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PDBsum entry 1hsd
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protein links
Oxidoreductase PDB id
1hsd
Contents
Protein chains
255 a.a.*
* C-alpha coords only
Superseded by: 2hsd
PDB id:
1hsd
Name: Oxidoreductase
Structure: 3alpha,20beta- Hydroxysteroid dehydrogenase (holo form)
Source: (Streptomyces hydrogenans)
Authors: D.Ghosh,W.L.Duax
Key ref: D.Ghosh et al. (1991). Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family. Proc Natl Acad Sci U S A, 88, 10064-10068. PubMed id: 1946424 DOI: 10.1073/pnas.88.22.10064
Date:
15-Aug-91     Release date:   15-Apr-92    
 Headers
 References

Protein chains
No UniProt id for this chain
Struc: 255 a.a.
Key:    Secondary structure

 

 
    Key reference    
 
 
DOI no: 10.1073/pnas.88.22.10064 Proc Natl Acad Sci U S A 88:10064-10068 (1991)
PubMed id: 1946424  
 
 
Three-dimensional structure of holo 3 alpha,20 beta-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family.
D.Ghosh, C.M.Weeks, P.Grochulski, W.L.Duax, M.Erman, R.L.Rimsay, J.C.Orr.
 
  ABSTRACT  
 
The x-ray structure of a short-chain dehydrogenase, the bacterial holo 3 alpha,20 beta-hydroxysteroid dehydrogenase (EC 1.1.1.53), is described at 2.6 A resolution. This enzyme is active as a tetramer and crystallizes with four identical subunits in the asymmetric unit. It has the alpha/beta fold characteristic of the dinucleotide binding region. The fold of the rest of the subunit, the quaternary structure, and the nature of the cofactor-enzyme interactions are, however, significantly different from those observed in the long-chain dehydrogenases. The architecture of the postulated active site is consistent with the observed stereospecificity of the enzyme and the fact that the tetramer is the active form. There is only one cofactor and one substrate-binding site per subunit; the specificity for both 3 alpha- and 20 beta-ends of the steroid results from the binding of the steroid in two orientations near the same cofactor at the same catalytic site.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
19122202 K.Nakashima, K.Ito, Y.Nakajima, R.Yamazawa, S.Miyakawa, and T.Yoshimoto (2009).
Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor.
  J Biochem, 145, 467-479.
PDB codes: 2ztl 2ztm 2ztu 2ztv
19177572 Q.Zhang, H.Peng, F.Gao, Y.Liu, H.Cheng, J.Thompson, and G.F.Gao (2009).
Structural insight into the catalytic mechanism of gluconate 5-dehydrogenase from Streptococcus suis: Crystal structures of the substrate-free and quaternary complex enzymes.
  Protein Sci, 18, 294-303.
PDB codes: 3cxr 3cxt 3o03
18723681 F.Buhr, M.El Bakkouri, O.Valdez, S.Pollmann, N.Lebedev, S.Reinbothe, and C.Reinbothe (2008).
Photoprotective role of NADPH:protochlorophyllide oxidoreductase A.
  Proc Natl Acad Sci U S A, 105, 12629-12634.  
19011750 K.L.Kavanagh, H.Jörnvall, B.Persson, and U.Oppermann (2008).
Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes.
  Cell Mol Life Sci, 65, 3895-3906.  
18453685 M.M.Hoque, S.Shimizu, M.T.Hossain, T.Yamamoto, S.Imamura, K.Suzuki, M.Tsunoda, H.Amano, T.Sekiguchi, and A.Takénaka (2008).
The structures of Alcaligenes faecalis D-3-hydroxybutyrate dehydrogenase before and after NAD+ and acetate binding suggest a dynamical reaction mechanism as a member of the SDR family.
  Acta Crystallogr D Biol Crystallogr, 64, 496-505.
PDB codes: 2yz7 2zea 3vdq
18566346 R.Zhang, G.Zhu, W.Zhang, S.Cao, X.Ou, X.Li, M.Bartlam, Y.Xu, X.C.Zhang, and Z.Rao (2008).
Crystal structure of a carbonyl reductase from Candida parapsilosis with anti-Prelog stereospecificity.
  Protein Sci, 17, 1412-1423.
PDB code: 3ctm
17958702 K.S.Paithankar, C.Feller, E.B.Kuettner, A.Keim, M.Grunow, and N.Sträter (2007).
Cosubstrate-induced dynamics of D-3-hydroxybutyrate dehydrogenase from Pseudomonas putida.
  FEBS J, 274, 5767-5779.
