PDBsum entry 1j9c

Hydrolase/hydrolase inhibitor

PDB id: 1j9c

Contents

Protein chains

210 a.a. *

95 a.a. *

254 a.a. *

Ligands

GLC

FUL

0Z6

NAG

Metals

_CA

Waters ×127

* Residue conservation analysis

PDB id:

1j9c

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of tissue factor-factor viia complex

Structure:

Tissue factor. Chain: t. Synonym: tf, coagulation factor iii. Engineered: yes. Factor viia light chain. Chain: l. Engineered: yes. Factor viia heavy chain. Chain: h.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: bhk. Expression_system_cell_line: bhk

Biol. unit:

Tetramer (from PQS)

Resolution:

2.90Å R-factor: 0.221 R-free: 0.299

Authors:

M.Huang,W.Ruf,T.S.Edgington,I.A.Wilson

Key ref:

M.Huang et al. Ligand induced conformational transitions of tissue factor. Crystal structure of the tissue factor:factor viia complex.. To be published, .

Date:

24-May-01 Release date: 27-Jul-04

Protein chain

P13726  (TF_HUMAN) -  Tissue factor from Homo sapiens

Seq: 295 a.a.

Struc: 210 a.a.

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 95 a.a.

Protein chain

P08709  (FA7_HUMAN) -  Coagulation factor VII from Homo sapiens

Seq: 466 a.a.

Struc: 254 a.a.

Enzyme reactions

• Enzyme class: Chains L, H: E.C.3.4.21.21 - coagulation factor VIIa.
• Reaction: Hydrolyzes one Arg-|-Ile bond in factor X to form factor Xa.