PDBsum entry 1cwc

Isomerase/immunosuppressant

PDB id

1cwc

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Contents

			Protein chains

					165 a.a. *


					11 a.a. *

			Waters ×169

* Residue conservation analysis

PDB id:

1cwc

Links
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Name:

Isomerase/immunosuppressant

Title:

Improved binding affinity for cyclophilin a by a cyclosporin derivative singly modified at its effector domain

Structure:

Peptidyl-prolyl cis-trans isomerase a. Chain: a. Synonym: ppiase, rotamase, cyclophilin a. Engineered: yes. Cyclosporin a. Chain: c. Synonym: cyclosporine, ciclosporin, ciclosporine. Engineered: yes. Mutation: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cyclophilin. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Tolypocladium inflatum. Organism_taxid: 29910

Resolution:

1.86Å

R-factor:

0.177

Authors:

V.Mikol

Key ref:

C.Papageorgiou et al. (1994). Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain. J Med Chem, 37, 3674-3676. PubMed id: 7966126 DOI: 10.1021/jm00048a002

Date:

06-Sep-95

Release date:

29-Jan-96

PROCHECK

	Headers

	References

Protein chain

P62937 (PPIA_HUMAN) - Peptidyl-prolyl cis-trans isomerase A from Homo sapiens

Seq: Struc:					165 a.a. 165 a.a.

Protein chain

No UniProt id for this chain

Struc:					11 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

Chain A: E.C.5.2.1.8 - peptidylprolyl isomerase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)

Peptidylproline (omega=180)	=	peptidylproline (omega=0)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1021/jm00048a002	J Med Chem 37:3674-3676 (1994)
PubMed id: 7966126

Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain.
C.Papageorgiou, A.Florineth, V.Mikol.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

17476570

K.Undheim (2008).
The Schöllkopf chiron and transition metal mediated reactions, a powerful combination for stereoselective construction of cyclic alpha-quaternary-alpha-amino acid derivatives.

Amino Acids, 34, 357-402.

12357034

L.Jin, and S.C.Harrison (2002).
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

Proc Natl Acad Sci U S A, 99, 13522-13526.

PDB code:

1mf8

11058892

M.T.Ivery (2000).
Immunophilins: switched on protein binding domains?

Med Res Rev, 20, 452-484.

7545076

S.Teague (1995).
Lessons from molecular matchmakers.

Nat Struct Biol, 2, 360-361.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.