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PDBsum entry 1esl
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Cell adhesion protein PDB id
1esl

 

 

 

 

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Contents
Protein chain
157 a.a. *
Metals
_CL ×2
_CA ×3
Waters ×112
* Residue conservation analysis
PDB id:
1esl
Name: Cell adhesion protein
Title: Insight into e-selectin(slash)ligand interaction from the crystal structure and mutagenesis of the lec(slash)egf domains
Structure: Human e-selectin. Chain: a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: cho
Resolution:
2.00Å     R-factor:   0.164     R-free:   0.239
Authors: B.J.Graves,R.L.Crowther
Key ref: B.J.Graves et al. (1994). Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains. Nature, 367, 532-538. PubMed id: 7509040
Date:
03-Jun-94     Release date:   31-Aug-94    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P16581  (LYAM2_HUMAN) -  E-selectin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		610 a.a.
157 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
Nature 367:532-538 (1994)
PubMed id: 7509040  
 
 
Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.
B.J.Graves, R.L.Crowther, C.Chandran, J.M.Rumberger, S.Li, K.S.Huang, D.H.Presky, P.C.Familletti, B.A.Wolitzky, D.K.Burns.
 
  ABSTRACT  
 
The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21041668 J.Dernedde, A.Rausch, M.Weinhart, S.Enders, R.Tauber, K.Licha, M.Schirner, U.Zügel, A.von Bonin, and R.Haag (2010).
Dendritic polyglycerol sulfates as multivalent inhibitors of inflammation.
  Proc Natl Acad Sci U S A, 107, 19679-19684.  
19575676 R.P.McEver, and C.Zhu (2010).
Rolling cell adhesion.
  Annu Rev Cell Dev Biol, 26, 363-396.  
19572737 J.Liang, and J.M.Fernández (2009).
Mechanochemistry: One Bond at a Time.
  ACS Nano, 3, 1628-1645.  
19089612 J.Mitoma, T.Miyazaki, M.Sutton-Smith, M.Suzuki, H.Saito, J.C.Yeh, T.Kawano, O.Hindsgaul, P.H.Seeberger, M.Panico, S.M.Haslam, H.R.Morris, R.D.Cummings, A.Dell, and M.Fukuda (2009).
The N-glycolyl form of mouse sialyl Lewis X is recognized by selectins but not by HECA-452 and FH6 antibodies that were raised against human cells.
  Glycoconj J, 26, 511-523.  
19118197 T.A.Springer (2009).
Structural basis for selectin mechanochemistry.
  Proc Natl Acad Sci U S A, 106, 91-96.  
18299992 C.Zhu, T.Yago, J.Lou, V.I.Zarnitsyna, and R.P.McEver (2008).
Mechanisms for flow-enhanced cell adhesion.
  Ann Biomed Eng, 36, 604-621.  
19009103 I.Papp, J.Dernedde, S.Enders, and R.Haag (2008).
Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior.
  Chem Commun (Camb), (), 5851-5853.  
18687680 J.P.Gourdine, G.Cioci, L.Miguet, C.Unverzagt, D.V.Silva, A.Varrot, C.Gautier, E.J.Smith-Ravin, and A.Imberty (2008).
High affinity interaction between a bivalve C-type lectin and a biantennary complex-type N-glycan revealed by crystallography and microcalorimetry.
  J Biol Chem, 283, 30112-30120.
PDB codes: 2vuv 2vuz
17699745 I.Y.Oh, C.H.Yoon, J.Hur, J.H.Kim, T.Y.Kim, C.S.Lee, K.W.Park, I.H.Chae, B.H.Oh, Y.B.Park, and H.S.Kim (2007).
Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle.
  Blood, 110, 3891-3899.  
17142266 J.Lou, and C.Zhu (2007).
A structure-based sliding-rebinding mechanism for catch bonds.
  Biophys J, 92, 1471-1485.  
17567583 P.Aprikian, V.Tchesnokova, B.Kidd, O.Yakovenko, V.Yarov-Yarovoy, E.Trinchina, V.Vogel, W.Thomas, and E.Sokurenko (2007).