PDB codes: 2q2q 2q2v 2q2w
16802208 B.C.Chu, and H.Lee (2006).
Investigation of the role of a conserved glycine motif in the Saccharomyces cerevisiae xylose reductase.
  Curr Microbiol, 53, 118-123.  
15906319 O.El-Kabbani, V.Carbone, C.Darmanin, S.Ishikura, and A.Hara (2005).
Structure of the tetrameric form of human L-Xylulose reductase: probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis.
  Proteins, 60, 424-432.
PDB code: 1wnt
16467263 W.L.Duax, J.Thomas, V.Pletnev, A.Addlagatta, R.Huether, L.Habegger, and C.M.Weeks (2005).
Determining structure and function of steroid dehydrogenase enzymes by sequence analysis, homology modeling, and rational mutational analysis.
  Ann N Y Acad Sci, 1061, 135-148.  
15103634 O.El-Kabbani, S.Ishikura, C.Darmanin, V.Carbone, R.P.Chung, N.Usami, and A.Hara (2004).
Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis.
  Proteins, 55, 724-732.
PDB code: 1pr9
14743862 B.Schoefs, and F.Franck (2003).
Protochlorophyllide reduction: mechanisms and evolutions.
  Photochem Photobiol, 78, 543-557.  
12951657 W.Moll, C.Lanwert, A.Stratmann, J.Strelau, and G.Jeserich (2003).
Molecular cloning, tissue expression, and partial characterization of the major fish CNS myelin protein 36k.
  Glia, 44, 57-66.  
11319027 C.W.Bachem, B.Horvath, L.Trindade, M.Claassens, E.Davelaar, W.Jordi, and R.G.Visser (2001).
A potato tuber-expressed mRNA with homology to steroid dehydrogenases affects gibberellin levels and plant development.
  Plant J, 25, 595-604.  
11306082 D.Ghosh, and P.Vihko (2001).
Molecular mechanisms of estrogen recognition and 17-keto reduction by human 17beta-hydroxysteroid dehydrogenase 1.
  Chem Biol Interact, 130, 637-650.  
11306088 E.Maser, G.Xiong, C.Grimm, R.Ficner, and K.Reuter (2001).
3alpha-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: biological significance, three-dimensional structure and gene regulation.
  Chem Biol Interact, 130, 707-722.  
11489858 J.E.van Hylckama Vlieg, L.Tang, J.H.Lutje Spelberg, T.Smilda, G.J.Poelarends, T.Bosma, A.E.van Merode, M.W.Fraaije, and D.B.Janssen (2001).
Halohydrin dehalogenases are structurally and mechanistically related to short-chain dehydrogenases/reductases.
  J Bacteriol, 183, 5058-5066.  
11358525 J.van der Oost, W.G.Voorhorst, S.W.Kengen, A.C.Geerling, V.Wittenhorst, Y.Gueguen, and W.M.de Vos (2001).
Genetic and biochemical characterization of a short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Eur J Biochem, 268, 3062-3068.  
11375507 M.Otagiri, G.Kurisu, S.Swaminathan, S.Ui, S.Yoneda, M.Ohkuma, T.Kudo, and M.Kusunoki (2001).
Crystallization and preliminary X-ray studies of meso-2,3-butanediol dehydrogenase from Klebsiella pneumoniae IAM1063.
  Acta Crystallogr D Biol Crystallogr, 57, 857-859.  
11287671 T.E.Hanson, and F.R.Tabita (2001).
A ribulose-1,5-bisphosphate carboxylase/oxygenase (RubisCO)-like protein from Chlorobium tepidum that is involved with sulfur metabolism and the response to oxidative stress.
  Proc Natl Acad Sci U S A, 98, 4397-4402.  
11559359 X.Y.He, G.Merz, Y.Z.Yang, P.Mehta, H.Schulz, and S.Y.Yang (2001).
Characterization and localization of human type10 17beta-hydroxysteroid dehydrogenase.
  Eur J Biochem, 268, 4899-4907.  
10828945 A.Schmidt, H.Wu, R.E.MacKenzie, V.J.Chen, J.R.Bewly, J.E.Ray, J.E.Toth, and M.Cygler (2000).
Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase.
  Biochemistry, 39, 6325-6335.
PDB codes: 1dia 1dib 1dig
11009606 C.Loeb-Hennard, and J.O.McIntyre (2000).
(R)-3-hydroxybutyrate dehydrogenase: selective phosphatidylcholine binding by the C-terminal domain.
  Biochemistry, 39, 11928-11938.  
10933785 D.Chelius, C.Loeb-Hennard, S.Fleischer, J.O.McIntyre, A.R.Marks, S.De, S.Hahn, M.M.Jehl, J.Moeller, R.Philipp, J.G.Wise, and W.E.Trommer (2000).
