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Contents |
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272 a.a.
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99 a.a.
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635 a.a.
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* Residue conservation analysis
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PDB id:
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Metal transport inhibitor/receptor
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Title:
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Hemochromatosis protein hfe complexed with transferrin receptor
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Structure:
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Hemochromatosis protein. Chain: a, d, g. Fragment: ectodomain. Synonym: hfe. Engineered: yes. Beta-2-microglobulin. Chain: b, e, h. Engineered: yes. Transferrin receptor.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: ovary cells. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell: high 5 insect cells.
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Biol. unit:
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Hexamer (from PDB file)
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Resolution:
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2.80Å
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R-factor:
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0.231
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R-free:
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0.265
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Authors:
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M.J.Bennett,J.A.Lebron,P.J.Bjorkman
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Key ref:
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M.J.Bennett
et al.
(2000).
Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.
Nature,
403,
46-53.
PubMed id:
DOI:
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Date:
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12-Nov-99
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Release date:
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19-Jan-00
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PROCHECK
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Headers
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References
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Q30201
(HFE_HUMAN) -
Hereditary hemochromatosis protein from Homo sapiens
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Seq:
Struc:
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348 a.a.
272 a.a.
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DOI no:
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Nature
403:46-53
(2000)
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PubMed id:
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Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.
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M.J.Bennett,
J.A.Lebrón,
P.J.Bjorkman.
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ABSTRACT
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HFE is related to major histocompatibility complex (MHC) class I proteins and is
mutated in the iron-overload disease hereditary haemochromatosis. HFE binds to
the transferrin receptor (TfR), a receptor by which cells acquire iron-loaded
transferrin. The 2.8 A crystal structure of a complex between the extracellular
portions of HFE and TfR shows two HFE molecules which grasp each side of a
twofold symmetric TfR dimer. On a cell membrane containing both proteins, HFE
would 'lie down' parallel to the membrane, such that the HFE helices that
delineate the counterpart of the MHC peptide-binding groove make extensive
contacts with helices in the TfR dimerization domain. The structures of TfR
alone and complexed with HFE differ in their domain arrangement and dimer
interfaces, providing a mechanism for communicating binding events between TfR
chains. The HFE-TfR complex suggests a binding site for transferrin on TfR and
sheds light upon the function of HFE in regulating iron homeostasis.
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Selected figure(s)
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Figure 1.
Figure 1: Ribbon diagrams of HFE, TfR and HFE-TfR structures.
a, HFE^5 (PDB code 1A6Z). Residues substituted in HH mutations
(Cys 260 and His 41)3 and a cluster of histidines (residues 87,
89, 94 and 123) are highlighted. An arrow indicates the inward
displacement of  1
domain helix as compared with the analogous class I MHC helix.
b, TfR monomer from homodimer structure^15 (made using
coordinates provided by C. M. Lawrence and S. C. Harrison). A,
apical loop (residues 312-328); PL, protease-like loop (residues
469-476); C tail, C-terminal tail (residues 750-760). c, Two
views of the HFE-TfR structure related by a 90° rotation about
the vertical axis. Chain termini nearest the predicted
transmembrane region (C terminus for HFE heavy chain; N terminus
for TfR) are labelled (left). The membrane bilayer is
represented by a grey box (right).
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Figure 2.
Figure 2: The HFE-TfR interface. Cut away views of a TfR
monomer (a) and the HFE platform (b) from the HFE-TfR structure
are shown with regions containing residues that form contacts
highlighted in gold (HFE) and aqua (TfR). Side chains of
residues identified by site-directed mutagenesis to affect
ligand binding are highlighted on TfR in cyan (Fe-Tf binding28)
and on HFE in red (TfR binding12). c, Representation of HFE-TfR
interface showing the three-helix bundle and kinked portion of
the HFE 2
helix. d, TCR footprint (pink box) on the structure of a class I
MHC molecule. Arrows indicate the 'high points' on the 1
and 2
helices (Based on Fig. 5 in ref. 4).
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The above figures are
reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2000,
403,
46-53)
copyright 2000.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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P.C.Santos,
R.D.Cançado,
A.C.Pereira,
I.T.Schettert,
R.A.Soares,
R.A.Pagliusi,
R.D.Hirata,
M.H.Hirata,
A.C.Teixeira,
M.S.Figueiredo,
C.S.Chiattone,
J.E.Krieger,
and
E.M.Guerra-Shinohara
(2011).
