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PDBsum entry 1evd
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Hydrolase inhibitor, toxin
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PDB id
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1evd
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PDB id:
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| Name: |
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Hydrolase inhibitor, toxin
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Title:
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Nmr structure of cyanobacterial toxin, phosphatase-1/-2a inhibitor
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Structure:
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Motuporin. Chain: a. Synonym: nodularin-v
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Source:
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Unidentified. Organism_taxid: 32644. Other_details: isolated from marine sponge
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NMR struc:
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1 models
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Authors:
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J.R.Bagu,B.D.Sykes
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Key ref:
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J.R.Bagu
et al.
(1995).
Comparison of the solution structures of microcystin-LR and motuporin.
Nat Struct Biol,
2,
114-116.
PubMed id:
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Date:
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14-Feb-96
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Release date:
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08-Nov-96
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Headers
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References
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Nat Struct Biol
2:114-116
(1995)
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PubMed id:
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Comparison of the solution structures of microcystin-LR and motuporin.
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J.R.Bagu,
F.D.Sönnichsen,
D.Williams,
R.J.Andersen,
B.D.Sykes,
C.F.Holmes.
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ABSTRACT
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A comparison of the structures of two cyanobacterial toxins yields insights into
how they may inhibit protein phosphatase-1 and -2A and why microcystins but not
motuporin may covalently modify their protein phosphatase targets.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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I.Sainis,
D.Fokas,
K.Vareli,
A.G.Tzakos,
V.Kounnis,
and
E.Briasoulis
(2010).
Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs.
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Mar Drugs,
8,
629-657.
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V.Sipiä,
H.Kankaanpää,
K.Lahti,
W.W.Carmichael,
and
J.Meriluoto
(2001).
Detection of nodularin in flounders and cod from the Baltic Sea.
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Environ Toxicol,
16,
121-126.
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P.Lavigne,
J.R.Bagu,
R.Boyko,
L.Willard,
C.F.Holmes,
and
B.D.Sykes
(2000).
Structure-based thermodynamic analysis of the dissociation of protein phosphatase-1 catalytic subunit and microcystin-LR docked complexes.
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Protein Sci,
9,
252-264.
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D.Barford,
A.K.Das,
and
M.P.Egloff
(1998).
The structure and mechanism of protein phosphatases: insights into catalysis and regulation.
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Annu Rev Biophys Biomol Struct,
27,
133-164.
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S.J.Stone,
Z.Cui,
and
J.E.Vance
(1998).
Cloning and expression of mouse liver phosphatidylserine synthase-1 cDNA. Overexpression in rat hepatoma cells inhibits the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis.
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J Biol Chem,
273,
7293-7302.
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C.M.Gauss,
J.E.Sheppeck,
A.C.Nairn,
and
R.Chamberlin
(1997).
A molecular modeling analysis of the binding interactions between the okadaic acid class of natural product inhibitors and the Ser-Thr phosphatases, PP1 and PP2A.
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Bioorg Med Chem,
5,
1751-1773.
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D.Barford
(1996).
Molecular mechanisms of the protein serine/threonine phosphatases.
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Trends Biochem Sci,
21,
407-412.
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D.G.Bourne,
G.J.Jones,
R.L.Blakeley,
A.Jones,
A.P.Negri,
and
P.Riddles
(1996).
Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR.
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Appl Environ Microbiol,
62,
4086-4094.
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M.Craig,
H.A.Luu,
T.L.McCready,
D.Williams,
R.J.Andersen,
and
C.F.Holmes
(1996).
Molecular mechanisms underlying he interaction of motuporin and microcystins with type-1 and type-2A protein phosphatases.
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Biochem Cell Biol,
74,
569-578.
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D.Barford
(1995).
Protein phosphatases.
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Curr Opin Struct Biol,
5,
728-734.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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