Phosphatidylcholine activation of human heart (R)-3-hydroxybutyrate dehydrogenase mutants lacking active center sulfhydryls: site-directed mutagenesis of a new recombinant fusion protein.
  Biochemistry, 39, 9687-9697.  
10848978 J.Benach, S.Atrian, J.Fibla, R.Gonzàlez-Duarte, and R.Ladenstein (2000).
Structure-function relationships in Drosophila melanogaster alcohol dehydrogenase allozymes ADH(S), ADH(F) and ADH(UF), and distantly related forms.
  Eur J Biochem, 267, 3613-3622.  
10666611 J.Valjakka, A.Hemminki, T.Teerinen, K.Takkinen, and J.Rouvinen (2000).
X-ray studies of recombinant anti-testosterone Fab fragments: the use of PEG 3350 in crystallization.
  Acta Crystallogr D Biol Crystallogr, 56, 218-221.  
11053846 K.Yamamoto, M.Kusunoki, I.Urabe, S.Tabata, and S.Osaki (2000).
Crystallization and preliminary X-ray analysis of glucose dehydrogenase from Bacillus megaterium IWG3.
  Acta Crystallogr D Biol Crystallogr, 56, 1443-1445.  
10091578 J.N.Tinguely, and B.Wermuth (1999).
Identification of the reactive cysteine residue (Cys227) in human carbonyl reductase.
  Eur J Biochem, 260, 9.  
10547700 L.J.Shimkets (1999).
Intercellular signaling during fruiting-body development of Myxococcus xanthus.
  Annu Rev Microbiol, 53, 525-549.  
  9922248 P.Aneja, and T.C.Charles (1999).
Poly-3-hydroxybutyrate degradation in Rhizobium (Sinorhizobium) meliloti: isolation and characterization of a gene encoding 3-hydroxybutyrate dehydrogenase.
  J Bacteriol, 181, 849-857.  
9708982 J.B.Thoden, and H.M.Holden (1998).
Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli.
  Biochemistry, 37, 11469-11477.
PDB codes: 1a9y 1a9z
9585418 L.Torroja, D.Ortuño-Sahagún, A.Ferrús, B.Hämmerle, and J.A.Barbas (1998).
scully, an essential gene of Drosophila, is homologous to mammalian mitochondrial type II L-3-hydroxyacyl-CoA dehydrogenase/amyloid-beta peptide-binding protein.
  J Cell Biol, 141, 1009-1017.  
9586999 M.A.Turner, C.S.Yuan, R.T.Borchardt, M.S.Hershfield, G.D.Smith, and P.L.Howell (1998).
Structure determination of selenomethionyl S-adenosylhomocysteine hydrolase using data at a single wavelength.
  Nat Struct Biol, 5, 369-376.
PDB code: 1a7a
9862812 W.S.Somers, M.L.Stahl, and F.X.Sullivan (1998).
GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site.
  Structure, 6, 1601-1612.
PDB codes: 1bsv 1fxs 1gfs
  9006050 F.Junker, R.Kiewitz, and A.M.Cook (1997).
Characterization of the p-toluenesulfonate operon tsaMBCD and tsaR in Comamonas testosteroni T-2.
  J Bacteriol, 179, 919-927.  
9174344 J.B.Thoden, A.D.Hegeman, G.Wesenberg, M.C.Chapeau, P.A.Frey, and H.M.Holden (1997).
Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli.
  Biochemistry, 36, 6294-6304.
PDB codes: 1uda 1udb 1udc
9271499 J.B.Thoden, A.M.Gulick, and H.M.Holden (1997).
Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli.
  Biochemistry, 36, 10685-10695.
PDB codes: 1kvq 1kvr 1kvs 1kvt
9128724 M.I.Barrasa, J.A.Tercero, and A.Jimenez (1997).
The aminonucleoside antibiotic A201A is inactivated by a phosphotransferase activity from Streptomyces capreolus NRRL 3817, the producing organism. Isolation and molecular characterization of the relevant encoding gene and its DNA flanking regions.
  Eur J Biochem, 245, 54-63.  
8979285 P.C.White, T.Mune, F.M.Rogerson, K.M.Kayes, and A.K.Agarwal (1997).
11 beta-Hydroxysteroid dehydrogenase and its role in the syndrome of apparent mineralocorticoid excess.
  Pediatr Res, 41, 25-29.  
8993315 U.C.Oppermann, C.Filling, K.D.Berndt, B.Persson, J.Benach, R.Ladenstein, and H.Jörnvall (1997).
Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions.
