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PDBsum entry 1if3
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protein Protein-protein interface(s) links
Virus/viral protein PDB id
1if3

 

 

 

 

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Contents
Protein chains
126 a.a.
Theoretical model
PDB id:
1if3
Name: Virus/viral protein
Title: Model for the structure of the HIV gp41 ectodomain
Structure: Envelope polyprotein gp160. Chain: a, b, c. Fragment: transmembrane glycoprotein (gp41), residues 540- 665
Source: Human immunodeficiency virus type 1 (lw12.3 isolate). HIV-1
Authors: M.Caffrey
Key ref: M.Caffrey (2001). Model for the structure of the HIV gp41 ectodomain: insight into the intermolecular interactions of the gp41 loop. Biochim Biophys Acta, 1536, 116-122. PubMed id: 11406346 DOI: 10.1016/S0925-4439(01)00042-4
Date:
12-Apr-01     Release date:   02-May-01    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q70626  (ENV_HV1LW) -  Envelope glycoprotein gp160 from Human immunodeficiency virus type 1 group M subtype B (isolate LW123)
Seq:
Struc: 		 
Seq:
Struc: 		856 a.a.
126 a.a.
Key:    PfamA domain  Secondary structure

 

 
DOI no: 10.1016/S0925-4439(01)00042-4 Biochim Biophys Acta 1536:116-122 (2001)
PubMed id: 11406346  
 
 
Model for the structure of the HIV gp41 ectodomain: insight into the intermolecular interactions of the gp41 loop.
M.Caffrey.
 
  ABSTRACT  
 
In human immunodeficiency virus (HIV) the viral envelope proteins gp41 and gp120 form a non-covalent complex, which is a potential target for AIDS therapies. In addition gp41 plays a possible role in HIV infection of B cells via the complement system. In an effort to better understand the molecular interactions of gp41, the structure of the HIV gp41 ectodomain has been modeled using the NMR restraints of the simian immunodeficiency virus (SIV) gp41 ectodomain (M. Caffrey, M. Cai, J. Kaufman, S.J. Stahl, P.T. Wingfield, A.M. Gronenborn, G.M. Clore, Solution structure of the 44 kDa ectodomain of SIV gp41, EMBO J. 17 (1998) 4572--4584). The resulting model presents the first structural information for the HIV gp41 loop, which has been implicated to play a direct role in binding to gp120 and C1q of the complement system.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
20230061 B.E.McGillick, T.E.Balius, S.Mukherjee, and R.C.Rizzo (2010).
Origins of resistance to the HIVgp41 viral entry inhibitor T20.
  Biochemistry, 49, 3575-3592.  
19340828 X.Z.Wu, S.Asai, and Y.Yamaguchi (2009).
Study of protein-protein binding reaction by whole-column fluorescence-imaged CIEF.
  Electrophoresis, 30, 1552-1557.  
18815131 J.Wang, J.Sen, L.Rong, and M.Caffrey (2008).
Role of the HIV gp120 Conserved Domain 1 in Processing and Viral Entry.
  J Biol Chem, 283, 32644-32649.  
17726011 A.Jacobs, O.Quraishi, X.Huang, N.Bousquet-Gagnon, G.Nault, N.Francella, W.G.Alvord, N.Pham, C.Soucy, M.Robitaille, D.Bridon, and R.Blumenthal (2007).
A covalent inhibitor targeting an intermediate conformation of the fusogenic subunit of the HIV-1 envelope complex.
  J Biol Chem, 282, 32406-32413.  
17525470 J.Sen, A.Jacobs, H.Jiang, L.Rong, and M.Caffrey (2007).
The disulfide loop of gp41 is critical to the furin recognition site of HIV gp160.
  Protein Sci, 16, 1236-1241.  
17372357 T.J.Oldfield (2007).
CAALIGN: a program for pairwise and multiple protein-structure alignment.
  Acta Crystallogr D Biol Crystallogr, 63, 514-525.  
16507566 S.Hakansson-McReynolds, S.Jiang, L.Rong, and M.Caffrey (2006).
Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state.
  J Biol Chem, 281, 11965-11971.
PDB code: 2fxp
15917239 A.Jacobs, J.Sen, L.Rong, and M.Caffrey (2005).
Alanine scanning mutants of the HIV gp41 loop.
  J Biol Chem, 280, 27284-27288.  
  15169554 R.W.Sanders, M.M.Dankers, E.Busser, M.Caffrey, J.P.Moore, and B.Berkhout (2004).
Evolution of the HIV-1 envelope glycoproteins with a disulfide bond between gp120 and gp41.
  Retrovirology, 1, 3.  
15066182 T.Krell, F.Greco, O.Engel, J.Dubayle, J.Dubayle, A.Kennel, B.Charloteaux, R.Brasseur, M.Chevalier, R.Sodoyer, and R.El Habib (2004).
HIV-1 gp41 and gp160 are hyperthermostable proteins in a mesophilic environment. Characterization of gp41 mutants.
  Eur J Biochem, 271, 1566-1579.  
12524303 L.Yang, M.E.Biswas, and P.Chen (2003).
Study of binding between protein A and immunoglobulin G using a surface tension probe.
  Biophys J, 84, 509-522.  
12354117 L.Guilhaudis, A.Jacobs, and M.Caffrey (2002).
Solution structure of the HIV gp120 C5 domain.
  Eur J Biochem, 269, 4860-4867.
PDB code: 1meq
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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