Interdomain interaction in the FimH adhesin of Escherichia coli regulates the affinity to mannose.
  J Biol Chem, 282, 23437-23446.  
18028011 S.R.Barthel, J.D.Gavino, L.Descheny, and C.J.Dimitroff (2007).
Targeting selectins and selectin ligands in inflammation and cancer.
  Expert Opin Ther Targets, 11, 1473-1491.  
16645035 A.P.Wiita, S.R.Ainavarapu, H.H.Huang, and J.M.Fernandez (2006).
Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques.
  Proc Natl Acad Sci U S A, 103, 7222-7227.  
16765898 B.A.Wurzburg, S.S.Tarchevskaya, and T.S.Jardetzky (2006).
Structural changes in the lectin domain of CD23, the low-affinity IgE receptor, upon calcium binding.
  Structure, 14, 1049-1058.
PDB codes: 2h2r 2h2t
16567809 E.M.Ward, N.S.Stambach, K.Drickamer, and M.E.Taylor (2006).
Polymorphisms in human langerin affect stability and sugar binding activity.
  J Biol Chem, 281, 15450-15456.  
17000883 J.Lou, T.Yago, A.G.Klopocki, P.Mehta, W.Chen, V.I.Zarnitsyna, N.V.Bovin, C.Zhu, and R.P.McEver (2006).
Flow-enhanced adhesion regulated by a selectin interdomain hinge.
  J Cell Biol, 174, 1107-1117.  
16845394 U.T.Phan, T.T.Waldron, and T.A.Springer (2006).
Remodeling of the lectin-EGF-like domain interface in P- and L-selectin increases adhesiveness and shear resistance under hydrodynamic force.
  Nat Immunol, 7, 883-889.  
16336259 A.N.Zelensky, and J.E.Gready (2005).
The C-type lectin-like domain superfamily.
  FEBS J, 272, 6179-6217.  
15813660 S.J.Romano (2005).
Selectin antagonists : therapeutic potential in asthma and COPD.
  Treat Respir Med, 4, 85-94.  
14711836 W.Liu, L.Tang, G.Zhang, H.Wei, Y.Cui, L.Guo, Z.Gou, X.Chen, D.Jiang, Y.Zhu, G.Kang, and F.He (2004).
Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.
  J Biol Chem, 279, 18748-18758.  
15148373 Y.Yu, K.S.Moulton, M.K.Khan, S.Vineberg, E.Boye, V.M.Davis, P.E.O'Donnell, J.Bischoff, and D.S.Milstone (2004).
E-selectin is required for the antiangiogenic activity of endostatin.
  Proc Natl Acad Sci U S A, 101, 8005-8010.  
12493733 S.C.Garman, W.N.Simcoke, A.W.Stowers, and D.N.Garboczi (2003).
Structure of the C-terminal domains of merozoite surface protein-1 from Plasmodium knowlesi reveals a novel histidine binding site.
  J Biol Chem, 278, 7264-7269.
PDB code: 1n1i
12399458 L.East, S.Rushton, M.E.Taylor, and C.M.Isacke (2002).
Characterization of sugar binding by the mannose receptor family member, Endo180.
  J Biol Chem, 277, 50469-50475.  
12369089 N.Kaila, and B.E.Thomas (2002).
Design and synthesis of sialyl Lewis(x) mimics as E- and P-selectin inhibitors.
  Med Res Rev, 22, 566-601.  
11782016 R.M.Rao, J.L.Clarke, S.Ortlepp, M.K.Robinson, R.C.Landis, and D.O.Haskard (2002).
The S128R polymorphism of E-selectin mediates neuraminidase-resistant tethering of myeloid cells under shear flow.
  Eur J Immunol, 32, 251-260.  
11866098 T.Hatakeyama, N.Matsuo, K.Shiba, S.Nishinohara, N.Yamasaki, H.Sugawara, and H.Aoyagi (2002).
Amino acid sequence and carbohydrate-binding analysis of the N-acetyl-D-galactosamine-specific C-type lectin, CEL-I, from the Holothuroidea, Cucumaria echinata.