Hereditary hemochromatosis: mutations in genes involved in iron homeostasis in Brazilian patients.
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Blood Cells Mol Dis,
46,
302-307.
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C.S.Hee,
S.Gao,
B.Loll,
M.M.Miller,
B.Uchanska-Ziegler,
O.Daumke,
and
A.Ziegler
(2010).
Structure of a classical MHC class I molecule that binds "non-classical" ligands.
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PLoS Biol,
8,
e1000557.
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PDB codes:
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G.Weiss
(2010).
Genetic mechanisms and modifying factors in hereditary hemochromatosis.
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Nat Rev Gastroenterol Hepatol,
7,
50-58.
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|
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|
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H.Li,
and
Y.Z.Ginzburg
(2010).
Crosstalk between Iron Metabolism and Erythropoiesis.
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Adv Hematol,
2010,
605435.
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|
|
|
|
|
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J.Abraham,
K.D.Corbett,
M.Farzan,
H.Choe,
and
S.C.Harrison
(2010).
Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses.
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Nat Struct Mol Biol,
17,
438-444.
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PDB code:
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J.Gao,
J.Chen,
I.De Domenico,
D.M.Koeller,
C.O.Harding,
R.E.Fleming,
D.D.Koeberl,
and
C.A.Enns
(2010).
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
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Blood,
115,
3374-3381.
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J.L.Babitt,
and
H.Y.Lin
(2010).
Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD.
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Am J Kidney Dis,
55,
726-741.
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|
|
|
|
|
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J.Rochette,
G.Le Gac,
K.Lassoued,
C.Férec,
and
K.J.Robson
(2010).
Factors influencing disease phenotype and penetrance in HFE haemochromatosis.
|
| |
Hum Genet,
128,
233-248.
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|
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|
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L.B.Goodman,
S.M.Lyi,
N.C.Johnson,
J.O.Cifuente,
S.L.Hafenstein,
and
C.R.Parrish
(2010).
Binding site on the transferrin receptor for the parvovirus capsid and effects of altered affinity on cell uptake and infection.
|
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J Virol,
84,
4969-4978.
|
|
|
|
|
|
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L.Bhatt,
C.Murphy,
L.S.O'Driscoll,
M.Carmo-Fonseca,
M.W.McCaffrey,
and
J.V.Fleming
(2010).
N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding.
|
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FEBS J,
277,
3219-3234.
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|
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M.A.Wouters,
S.W.Fan,
and
N.L.Haworth
(2010).
Disulfides as redox switches: from molecular mechanisms to functional significance.
|
| |
Antioxid Redox Signal,
12,
53-91.
|
|
|
|
|
|
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M.Chloupková,
A.S.Zhang,
and
C.A.Enns
(2010).
Stoichiometries of transferrin receptors 1 and 2 in human liver.
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Blood Cells Mol Dis,
44,
28-33.
|
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|
|
|
|
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M.D.Knutson
(2010).
Iron-sensing proteins that regulate hepcidin and enteric iron absorption.
|
| |
Annu Rev Nutr,
30,
149-171.
|
|
|
|
|
|
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A.I.Mendes,
A.Ferro,
R.Martins,
I.Picanço,
S.Gomes,
R.Cerqueira,
M.Correia,
A.R.Nunes,
J.Esteves,
R.Fleming,
and
P.Faustino
(2009).
Non-classical hereditary hemochromatosis in Portugal: novel mutations identified in iron metabolism-related genes.
|
| |
Ann Hematol,
88,
229-234.
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|
|
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|
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C.E.Harbison,
S.M.Lyi,
W.S.Weichert,
and
C.R.Parrish
(2009).
Early steps in cell infection by parvoviruses: host-specific differences in cell receptor binding but similar endosomal trafficking.
|
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J Virol,
83,
10504-10514.
|
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|
|
|
|
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C.J.Shatz
(2009).
MHC class I: an unexpected role in neuronal plasticity.
|
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Neuron,
64,
40-45.
|
|
|
|
|
|
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E.Corradini,
C.Garuti,
G.Montosi,
P.Ventura,
B.Andriopoulos,
H.Y.Lin,
A.Pietrangelo,
and
J.L.Babitt
(2009).
