminal tail of a bacterial potassium channel with hydrophilic and hydrophobic maleimides.
|
| |
Proc Natl Acad Sci U S A,
99,
11605-11610.
|
|
|
|
|
|
|
J.W.Karpen,
and
M.Ruiz
(2002).
Ion channels: does each subunit do something on its own?
|
| |
Trends Biochem Sci,
27,
402-409.
|
|
|
|
|
|
|
M.A.Eriksson,
and
B.Roux
(2002).
Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles.
|
| |
Biophys J,
83,
2595-2609.
|
|
|
|
|
|
|
M.Grunewald,
D.Menaker,
and
B.I.Kanner
(2002).
Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1.
|
| |
J Biol Chem,
277,
26074-26080.
|
|
|
|
|
|
|
M.Nishida,
and
R.MacKinnon
(2002).
Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution.
|
| |
Cell,
111,
957-965.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
M.S.Sansom,
and
C.E.Capener
(2002).
Ion channels: open at last.
|
| |
Curr Biol,
12,
R566-R568.
|
|
|
|
|
|
|
M.S.Sansom,
and
I.H.Shrivastava
(2002).
Ion channels: frozen motion.
|
| |
Curr Biol,
12,
R65-R67.
|
|
|
|
|
|
|
M.Schumacher,
and
J.P.Adelman
(2002).
Ion channels: an open and shut case.
|
| |
Nature,
417,
501-502.
|
|
|
|
|
|
|
O.Degen,
and
T.Eitinger
(2002).
Substrate specificity of nickel/cobalt permeases: insights from mutants altered in transmembrane domains I and II.
|
| |
J Bacteriol,
184,
3569-3577.
|
|
|
|
|
|
|
O.Yifrach,
and
R.MacKinnon
(2002).
Energetics of pore opening in a voltage-gated K(+) channel.
|
| |
Cell,
111,
231-239.
|
|
|
|
|
|
|
P.Andalib,
M.J.Wood,
and
S.J.Korn
(2002).
Control of outer vestibule dynamics and current magnitude in the Kv2.1 potassium channel.
|
| |
J Gen Physiol,
120,
739-755.
|
|
|
|
|
|
|
P.Mäser,
Y.Hosoo,
S.Goshima,
T.Horie,
B.Eckelman,
K.Yamada,
K.Yoshida,
E.P.Bakker,
A.Shinmyo,
S.Oiki,
J.I.Schroeder,
and
N.Uozumi
(2002).
Glycine residues in potassium channel-like selectivity filters determine potassium selectivity in four-loop-per-subunit HKT transporters from plants.
|
| |
Proc Natl Acad Sci U S A,
99,
6428-6433.
|
|
|
|
|
|
|
P.Roncaglia,
P.Mistrík,
and
V.Torre
(2002).
Pore topology of the hyperpolarization-activated cyclic nucleotide-gated channel from sea urchin sperm.
|
| |
Biophys J,
83,
1953-1964.
|
|
|
|
|
|
|
Q.H.Aziz,
C.J.Partridge,
T.S.Munsey,
and
A.Sivaprasadarao
(2002).
Depolarization induces intersubunit cross-linking in a S4 cysteine mutant of the Shaker potassium channel.
|
| |
J Biol Chem,
277,
42719-42725.
|
|
|
|
|
|
|
R.Allen,
S.Melchionna,
and
J.P.Hansen
(2002).
Intermittent permeation of cylindrical nanopores by water.
|
| |
Phys Rev Lett,
89,
175502.
|
|
|
|
|
|
|
R.Estévez,
and
T.J.Jentsch
(2002).
CLC chloride channels: correlating structure with function.
|
| |
Curr Opin Struct Biol,
12,
531-539.
|
|
|
|
|
|
|
R.H.Spencer,
and
D.C.Rees
(2002).
The alpha-helix and the organization and gating of channels.
|
| |
Annu Rev Biophys Biomol Struct,
31,
207-233.
|
|
|
|
|
|
|
R.MacKinnon
(2002).
Nothing automatic about ion-channel structures.
|
| |
Nature,
416,
261-262.
|
|
|
|
|
|
|
R.O.Blaustein
(2002).