  Biosci Biotechnol Biochem, 66, 157-163.  
12324413 Y.Zhang, and S.Neelamegham (2002).
Estimating the efficiency of cell capture and arrest in flow chambers: study of neutrophil binding via E-selectin and ICAM-1.
  Biophys J, 83, 1934-1952.  
11785767 H.Kogelberg, and T.Feizi (2001).
New structural insights into lectin-type proteins of the immune system.
  Curr Opin Struct Biol, 11, 635-643.  
11206447 N.Kaila, B.E.Thomas, P.Thakker, J.C.Alvarez, R.T.Camphausen, and D.Crommie (2001).
Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors.
  Bioorg Med Chem Lett, 11, 151-155.  
  11294894 P.Bono, K.Rubin, J.M.Higgins, and R.O.Hynes (2001).
Layilin, a novel integral membrane protein, is a hyaluronan receptor.
  Mol Biol Cell, 12, 891-900.  
11746888 R.Zeng, Q.Xu, X.X.Shao, K.Y.Wang, and Q.C.Xia (2001).
Determination of the disulfide bond pattern of a novel C-type lectin from snake venom by mass spectrometry.
  Rapid Commun Mass Spectrom, 15, 2213-2220.  
11165170 S.Hemmerich (2001).
Carbohydrate sulfotransferases: novel therapeutic targets for inflammation, viral infection and cancer.
  Drug Discov Today, 6, 27-35.  
10737932 J.Bajorath (2000).
Molecular organization, structural features, and ligand binding characteristics of CD44, a highly variable cell surface glycoprotein with multiple functions.
  Proteins, 39, 103-111.  
  11045608 K.Håkansson, and K.B.Reid (2000).
Collectin structure: a review.
  Protein Sci, 9, 1607-1617.  
10835344 M.Batchelor, S.Prasannan, S.Daniell, S.Reece, I.Connerton, G.Bloomberg, G.Dougan, G.Frankel, and S.Matthews (2000).
Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli.
  EMBO J, 19, 2452-2464.
PDB codes: 1e1b 1e5u
11081633 W.S.Somers, J.Tang, G.D.Shaw, and R.T.Camphausen (2000).
Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
  Cell, 103, 467-479.
PDB codes: 1g1q 1g1r 1g1s 1g1t
10075923 C.Ohyama, S.Tsuboi, and M.Fukuda (1999).
Dual roles of sialyl Lewis X oligosaccharides in tumor metastasis and rejection by natural killer cells.
  EMBO J, 18, 1516-1525.  
10023772 J.C.Boyington, A.N.Riaz, A.Patamawenu, J.E.Coligan, A.G.Brooks, and P.D.Sun (1999).
Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors.
  Immunity, 10, 75-82.
PDB code: 1b6e
10380930 J.H.Wang, A.Smolyar, K.Tan, J.H.Liu, M.Kim, Z.Y.Sun, G.Wagner, and E.L.Reinherz (1999).
Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.
  Cell, 97, 791-803.
PDB code: 1qa9
10508765 K.Drickamer (1999).
C-type lectin-like domains.
  Curr Opin Struct Biol, 9, 585-590.  
10359109 K.Goda, T.Tanaka, M.Monden, and M.Miyasaka (1999).
Characterization of an apparently conserved epitope in E- and P-selectin identified by dual-specific monoclonal antibodies.
  Eur J Immunol, 29, 1551-1560.  
10368295 K.Håkansson, N.K.Lim, H.J.Hoppe, and K.B.Reid (1999).
Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D.
  Structure, 7, 255-264.
PDB code: 1b08
10081901 K.Skorstengaard, E.M.Vestergaard, N.C.Langkilde, L.L.Christensen, H.Wolf, and T.F.Orntoft (1999).
Lewis antigen mediated adhesion of freshly removed human bladder tumors to E-selectin.
  J Urol, 161, 1316-1323.  
10585960 M.J.Smith, E.L.Berg, and M.B.Lawrence (1999).
A direct comparison of selectin-mediated transient, adhesive events using high temporal resolution.
  Biophys J, 77, 3371-3383.  