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis.
|
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Gastroenterology,
137,
1489-1497.
|
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|
|
|
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J.Gao,
J.Chen,
M.Kramer,
H.Tsukamoto,
A.S.Zhang,
and
C.A.Enns
(2009).
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.
|
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Cell Metab,
9,
217-227.
|
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|
|
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|
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L.Kautz,
D.Meynard,
C.Besson-Fournier,
V.Darnaud,
T.Al Saati,
H.Coppin,
and
M.P.Roth
(2009).
BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression.
|
| |
Blood,
114,
2515-2520.
|
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|
|
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|
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N.G.James,
S.L.Byrne,
and
A.B.Mason
(2009).
Incorporation of 5-hydroxytryptophan into transferrin and its receptor allows assignment of the pH induced changes in intrinsic fluorescence when iron is released.
|
| |
Biochim Biophys Acta,
1794,
532-540.
|
|
|
|
|
|
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B.A.Rabinovich,
R.R.Ketchem,
M.Wolfson,
L.Goldstein,
M.Skelly,
and
D.Cosman
(2008).
A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing.
|
| |
Immunol Cell Biol,
86,
489-496.
|
|
|
|
|
|
|
K.Pantopoulos
(2008).
Function of the hemochromatosis protein HFE: Lessons from animal models.
|
| |
World J Gastroenterol,
14,
6893-6901.
|
|
|
|
|
|
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M.U.Muckenthaler,
B.Galy,
and
M.W.Hentze
(2008).
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.
|
| |
Annu Rev Nutr,
28,
197-213.
|
|
|
|
|
|
|
N.C.Andrews
(2008).
Forging a field: the golden age of iron biology.
|
| |
Blood,
112,
219-230.
|
|
|
|
|
|
|
P.J.Schmidt,
P.T.Toran,
A.M.Giannetti,
P.J.Bjorkman,
and
N.C.Andrews
(2008).
The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.
|
| |
Cell Metab,
7,
205-214.
|
|
|
|
|
|
|
S.R.Radoshitzky,
J.H.Kuhn,
C.F.Spiropoulou,
C.G.Albariño,
D.P.Nguyen,
J.Salazar-Bravo,
T.Dorfman,
A.S.Lee,
E.Wang,
S.R.Ross,
H.Choe,
and
M.Farzan
(2008).
Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses.
|
| |
Proc Natl Acad Sci U S A,
105,
2664-2669.
|
|
|
|
|
|
|
W.Held,
and
R.A.Mariuzza
(2008).
Cis interactions of immunoreceptors with MHC and non-MHC ligands.
|
| |
Nat Rev Immunol,
8,
269-278.
|
|
|
|
|
|
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F.A.Arosa,
S.G.Santos,
and
S.J.Powis
(2007).
Open conformers: the hidden face of MHC-I molecules.
|
| |
Trends Immunol,
28,
115-123.
|
|
|
|
|
|
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J.Chen,
M.Chloupková,
J.Gao,
T.L.Chapman-Arvedson,
and
C.A.Enns
(2007).
HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions.
|
| |
J Biol Chem,
282,
36862-36870.
|
|
|
|
|
|
|
J.Holoshitz,
and
S.Ling
(2007).
Nitric oxide signaling triggered by the rheumatoid arthritis shared epitope: a new paradigm for MHC disease association?
|
| |
Ann N Y Acad Sci,
1110,
73-83.
|
|
|
|
|
|
|
L.A.Lambert,
and
S.L.Mitchell
(2007).
Molecular evolution of the transferrin receptor/glutamate carboxypeptidase II family.
|
| |
J Mol Evol,
64,
113-128.
|
|
|
|
|
|
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M.Cukjati,
S.Koren,
V.Curin Serbec,
B.Vidan-Jeras,
and
R.Rupreht
(2007).
A novel homozygous frameshift deletion c.471del of HFE associated with hemochromatosis.
|
| |
Clin Genet,
71,
350-353.
|
|
|
|
|
|
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M.G.Rossmann,
F.Arisaka,
A.J.Battisti,
V.D.Bowman,
P.R.Chipman,
A.Fokine,
S.Hafenstein,
S.Kanamaru,
V.A.Kostyuchenko,
V.V.Mesyanzhinov,
M.M.Shneider,
M.C.Morais,
P.G.Leiman,
L.M.Palermo,
C.R.Parrish,
and
C.Xiao
(2007).
