PDBsum entry 1fea

Oxidoreductase

PDB id: 1fea

Contents

Protein chains

487 a.a. *

Ligands

FAD ×4

Waters ×362

* Residue conservation analysis

PDB id:

1fea

Name:

Oxidoreductase

Title:

Unliganded crithidia fasciculata trypanothione reductase at 2.2 angstrom resolution

Structure:

Trypanothione reductase. Chain: a, b, c, d. Engineered: yes. Other_details: monoclinic crystal form, tetramer in the asymmetric unit

Source:

Crithidia fasciculata. Organism_taxid: 5656. Gene: tr1. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: see strickland, et. Al. (1995) acta cryst. D51, 337- 341

Biol. unit:

Homo-Dimer (from PDB file)

Resolution:

2.20Å R-factor: 0.185

Authors:

C.Strickland,P.Karplus

Key ref:

C.L.Strickland and p.a.karplus Crithidia fasciculata trypanothione reductase at 1.70 a resolution. To be published, .

Date:

12-Jul-95 Release date: 11-Jan-97

Protein chains

P39040  (TYTR_CRIFA) -  Trypanothione reductase from Crithidia fasciculata

Seq: 491 a.a.

Struc: 487 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.1.8.1.12 - trypanothione-disulfide reductase.
• Reaction: trypanothione + NADP⁺ = trypanothione disulfide + NADPH + H⁺
• Cofactor: FAD

FAD (Bound ligand (Het Group name = FAD) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site