9885254 S.Chen, and T.A.Springer (1999).
An automatic braking system that stabilizes leukocyte rolling by an increase in selectin bond number with shear.
  J Cell Biol, 144, 185-200.  
9466983 A.Koenig, K.Norgard-Sumnicht, R.Linhardt, and A.Varki (1998).
Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
  J Clin Invest, 101, 877-889.  
9692950 A.Muranyi, B.E.Finn, G.P.Gippert, S.Forsén, J.Stenflo, and T.Drakenberg (1998).
Solution structure of the N-terminal EGF-like domain from human factor VII.
  Biochemistry, 37, 10605-10615.
PDB code: 1bf9
9660955 A.P.May, R.C.Robinson, M.Vinson, P.R.Crocker, and E.Y.Jones (1998).
Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution.
  Mol Cell, 1, 719-728.
PDB codes: 1qfo 1qfp
9565600 A.Rodríguez-Romero, O.Almog, M.Tordova, Z.Randhawa, and G.L.Gilliland (1998).
Primary and tertiary structures of the Fab fragment of a monoclonal anti-E-selectin 7A9 antibody that inhibits neutrophil attachment to endothelial cells.
  J Biol Chem, 273, 11770-11775.
PDB code: 1a5f
9477945 B.Bersch, J.F.Hernandez, D.Marion, and G.J.Arlaud (1998).
Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family.
  Biochemistry, 37, 1204-1214.
PDB code: 1apq
9497351 D.Torgersen, N.P.Mullin, and K.Drickamer (1998).
Mechanism of ligand binding to E- and P-selectin analyzed using selectin/mannose-binding protein chimeras.
  J Biol Chem, 273, 6254-6261.  
9501087 E.Hohenester, T.Sasaki, B.R.Olsen, and R.Timpl (1998).
Crystal structure of the angiogenesis inhibitor endostatin at 1.5 A resolution.
  EMBO J, 17, 1656-1664.
PDB code: 1koe
9417085 J.Bajorath, B.Greenfield, S.B.Munro, A.J.Day, and A.Aruffo (1998).
Identification of CD44 residues important for hyaluronan binding and delineation of the binding site.
  J Biol Chem, 273, 338-343.  
9922165 K.K.Ng, S.Park-Snyder, and W.I.Weis (1998).
Ca2+-dependent structural changes in C-type mannose-binding proteins.
  Biochemistry, 37, 17965-17976.
PDB codes: 1buu 1bv4
9922166 K.K.Ng, and W.I.Weis (1998).
Coupling of prolyl peptide bond isomerization and Ca2+ binding in a C-type mannose-binding protein.
  Biochemistry, 37, 17977-17989.  
9521729 K.V.Ewart, Z.Li, D.S.Yang, G.L.Fletcher, and C.L.Hew (1998).
The ice-binding site of Atlantic herring antifreeze protein corresponds to the carbohydrate-binding site of C-type lectins.
  Biochemistry, 37, 4080-4085.  
  9521122 M.Gerstein, and M.Levitt (1998).
Comprehensive assessment of automatic structural alignment against a manual standard, the scop classification of proteins.
  Protein Sci, 7, 445-456.  
9695813 M.J.Humphries, and P.Newham (1998).
The structure of cell-adhesion molecules.
  Trends Cell Biol, 8, 78-83.  
9786953 M.L.Borowsky, and R.O.Hynes (1998).
Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles.
  J Cell Biol, 143, 429-442.  
9632659 M.L.van de Poll, M.J.van Vugt, A.E.Lenferink, and E.J.van Zoelen (1998).
Identification of the minimal requirements for binding to the human epidermal growth factor (EGF) receptor using chimeras of human EGF and an EGF repeat of Drosophila Notch.
  J Biol Chem, 273, 16075-16081.  
  9627680 P.M.Sass (1998).
The involvement of selectins in cell adhesion, tumor progression, and metastasis.
  Cancer Invest, 16, 322-328.  
9842918 S.Butcher, K.L.Arney, and G.P.Cook (1998).
MAFA-L, an ITIM-containing receptor encoded by the human NK cell gene complex and expressed by basophils and NK cells.