From structure of the complex to understanding of the biology.
|
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Acta Crystallogr D Biol Crystallogr,
63,
9.
|
|
|
|
|
|
|
P.S.Oates,
and
U.Ahmed
(2007).
Molecular regulation of hepatic expression of iron regulatory hormone hepcidin.
|
| |
J Gastroenterol Hepatol,
22,
1378-1387.
|
|
|
|
|
|
|
S.Hafenstein,
L.M.Palermo,
V.A.Kostyuchenko,
C.Xiao,
M.C.Morais,
C.D.Nelson,
V.D.Bowman,
A.J.Battisti,
P.R.Chipman,
C.R.Parrish,
and
M.G.Rossmann
(2007).
Asymmetric binding of transferrin receptor to parvovirus capsids.
|
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Proc Natl Acad Sci U S A,
104,
6585-6589.
|
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PDB code:
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D.Berg,
H.Hochstrasser,
K.J.Schweitzer,
and
O.Riess
(2006).
Disturbance of iron metabolism in Parkinson's disease -- ultrasonography as a biomarker.
|
| |
Neurotox Res,
9,
1.
|
|
|
|
|
|
|
E.Wang,
L.Albritton,
and
S.R.Ross
(2006).
Identification of the segments of the mouse transferrin receptor 1 required for mouse mammary tumor virus infection.
|
| |
J Biol Chem,
281,
10243-10249.
|
|
|
|
|
|
|
J.R.Mesters,
C.Barinka,
W.Li,
T.Tsukamoto,
P.Majer,
B.S.Slusher,
J.Konvalinka,
and
R.Hilgenfeld
(2006).
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
|
| |
EMBO J,
25,
1375-1384.
|
|
|
PDB codes:
|
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|
|
|
|
|
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J.Wally,
P.J.Halbrooks,
C.Vonrhein,
M.A.Rould,
S.J.Everse,
A.B.Mason,
and
S.K.Buchanan
(2006).
The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding.
|
| |
J Biol Chem,
281,
24934-24944.
|
|
|
PDB codes:
|
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|
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|
|
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L.M.Palermo,
S.L.Hafenstein,
and
C.R.Parrish
(2006).
Purified feline and canine transferrin receptors reveal complex interactions with the capsids of canine and feline parvoviruses that correspond to their host ranges.
|
| |
J Virol,
80,
8482-8492.
|
|
|
|
|
|
|
S.Ling,
A.Lai,
O.Borschukova,
P.Pumpens,
and
J.Holoshitz
(2006).
Activation of nitric oxide signaling by the rheumatoid arthritis shared epitope.
|
| |
Arthritis Rheum,
54,
3423-3432.
|
|
|
|
|
|
|
T.Goswami,
and
N.C.Andrews
(2006).
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
|
| |
J Biol Chem,
281,
28494-28498.
|
|
|
|
|
|
|
A.M.Giannetti,
P.J.Halbrooks,
A.B.Mason,
T.M.Vogt,
C.A.Enns,
and
P.J.Björkman
(2005).
The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.
|
| |
Structure,
13,
1613-1623.
|
|
|
|
|
|
|
E.M.Teh,
J.Hewitt,
K.C.Ung,
T.A.Griffiths,
V.Nguyen,
S.K.Briggs,
A.B.Mason,
and
R.T.MacGillivray
(2005).
Identification of the epitope of a monoclonal antibody that disrupts binding of human transferrin to the human transferrin receptor.
|
| |
FEBS J,
272,
6344-6353.
|
|
|
|
|
|
|
J.W.Yewdell,
and
H.D.Hickman-Miller
(2005).
Back to the fold: T cell recognition of HFE, a MHC class Ib molecule that regulates iron metabolism.
|
| |
Proc Natl Acad Sci U S A,
102,
12649-12650.
|
|
|
|
|
|
|
M.I.Davis,
M.J.Bennett,
L.M.Thomas,
and
P.J.Bjorkman
(2005).
Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase.
|
| |
Proc Natl Acad Sci U S A,
102,
5981-5986.
|
|
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PDB code:
|
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|
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|
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P.S.Rohrlich,
N.Fazilleau,
F.Ginhoux,
H.Firat,
F.Michel,
M.Cochet,
N.Laham,
M.P.Roth,
S.Pascolo,
F.Nato,
H.Coppin,
P.Charneau,
O.Danos,
O.Acuto,
R.Ehrlich,
J.Kanellopoulos,
and
F.A.Lemonnier
(2005).
Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function.
|
| |
Proc Natl Acad Sci U S A,
102,
12855-12860.
|
|
|
|
|
|
|
S.Huang,
S.Gilfillan,
M.Cella,
M.J.Miley,
O.Lantz,
L.Lybarger,
D.H.Fremont,
and
T.H.Hansen
(2005).
Evidence for MR1 antigen presentation to mucosal-associated invariant T cells.
|
| |
J Biol Chem,
280,
21183-21193.
|
|
|
|
|
|
|
S.Kasibhatla,
K.A.Jessen,
S.Maliartchouk,
J.Y.Wang,
N.M.English,
J.Drewe,
L.Qiu,
S.P.Archer,
A.E.Ponce,
N.Sirisoma,
S.Jiang,
H.Z.Zhang,
K.R.Gehlsen,
S.X.Cai,
D.R.Green,
and
B.Tseng
(2005).
A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid.
|
| |
Proc Natl Acad Sci U S A,
102,
12095-12100.
|
|
|
|
|
|
|
S.Ludwiczek,
I.Theurl,
S.Bahram,
K.Schümann,
and
G.Weiss
(2005).
Regulatory networks for the control of body iron homeostasis and their dysregulation in HFE mediated hemochromatosis.
|
| |
J Cell Physiol,
204,
489-499.
|
|
|
|
|
|
|
A.M.Giannetti,
and
P.J.Björkman
(2004).
HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface.
|
| |
J Biol Chem,
279,
25866-25875.
|
|
|
|
|
|
|
H.Kawabata,
X.Tong,
T.Kawanami,
Y.Wano,
Y.Hirose,
S.Sugai,
and
H.P.Koeffler
(2004).
Analyses for binding of the transferrin family of proteins to the transferrin receptor 2.
|
| |
Br J Haematol,
127,
464-473.
|
|
|
|
|
|
|
K.Hueffer,
L.M.Palermo,
and
C.R.Parrish
(2004).
Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains.
|
| |
J Virol,
78,
5601-5611.
|
|
|
|
|
|
|
K.J.Livesey,
V.L.Wimhurst,
K.Carter,
M.Worwood,
E.Cadet,
J.Rochette,
A.G.Roberts,
J.J.Pointon,
A.T.Merryweather-Clarke,
M.L.Bassett,
A.M.Jouanolle,
A.Mosser,
V.David,
J.Poulton,
and
K.J.Robson
(2004).
The 16189 variant of mitochondrial DNA occurs more frequently in C282Y homozygotes with haemochromatosis than those without iron loading.
|
| |
J Med Genet,
41,
6.
|
|
|
|
|
|
|
M.W.Hentze,
M.U.Muckenthaler,
and
N.C.Andrews
(2004).
Balancing acts: molecular control of mammalian iron metabolism.
|
| |
Cell,
117,
285-297.
|
|
|
|
|
|
|
N.Laham,
R.Rotem-Yehudar,
C.Shechter,
J.E.Coligan,
and
R.Ehrlich
(2004).
Transferrin [corrected] receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis.
|
| |
J Cell Biochem,
91,
1130-1145.
|
|
|
|
|
|
|
P.Aisen
(2004).
Transferrin receptor 1.
|
| |
Int J Biochem Cell Biol,
36,
2137-2143.
|
|
|
|
|
|
|
U.E.Schaible,
and
S.H.Kaufmann
(2004).
Iron and microbial infection.
|
| |
Nat Rev Microbiol,
2,
946-953.
|
|
|
|
|
|
|
Y.Cheng,
O.Zak,
P.Aisen,
S.C.Harrison,
and
T.Walz
(2004).
Structure of the human transferrin receptor-transferrin complex.
|
| |
Cell,
116,
565-576.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
A.Kumánovics,
T.Takada,
and
K.F.Lindahl
(2003).
Genomic organization of the mammalian MHC.
|
| |
Annu Rev Immunol,
21,
629-657.
|
|
|
|
|
|
|
A.M.Giannetti,
P.M.Snow,
O.Zak,
and
P.J.Björkman
(2003).
Mechanism for multiple ligand recognition by the human transferrin receptor.
|
| |
PLoS Biol,
1,
E51.
|
|
|
|
|
|
|
A.Pietrangelo
(2003).