Kinetics of tethering quaternary ammonium compounds to K(+) channels.
|
| |
J Gen Physiol,
120,
203-216.
|
|
|
|
|
|
|
S.Choe,
and
T.Roosild
(2002).
Regulation of the K channels by cytoplasmic domains.
|
| |
Biopolymers,
66,
294-299.
|
|
|
|
|
|
|
S.Ding,
and
R.Horn
(2002).
Tail end of the s6 segment: role in permeation in shaker potassium channels.
|
| |
J Gen Physiol,
120,
87-97.
|
|
|
|
|
|
|
S.H.Chung,
T.W.Allen,
and
S.Kuyucak
(2002).
Modeling diverse range of potassium channels with Brownian dynamics.
|
| |
Biophys J,
83,
263-277.
|
|
|
|
|
|
|
S.H.Loukin,
J.Lin,
U.Athar,
C.Palmer,
and
Y.Saimi
(2002).
The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel.
|
| |
Proc Natl Acad Sci U S A,
99,
1926-1930.
|
|
|
|
|
|
|
S.Rouhani,
M.T.Facciotti,
G.Woodcock,
V.Cheung,
C.Cunningham,
D.Nguyen,
B.Rad,
C.T.Lin,
C.S.Lunde,
and
R.M.Glaeser
(2002).
Crystallization of membrane proteins from media composed of connected-bilayer gels.
|
| |
Biopolymers,
66,
300-316.
|
|
|
|
|
|
|
T.P.Roosild,
S.Miller,
I.R.Booth,
and
S.Choe
(2002).
A mechanism of regulating transmembrane potassium flux through a ligand-mediated conformational switch.
|
| |
Cell,
109,
781-791.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.Voets,
J.Prenen,
J.Vriens,
H.Watanabe,
A.Janssens,
U.Wissenbach,
M.Bödding,
G.Droogmans,
and
B.Nilius
(2002).
Molecular determinants of permeation through the cation channel TRPV4.
|
| |
J Biol Chem,
277,
33704-33710.
|
|
|
|
|
|
|
V.Macri,
C.Proenza,
E.Agranovich,
D.Angoli,
and
E.A.Accili
(2002).
Separable gating mechanisms in a Mammalian pacemaker channel.
|
| |
J Biol Chem,
277,
35939-35946.
|
|
|
|
|
|
|
W.J.Haynes,
C.Kung,
Y.Saimi,
and
R.R.Preston
(2002).
An exchanger-like protein underlies the large Mg2+ current in Paramecium.
|
| |
Proc Natl Acad Sci U S A,
99,
15717-15722.
|
|
|
|
|
|
|
Y.Murata,
Y.Fujiwara,
and
Y.Kubo
(2002).
Identification of a site involved in the block by extracellular Mg(2+) and Ba(2+) as well as permeation of K(+) in the Kir2.1 K(+) channel.
|
| |
J Physiol,
544,
665-677.
|
|
|
|
|
|
|
Y.Shen,
Y.Kong,
and
J.Ma
(2002).
Intrinsic flexibility and gating mechanism of the potassium channel KcsA.
|
| |
Proc Natl Acad Sci U S A,
99,
1949-1953.
|
|
|
|
|
|
|
Z.Lu,
A.M.Klem,
and
Y.Ramu
(2002).
Coupling between voltage sensors and activation gate in voltage-gated K+ channels.
|
| |
J Gen Physiol,
120,
663-676.
|
|
|
|
|
|
|
Z.Siwy,
and
A.FuliĆski
(2002).
Origin of 1/f(alpha) noise in membrane channel currents.
|
| |
Phys Rev Lett,
89,
158101.
|
|
|
|
|
|
|
G.Yellen
(2001).
Keeping K+ completely comfortable.
|
| |
Nat Struct Biol,
8,
1011-1013.
|
|
|
|
|
|
|
N.Baderman,
J.Clough,
J.Milburn,
J.Owens,
and
B.Ramster
(2001).
News in brief.
|
| |
Drug Discov Today,
6,
1249-1254.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
 |
|
Links