  Eur J Immunol, 28, 3755-3762.  
  9521098 S.Jones, M.Stewart, A.Michie, M.B.Swindells, C.Orengo, and J.M.Thornton (1998).
Domain assignment for protein structures using a consensus approach: characterization and analysis.
  Protein Sci, 7, 233-242.  
9799507 S.L.Schwager, A.J.Chubb, R.R.Scholle, W.F.Brandt, C.Eckerskorn, E.D.Sturrock, and M.R.Ehlers (1998).
Phorbol ester-induced juxtamembrane cleavage of angiotensin-converting enzyme is not inhibited by a stalk containing intrachain disulfides.
  Biochemistry, 37, 15449-15456.  
9537986 W.Gronwald, M.C.Loewen, B.Lix, A.J.Daugulis, F.D.Sönnichsen, P.L.Davies, and B.D.Sykes (1998).
The solution structure of type II antifreeze protein reveals a new member of the lectin family.
  Biochemistry, 37, 4712-4721.
PDB code: 2afp
9700499 W.I.Weis, M.E.Taylor, and K.Drickamer (1998).
The C-type lectin superfamily in the immune system.
  Immunol Rev, 163, 19-34.  
9724722 Y.H.Ding, K.Javaherian, K.M.Lo, R.Chopra, T.Boehm, J.Lanciotti, B.A.Harris, Y.Li, R.Shapiro, E.Hohenester, R.Timpl, J.Folkman, and D.C.Wiley (1998).
Zinc-dependent dimers observed in crystals of human endostatin.
  Proc Natl Acad Sci U S A, 95, 10443-10448.
PDB code: 1bnl
9345618 A.Imberty (1997).
Oligosaccharide structures: theory versus experiment.
  Curr Opin Struct Biol, 7, 617-623.  
9059883 F.Takei, J.Brennan, and D.L.Mager (1997).
The Ly-49 family: genes, proteins and recognition of class I MHC.
  Immunol Rev, 155, 67-77.  
9057819 H.J.Gabius (1997).
Animal lectins.
  Eur J Biochem, 243, 543-576.  
9187649 H.Mizuno, Z.Fujimoto, M.Koizumi, H.Kano, H.Atoda, and T.Morita (1997).
Structure of coagulation factors IX/X-binding protein, a heterodimer of C-type lectin domains.
  Nat Struct Biol, 4, 438-441.
PDB code: 1ixx
9218785 J.Rossjohn, J.T.Buckley, B.Hazes, A.G.Murzin, R.J.Read, and M.W.Parker (1997).
Aerolysin and pertussis toxin share a common receptor-binding domain.
  EMBO J, 16, 3426-3434.  
9033386 K.K.Ng, and W.I.Weis (1997).
Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides.
  Biochemistry, 36, 979-988.
PDB codes: 1kmb 2kmb 3kmb 4kmb
9092813 M.Lohmeyer, P.M.Harrison, S.Kannan, M.DeSantis, N.J.O'Reilly, M.J.Sternberg, D.S.Salomon, and W.J.Gullick (1997).
Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human cripto.
  Biochemistry, 36, 3837-3845.  
9038177 N.P.Mullin, P.G.Hitchen, and M.E.Taylor (1997).
Mechanism of Ca2+ and monosaccharide binding to a C-type carbohydrate-recognition domain of the macrophage mannose receptor.
  J Biol Chem, 272, 5668-5681.  
9281593 R.Alon, S.Chen, K.D.Puri, E.B.Finger, and T.A.Springer (1997).
The kinetics of L-selectin tethers and the mechanics of selectin-mediated rolling.
  J Cell Biol, 138, 1169-1180.  
9334739 T.R.Transue, A.K.Smith, H.Mo, I.J.Goldstein, and M.A.Saper (1997).
Structure of benzyl T-antigen disaccharide bound to Amaranthus caudatus agglutinin.
  Nat Struct Biol, 4, 779-783.
PDB codes: 1jlx 1jly
9345619 W.I.Weis (1997).
Cell-surface carbohydrate recognition by animal and viral lectins.
  Curr Opin Struct Biol, 7, 624-630.  