Haemochromatosis.
|
| |
Gut,
52,
ii23-ii30.
|
|
|
|
|
|
|
A.Pietrangelo
(2003).
Hemochromatosis gene modifies course of hepatitis C viral infection.
|
| |
Gastroenterology,
124,
1509-1523.
|
|
|
|
|
|
|
A.Widera,
F.Norouziyan,
and
W.C.Shen
(2003).
Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery.
|
| |
Adv Drug Deliv Rev,
55,
1439-1466.
|
|
|
|
|
|
|
J.Loconto,
F.Papes,
E.Chang,
L.Stowers,
E.P.Jones,
T.Takada,
A.Kumánovics,
K.Fischer Lindahl,
and
C.Dulac
(2003).
Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules.
|
| |
Cell,
112,
607-618.
|
|
|
|
|
|
|
K.Hueffer,
J.S.Parker,
W.S.Weichert,
R.E.Geisel,
J.Y.Sgro,
and
C.R.Parrish
(2003).
The natural host range shift and subsequent evolution of canine parvovirus resulted from virus-specific binding to the canine transferrin receptor.
|
| |
J Virol,
77,
1718-1726.
|
|
|
|
|
|
|
L.Govindasamy,
K.Hueffer,
C.R.Parrish,
and
M.Agbandje-McKenna
(2003).
Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants.
|
| |
J Virol,
77,
12211-12221.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
L.M.Palermo,
K.Hueffer,
and
C.R.Parrish
(2003).
Residues in the apical domain of the feline and canine transferrin receptors control host-specific binding and cell infection of canine and feline parvoviruses.
|
| |
J Virol,
77,
8915-8923.
|
|
|
|
|
|
|
M.J.Chorney,
Y.Yoshida,
P.N.Meyer,
M.Yoshida,
and
G.S.Gerhard
(2003).
The enigmatic role of the hemochromatosis protein (HFE) in iron absorption.
|
| |
Trends Mol Med,
9,
118-125.
|
|
|
|
|
|
|
R.Liu,
J.Q.Guan,
O.Zak,
P.Aisen,
and
M.R.Chance
(2003).
Structural reorganization of the transferrin C-lobe and transferrin receptor upon complex formation: the C-lobe binds to the receptor helical domain.
|
| |
Biochemistry,
42,
12447-12454.
|
|
|
|
|
|
|
S.Kotamraju,
Y.Tampo,
A.Keszler,
C.R.Chitambar,
J.Joseph,
A.L.Haas,
and
B.Kalyanaraman
(2003).
Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway.
|
| |
Proc Natl Acad Sci U S A,
100,
10653-10658.
|
|
|
|
|
|
|
T.A.Rouault
(2003).
How mammals acquire and distribute iron needed for oxygen-based metabolism.
|
| |
PLoS Biol,
1,
E79.
|
|
|
|
|
|
|
A.Bomford
(2002).
Genetics of haemochromatosis.
|
| |
Lancet,
360,
1673-1681.
|
|
|
|
|
|
|
A.Waheed,
J.H.Grubb,
X.Y.Zhou,
S.Tomatsu,
R.E.Fleming,
M.E.Costaldi,
R.S.Britton,
B.R.Bacon,
and
W.S.Sly
(2002).
Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.
|
| |
Proc Natl Acad Sci U S A,
99,
3117-3122.
|
|
|
|
|
|
|
C.N.Roy,
K.P.Blemings,
K.M.Deck,
P.S.Davies,
E.L.Anderson,
R.S.Eisenstein,
and
C.A.Enns
(2002).
Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.
|
| |
J Cell Physiol,
190,
218-226.
|
|
|
|
|
|
|
H.Drakesmith,
E.Sweetland,
L.Schimanski,
J.Edwards,
D.Cowley,
M.Ashraf,
J.Bastin,
and
A.R.Townsend
(2002).
The hemochromatosis protein HFE inhibits iron export from macrophages.
|
| |
Proc Natl Acad Sci U S A,
99,
15602-15607.
|
|
|
|
|
|
|
H.Li,
and
Z.M.Qian
(2002).
Transferrin/transferrin receptor-mediated drug delivery.
|
| |
Med Res Rev,
22,
225-250.
|
|
|
|
|
|
|
M.T.Dorak,
A.K.Burnett,
and
M.Worwood
(2002).
