PDBsum entry 1i2k

Lyase

PDB id: 1i2k

Contents

Protein chain

269 a.a. *

Ligands

PLP

Waters ×212

* Residue conservation analysis

PDB id:

1i2k

Name:

Lyase

Title:

Aminodeoxychorismate lyase from escherichia coli

Structure:

4-amino-4-deoxychorismate lyase. Chain: a. Engineered: yes

Source:

Escherichia coli. Organism_taxid: 562. Gene: pabc. Expressed in: escherichia coli. Expression_system_taxid: 562

Biol. unit:

Dimer (from PDB file)

Resolution:

1.79Å R-factor: 0.163 R-free: 0.248

Authors:

P.Y.Jensen,J.F.Parsons,K.E.Fisher,A.S.Pachikara,M.Tordova,A.J.Howard, E.Eisenstein,J.E.Ladner

Key ref:

P.Y.Jensen et al. Structure and mechanism of escherichia coli aminodeoxychorismate lyase. To be published, .

Date:

09-Feb-01 Release date: 02-Sep-03

Protein chain

P28305  (PABC_ECOLI) -  Aminodeoxychorismate lyase from Escherichia coli (strain K12)

Seq: 269 a.a.

Struc: 269 a.a.

Enzyme reactions

• Enzyme class: E.C.4.1.3.38 - aminodeoxychorismate lyase.
• Pathway: Folate Biosynthesis (late stages)
• Reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + pyruvate + H⁺
• Cofactor: Pyridoxal 5'-phosphate

Pyridoxal 5'-phosphate (Bound ligand (Het Group name = PLP) matches with 93.75% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site