  Biochemistry, 36, 34-40.  
9271498 Y.Liu, J.B.Thoden, J.Kim, E.Berger, A.M.Gulick, F.J.Ruzicka, H.M.Holden, and P.A.Frey (1997).
Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli.
  Biochemistry, 36, 10675-10684.
PDB code: 1kvu
9095201 Z.J.Liu, Y.J.Sun, J.Rose, Y.J.Chung, C.D.Hsiao, W.R.Chang, I.Kuo, J.Perozich, R.Lindahl, J.Hempel, and B.C.Wang (1997).
The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold.
  Nat Struct Biol, 4, 317-326.
PDB code: 1ad3
8939741 A.Andersson, D.Jordan, G.Schneider, and Y.Lindqvist (1996).
Crystal structure of the ternary complex of 1,3,8-trihydroxynaphthalene reductase from Magnaporthe grisea with NADPH and an active-site inhibitor.
  Structure, 4, 1161-1170.
PDB code: 1ybv
8679568 D.Green, A.R.Marks, S.Fleischer, and J.O.McIntyre (1996).
Wild type and mutant human heart (R)-3-hydroxybutyrate dehydrogenase expressed in insect cells.
  Biochemistry, 35, 8158-8165.  
  8931134 J.B.Thoden, P.A.Frey, and H.M.Holden (1996).
High-resolution X-ray structure of UDP-galactose 4-epimerase complexed with UDP-phenol.
  Protein Sci, 5, 2149-2161.
PDB code: 2udp
8617258 J.Benach, S.Knapp, U.C.Oppermann, O.Hägglund, H.Jörnvall, and R.Ladenstein (1996).
Crystallization and crystal packing of recombinant 3 (or 17) beta-hydroxysteroid dehydrogenase from Comamonas testosteroni ATTC 11996.
  Eur J Biochem, 236, 144-148.  
  8576071 K.Lee, and L.J.Shimkets (1996).
Suppression of a signaling defect during Myxococcus xanthus development.
  J Bacteriol, 178, 977-984.  
8805511 N.Tanaka, T.Nonaka, M.Nakanishi, Y.Deyashiki, A.Hara, and Y.Mitsui (1996).
Crystal structure of the ternary complex of mouse lung carbonyl reductase at 1.8 A resolution: the structural origin of coenzyme specificity in the short-chain dehydrogenase/reductase family.
  Structure, 4, 33-45.
PDB code: 1cyd
8672472 N.Tanaka, T.Nonaka, T.Tanabe, T.Yoshimoto, D.Tsuru, and Y.Mitsui (1996).
Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli.
  Biochemistry, 35, 7715-7730.
PDB codes: 1ahh 1ahi 1fmc
8612620 P.Nokelainen, T.Puranen, H.Peltoketo, M.Orava, P.Vihko, and R.Vihko (1996).
Molecular cloning of mouse 17 beta-hydroxysteroid dehydrogenase type 1 and characterization of enzyme activity.
  Eur J Biochem, 236, 482-490.  
8805577 R.Breton, D.Housset, C.Mazza, and J.C.Fontecilla-Camps (1996).
The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
  Structure, 4, 905-915.
PDB codes: 1fds 1fdt
8749365 A.M.Lesk (1995).
NAD-binding domains of dehydrogenases.
  Curr Opin Struct Biol, 5, 775-783.  
7625731 D.Ghosh, Z.Wawrzak, V.Pletnev, M.Erman, W.L.Duax, W.Pangborn, D.W.Zhu, F.Labrie, and S.X.Lin (1995).
Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function.
  Ann N Y Acad Sci, 761, 341-343.  
7766153 D.H.Mallonee, M.A.Lijewski, and P.B.Hylemon (1995).
Expression in Escherichia coli and characterization of a bile acid-inducible 3 alpha-hydroxysteroid dehydrogenase from Eubacterium sp. strain VPI 12708.
  Curr Microbiol, 30, 259-263.  
7556196 F.Gabrielli, G.Donadel, G.Bensi, A.Heguy, and M.Melli (1995).
A nuclear protein, synthesized in growth-arrested human hepatoblastoma cells, is a novel member of the short-chain alcohol dehydrogenase family.
  Eur J Biochem, 232, 473-477.  
7846042 H.M.Wilks, and M.P.Timko (1995).
A light-dependent complementation system for analysis of NADPH:protochlorophyllide oxidoreductase: identification and mutagenesis of two conserved residues that are essential for enzyme activity.
  Proc Natl Acad Sci U S A, 92, 724-728.  