8663282 B.M.Revelle, D.Scott, and P.J.Beck (1996).
Single amino acid residues in the E- and P-selectin epidermal growth factor domains can determine carbohydrate binding specificity.
  J Biol Chem, 271, 16160-16170.  
8626776 B.M.Revelle, D.Scott, T.P.Kogan, J.Zheng, and P.J.Beck (1996).
Structure-function analysis of P-selectin-sialyl LewisX binding interactions. Mutagenic alteration of ligand binding specificity.
  J Biol Chem, 271, 4289-4297.  
8816772 C.E.White, M.J.Hunter, D.P.Meininger, S.Garrod, and E.A.Komives (1996).
The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern.
  Proc Natl Acad Sci U S A, 93, 10177-10182.  
8913627 D.K.Brunk, D.J.Goetz, and D.A.Hammer (1996).
Sialyl Lewis(x)/E-selectin-mediated rolling in a cell-free system.
  Biophys J, 71, 2902-2907.  
8797823 D.Kohda, C.J.Morton, A.A.Parkar, H.Hatanaka, F.M.Inagaki, I.D.Campbell, and A.J.Day (1996).
Solution structure of the link module: a hyaluronan-binding domain involved in extracellular matrix stability and cell migration.
  Cell, 86, 767-775.
PDB code: 1tsg
8806082 D.Vestweber (1996).
Ligand-specificity of the selectins.
  J Cell Biochem, 61, 585-591.  
8939654 E.Y.Jones (1996).
Three-dimensional structure of cell adhesion molecules.
  Curr Opin Cell Biol, 8, 602-608.  
8639584 F.Kolbinger, J.T.Patton, G.Geisenhoff, A.Aenis, X.Li, and A.G.Katopodis (1996).
The carbohydrate-recognition domain of E-selectin is sufficient for ligand binding under both static and flow conditions.
  Biochemistry, 35, 6385-6392.  
  8654365 J.A.Bertrand, D.Pignol, J.P.Bernard, J.M.Verdier, J.C.Dagorn, and J.C.Fontecilla-Camps (1996).
Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.
  EMBO J, 15, 2678-2684.
PDB code: 1lit
  8745401 J.Bajorath, and A.Aruffo (1996).
Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.
  Protein Sci, 5, 240-247.
PDB code: 1kje
8924200 K.C.Chou (1996).
Knowledge-based model building of the tertiary structures for lectin domains of the selectin family.
  J Protein Chem, 15, 161-168.  
8621395 K.D.Puri, and T.A.Springer (1996).
A schiff base with mildly oxidized carbohydrate ligands stabilizes L-selectin and not P-selectin or E-selectin rolling adhesions in shear flow.
  J Biol Chem, 271, 5404-5413.  
8557671 K.K.Ng, K.Drickamer, and W.I.Weis (1996).
Structural analysis of monosaccharide recognition by rat liver mannose-binding protein.
  J Biol Chem, 271, 663-674.
PDB codes: 1rdi 1rdj 1rdk 1rdl 1rdm 1rdn 1rdo
8663288 K.V.Ewart, D.S.Yang, V.S.Ananthanarayanan, G.L.Fletcher, and C.L.Hew (1996).
Ca2+-dependent antifreeze proteins. Modulation of conformation and activity by divalent metal ions.
  J Biol Chem, 271, 16627-16632.  
8702911 K.Wu, J.Yuan, and L.A.Lasky (1996).
Characterization of a novel member of the macrophage mannose receptor type C lectin family.
  J Biol Chem, 271, 21323-21330.  
8794734 M.Sunnerhagen, G.A.Olah, J.Stenflo, S.Forsén, T.Drakenberg, and J.Trewhella (1996).
The relative orientation of Gla and EGF domains in coagulation factor X is altered by Ca2+ binding to the first EGF domain. A combined NMR-small angle X-ray scattering study.
  Biochemistry, 35, 11547-11559.
PDB codes: 1whe 1whf
8913694 M.von Itzstein, and P.Colman (1996).
Design and synthesis of carbohydrate-based inhibitors of protein-carbohydrate interactions.