Hemochromatosis gene in leukemia and lymphoma.
|
| |
Leuk Lymphoma,
43,
467-477.
|
|
|
|
|
|
|
N.C.Andrews
(2002).
Metal transporters and disease.
|
| |
Curr Opin Chem Biol,
6,
181-186.
|
|
|
|
|
|
|
R.E.Fleming,
and
W.S.Sly
(2002).
Mechanisms of iron accumulation in hereditary hemochromatosis.
|
| |
Annu Rev Physiol,
64,
663-680.
|
|
|
|
|
|
|
Y.Kohgo,
Y.Torimoto,
and
J.Kato
(2002).
Transferrin receptor in tissue and serum: updated clinical significance of soluble receptor.
|
| |
Int J Hematol,
76,
213-218.
|
|
|
|
|
|
|
A.P.West,
L.L.Llamas,
P.M.Snow,
S.Benzer,
and
P.J.Bjorkman
(2001).
Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.
|
| |
Proc Natl Acad Sci U S A,
98,
3744-3749.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
C.A.Enns
(2001).
Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor.
|
| |
Traffic,
2,
167-174.
|
|
|
|
|
|
|
D.Barisani,
A.Parafioriti,
E.Armiraglio,
R.Meneveri,
and
D.Conte
(2001).
Duodenal expression of a putative stimulator of Fe transport and transferrin receptor in anemia and hemochromatosis.
|
| |
Gastroenterology,
120,
1404-1411.
|
|
|
|
|
|
|
P.T.Lieu,
M.Heiskala,
P.A.Peterson,
and
Y.Yang
(2001).
The roles of iron in health and disease.
|
| |
Mol Aspects Med,
22,
1.
|
|
|
|
|
|
|
S.Radaev,
B.Rostro,
A.G.Brooks,
M.Colonna,
and
P.D.Sun
(2001).
Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3.
|
| |
Immunity,
15,
1039-1049.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
W.J.Griffiths,
W.S.Sly,
and
T.M.Cox
(2001).
Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis.
|
| |
Gastroenterology,
120,
1420-1429.
|
|
|
|
|
|
|
W.L.Martin,
A.P.West,
L.Gan,
and
P.J.Bjorkman
(2001).
Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding.
|
| |
Mol Cell,
7,
867-877.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
W.Zhong,
W.P.Lafuse,
and
B.S.Zwilling
(2001).
Infection with Mycobacterium avium differentially regulates the expression of iron transport protein mRNA in murine peritoneal macrophages.
|
| |
Infect Immun,
69,
6618-6624.
|
|
|
|
|
|
|
B.D.Schneider,
and
E.A.Leibold
(2000).
Regulation of mammalian iron homeostasis.
|
| |
Curr Opin Clin Nutr Metab Care,
3,
267-273.
|
|
|
|
|
|
|
H.Drakesmith,
and
A.Townsend
(2000).
The structure and function of HFE.
|
| |
Bioessays,
22,
595-598.
|
|
|
|
|
|
|
J.E.Levy,
L.K.Montross,
and
N.C.Andrews
(2000).
Genes that modify the hemochromatosis phenotype in mice.
|
| |
J Clin Invest,
105,
1209-1216.
|
|
|
|
|
|
|
J.J.Pointon,
D.Wallace,
A.T.Merryweather-Clarke,
and
K.J.Robson
(2000).
Uncommon mutations and polymorphisms in the hemochromatosis gene.
|
| |
Genet Test,
4,
151-161.
|
|
|
|
|
|
|
M.C.Deller,
and
E.Yvonne Jones
(2000).
Cell surface receptors.
|
| |
Curr Opin Struct Biol,
10,
213-219.
|
|
|
|
|
|
|
M.Hirose
(2000).
The structural mechanism for iron uptake and release by transferrins.
|
| |
Biosci Biotechnol Biochem,
64,
1328-1336.
|
|
|
|
|
|
|
N.C.Andrews
(2000).
Inherited iron overload disorders.
|
| |
Curr Opin Pediatr,
12,
596-602.
|
|
|
|
|
|
|
R.Ehrlich,
and
F.A.Lemonnier
(2000).
HFE--a novel nonclassical class I molecule that is involved in iron metabolism.
|
| |
Immunity,
13,
585-588.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
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so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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