7483848 J.Hallborn, M.Walfridsson, M.Penttilä, S.Keränen, and B.Hahn-Hägerdal (1995).
A short-chain dehydrogenase gene from Pichia stipitis having D-arabinitol dehydrogenase activity.
  Yeast, 11, 839-847.  
  8652148 M.Poutanen, V.Isomaa, H.Peltoketo, and R.Vihko (1995).
Regulation of oestrogen action: role of 17 beta-hydroxysteroid dehydrogenases.
  Ann Med, 27, 675-682.  
7670488 T.Mune, F.M.Rogerson, H.Nikkilä, A.K.Agarwal, and P.C.White (1995).
Human hypertension caused by mutations in the kidney isozyme of 11 beta-hydroxysteroid dehydrogenase.
  Nat Genet, 10, 394-399.  
7851387 U.C.Oppermann, K.J.Netter, and E.Maser (1995).
Cloning and primary structure of murine 11 beta-hydroxysteroid dehydrogenase/microsomal carbonyl reductase.
  Eur J Biochem, 227, 202-208.  
8112349 A.Vidal-Cros, F.Viviani, G.Labesse, M.Boccara, and M.Gaudry (1994).
Polyhydroxynaphthalene reductase involved in melanin biosynthesis in Magnaporthe grisea. Purification, cDNA cloning and sequencing.
  Eur J Biochem, 219, 985-992.  
7866748 D.Ghosh, M.Erman, Z.Wawrzak, W.L.Duax, and W.Pangborn (1994).
Mechanism of inhibition of 3 alpha, 20 beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor.
  Structure, 2, 973-980.
PDB code: 1hdc
7922040 D.Ghosh, Z.Wawrzak, C.M.Weeks, W.L.Duax, and M.Erman (1994).
The refined three-dimensional structure of 3 alpha,20 beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases.
  Structure, 2, 629-640.
PDB code: 2hsd
  7920253 J.Hempel, J.Perozich, H.Romovacek, A.Hinich, I.Kuo, and D.S.Feingold (1994).
UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases.
  Protein Sci, 3, 1074-1080.  
  8050999 J.P.Coleman, L.L.Hudson, and M.J.Adams (1994).
Characterization and regulation of the NADP-linked 7 alpha-hydroxysteroid dehydrogenase gene from Clostridium sordellii.
  J Bacteriol, 176, 4865-4874.  
8202530 K.I.Varughese, N.H.Xuong, P.M.Kiefer, D.A.Matthews, and J.M.Whiteley (1994).
Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases.
  Proc Natl Acad Sci U S A, 91, 5582-5586.  
7881907 P.Rowland, A.K.Basak, S.Gover, H.R.Levy, and M.J.Adams (1994).
The three-dimensional structure of glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides refined at 2.0 A resolution.
  Structure, 2, 1073-1087.
PDB code: 1dpg
8146147 S.S.Hoog, J.E.Pawlowski, P.M.Alzari, T.M.Penning, and M.Lewis (1994).
Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily.
  Proc Natl Acad Sci U S A, 91, 2517-2521.
PDB code: 1ral
8281978 J.R.Seckl (1993).
11 beta-hydroxysteroid dehydrogenase isoforms and their implications for blood pressure regulation.
  Eur J Clin Invest, 23, 589-601.  
8415746 K.Nakajima, T.Hashimoto, and Y.Yamada (1993).
Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor.
  Proc Natl Acad Sci U S A, 90, 9591-9595.  
8421682 M.Krook, D.Ghosh, R.Strömberg, M.Carlquist, and H.Jörnvall (1993).
Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase.
  Proc Natl Acad Sci U S A, 90, 502-506.  
  1396560 B.Papadopoulou, G.Roy, and M.Ouellette (1992).
A novel antifolate resistance gene on the amplified H circle of Leishmania.
  EMBO J, 11, 3601-3608.  
1396701 M.Krook, V.Prozorovski, S.Atrian, R.Gonzàlez-Duarte, and H.Jörnvall (1992).
Short-chain dehydrogenases. Proteolysis and chemical modification of prokaryotic 3 alpha/20 beta-hydroxysteroid, insect alcohol and human 15-hydroxyprostaglandin dehydrogenases.
  Eur J Biochem, 209, 233-239.  
1618298 V.Prozorovski, M.Krook, S.Atrian, R.Gonzàlez-Duarte, and H.Jörnvall (1992).
Identification of reactive tyrosine residues in cysteine-reactive dehydrogenases. Differences between liver sorbitol, liver alcohol and Drosophila alcohol dehydrogenases.
  FEBS Lett, 304, 46-50.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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