  Curr Opin Struct Biol, 6, 703-709.  
8939653 P.Maurer, E.Hohenester, and J.Engel (1996).
Extracellular calcium-binding proteins.
  Curr Opin Cell Biol, 8, 609-617.  
8913692 P.R.Crocker, and T.Feizi (1996).
Carbohydrate recognition systems: functional triads in cell-cell interactions.
  Curr Opin Struct Biol, 6, 679-691.  
8901537 P.Sears, and C.H.Wong (1996).
Intervention of carbohydrate recognition by proteins and nucleic acids.
  Proc Natl Acad Sci U S A, 93, 12086-12093.  
  8745396 R.Hrabal, E.A.Komives, and F.Ni (1996).
Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin.
  Protein Sci, 5, 195-203.
PDB codes: 1fgd 1fge
  8845748 R.Tejero, D.Bassolino-Klimas, R.E.Bruccoleri, and G.T.Montelione (1996).
Simulated annealing with restrained molecular dynamics using CONGEN: energy refinement of the NMR solution structures of epidermal and type-alpha transforming growth factors.
  Protein Sci, 5, 578-592.  
8901515 S.J.Freedman, D.G.Sanford, W.W.Bachovchin, B.C.Furie, J.D.Baleja, and B.Furie (1996).
Structure and function of the epidermal growth factor domain of P-selectin.
  Biochemistry, 35, 13733-13744.
PDB code: 1fsb
8910289 S.Tsuboi, Y.Isogai, N.Hada, J.K.King, O.Hindsgaul, and M.Fukuda (1996).
6'-Sulfo sialyl Lex but not 6-sulfo sialyl Lex expressed on the cell surface supports L-selectin-mediated adhesion.
  J Biol Chem, 271, 27213-27216.  
8831987 T.Uchiyama, T.J.Woltering, W.Wong, C.C.Lin, T.Kajimoto, M.Takebayashi, G.Weitz-Schmidt, T.Asakura, M.Noda, and C.H.Wong (1996).
Design and synthesis of C-linked fucosides as inhibitors of E-selectin.
  Bioorg Med Chem, 4, 1149-1165.  
  11725103 Y.C.Lee, and R.T.Lee (1996).
Glycobiology in Medicine.
  J Biomed Sci, 3, 221-237.  
7773783 B.J.Graves (1995).
Integrin binding revealed.
  Nat Struct Biol, 2, 181-183.  
7545665 C.L.Martens, S.E.Cwirla, R.Y.Lee, E.Whitehorn, E.Y.Chen, A.Bakker, E.L.Martin, C.Wagstrom, P.Gopalan, and C.W.Smith (1995).
Peptides which bind to E-selectin and block neutrophil adhesion.
  J Biol Chem, 270, 21129-21136.  
8749360 D.I.Stuart, and E.Y.Jones (1995).
Recognition at the cell surface: recent structural insights.
  Curr Opin Struct Biol, 5, 735-743.  
7592823 D.Nath, P.A.van der Merwe, S.Kelm, P.Bradfield, and P.R.Crocker (1995).
The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22.
  J Biol Chem, 270, 26184-26191.  
  8528067 D.P.Meininger, M.J.Hunter, and E.A.Komives (1995).
Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin.
  Protein Sci, 4, 1683-1695.
PDB code: 1zaq
  7540906 F.D.Sönnichsen, B.D.Sykes, and P.L.Davies (1995).
Comparative modeling of the three-dimensional structure of type II antifreeze protein.
  Protein Sci, 4, 460-471.  
8536711 H.Maaheimo, R.Renkonen, J.P.Turunen, L.Penttilä, and O.Renkonen (1995).
Synthesis of a divalent sialyl Lewis x O-glycan, a potent inhibitor of lymphocyte-endothelium adhesion. Evidence that multivalency enhances the saccharide binding to L-selectin.
  Eur J Biochem, 234, 616-625.  
7664103 K.Drickamer (1995).
Multiplicity of lectin-carbohydrate interactions.
  Nat Struct Biol, 2, 437-439.  
8574696 K.Drickamer (1995).
Increasing diversity of animal lectin structures.
  Curr Opin Struct Biol, 5, 612-616.  
7796258 L.A.Lasky (1995).
From sticky zippers to morphology.
  Nat Struct Biol, 2, 258-261.  
7536194 M.Anostario, and K.S.Huang (1995).
Modulation of E-selectin structure/function by metal ions. Studies on limited proteolysis and metal ion regeneration.
  J Biol Chem, 270, 8138-8144.  
7606382 M.Fukuda (1995).
Carbohydrate-dependent cell adhesion.
  Bioorg Med Chem, 3, 207-215.  
  8535250 M.J.Hunter, and E.A.Komives (1995).
Thrombin-binding affinities of different disulfide-bonded isomers of the fifth EGF-like domain of thrombomodulin.
  Protein Sci, 4, 2129-2137.  
7589110 P.Påhlsson, J.Strindhall, U.Srinivas, and A.Lundblad (1995).
Role of N-linked glycosylation in expression of E-selectin on human endothelial cells.
  Eur J Immunol, 25, 2452-2459.  
7552752 S.E.Greasley, H.Jhoti, C.Teahan, R.Solari, A.Fensome, G.M.Thomas, S.Cockcroft, and B.Bax (1995).
The structure of rat ADP-ribosylation factor-1 (ARF-1) complexed to GDP determined from two different crystal forms.
  Nat Struct Biol, 2, 797-806.
PDB codes: 1rrf 1rrg
7539797 T.P.Kogan, B.M.Revelle, S.Tapp, D.Scott, and P.J.Beck (1995).
A single amino acid residue can determine the ligand specificity of E-selectin.
  J Biol Chem, 270, 14047-14055.  
7519775 A.Varki (1994).
Selectin ligands.
  Proc Natl Acad Sci U S A, 91, 7390-7397.  
7712288 G.Wagner, and D.F.Wyss (1994).
Cell surface adhesion receptors.
  Curr Opin Struct Biol, 4, 841-851.  
7764899 I.D.Campbell, and A.K.Downing (1994).
Building protein structure and function from modular units.
  Trends Biotechnol, 12, 168-172.  
7535138 J.Sandros, E.Rozdzinski, J.Zheng, D.Cowburn, and E.Tuomanen (1994).
Lectin domains in the toxin of Bordetella pertussis: selectin mimicry linked to microbial pathogenesis.
  Glycoconj J, 11, 501-506.  
7544682 L.A.Lasky (1994).
A sweet success.
  Nat Struct Biol, 1, 139-141.  
7541306 M.A.Labow, C.R.Norton, J.M.Rumberger, K.M.Lombard-Gillooly, D.J.Shuster, J.Hubbard, R.Bertko, P.A.Knaack, R.W.Terry, and M.L.Harbison (1994).
Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins.
  Immunity, 1, 709-720.  
7747516 M.Stratford (1994).
Another brick in the wall? Recent developments concerning the yeast cell envelope.
  Yeast, 10, 1741-1752.  
7634099 P.E.Stein, A.Boodhoo, G.D.Armstrong, L.D.Heerze, S.A.Cockle, M.H.Klein, and R.J.Read (1994).
Structure of a pertussis toxin-sugar complex as a model for receptor binding.
  Nat Struct Biol, 1, 591-596.
PDB code: 1pto
7712290 P.M.Colman (1994).
Structure-based drug design.
  Curr Opin Struct Biol, 4, 868-874.  
7521172 R.B.Parekh, and C.J.Edge (1994).
Selectins--glycoprotein targets for therapeutic intervention in inflammation.
  Trends Biotechnol, 12, 339-345.  
7980493 R.O.Hynes (1994).
The impact of molecular biology on models for cell adhesion.
  Bioessays, 16, 663-669.  
7634089 S.Sheriff, C.Y.Chang, and R.A.Ezekowitz (1994).
Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple alpha-helical coiled-coil.
  Nat Struct Biol, 1, 789-794.
PDB code: 1hup
7520818 W.I.Weis (1994).
Lectins on a roll: the structure of E-selectin.
  Structure, 2, 147-150.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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