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PDBsum entry 1cjh
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Unknown function PDB id
1cjh

 

 

 

 

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Contents
Protein chain
113 a.a.
Theoretical model
PDB id:
1cjh
Name: Unknown function
Title: Whey acidic protein (wap) from pig (sus scrofa)
Structure: Whey acidic protein. Chain: a. Fragment: two four-disulfide core domains. Synonym: pig wap, pwap
Source: Sus scrofa. Pig. Tissue: mammary gland. Secretion: milk
Authors: S.Ranganathan,K.J.Simpson,D.C.Shaw,K.R.Nicholas
Key ref: S.Ranganathan et al. (1999). The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling. J Mol Graph Model, 17, 106. PubMed id: 10680116 DOI: 10.1016/S1093-3263(99)00023-6
Date:
15-Apr-99     Release date:   19-Apr-99    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
O46655  (WAP_PIG) -  Whey acidic protein
Seq:
Struc: 		132 a.a.
113 a.a.
Key:    PfamA domain  Secondary structure

 

 
DOI no: 10.1016/S1093-3263(99)00023-6 J Mol Graph Model 17:106 (1999)
PubMed id: 10680116  
 
 
The whey acidic protein family: a new signature motif and three-dimensional structure by comparative modeling.
S.Ranganathan, K.J.Simpson, D.C.Shaw, K.R.Nicholas.
 
  ABSTRACT  
 
Whey acidic proteins (WAP) from the mouse, rat, rabbit, camel, and pig comprise two "four-disulfide core" domains. From a detailed analysis of all sequences containing this domain, we propose a new PROSITE motif ([KRHGVLN]-X-¿PF¿-X-[CF]-[PQSVLI]-X(9,19)-C-¿P¿-X-[DN]-X-¿N¿ -[CE]-X(5)-C-C) to accurately identify new four-disulfide core proteins. A consensus model for the WAP proteins is proposed, based on the human mucous proteinase inhibitor crystal structure. This article presents a detailed atomic model for the two-domain porcine WAP sequence by comparative modeling. Surface electrostatic potential calculations indicate that the second domain of the pig WAP model is similar to the functional human mucous proteinase inhibitor domains, whereas the first domain may be nonfunctional.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21118346 J.W.Van't Klooster, M.W.Van der Kamp, J.Vervoort, J.Beekwilder, S.Boeren, M.H.Joosten, B.P.Thomma, and P.J.De Wit (2011).
Affinity of Avr2 for tomato cysteine protease Rcr3 correlates with the Avr2-triggered Cf-2-mediated hypersensitive response.
  Mol Plant Pathol, 12, 21-30.  
21276224 N.Boumahrou, C.Bevilacqua, C.Beauvallet, G.Miranda, S.Andrei, E.Rebours, J.J.Panthier, S.Bellier, and P.Martin (2011).
Evolution of major milk proteins in Mus musculus and Mus spretus mouse species: a genoproteomic analysis.
  BMC Genomics, 12, 80.  
20379756 A.Tassanakajon, P.Amparyup, K.Somboonwiwat, and P.Supungul (2010).
Cationic antimicrobial peptides in penaeid shrimp.
  Mar Biotechnol (NY), 12, 487-505.  
18425600 C.Imjongjirak, P.Amparyup, A.Tassanakajon, and S.Sittipraneed (2009).
Molecular cloning and characterization of crustin from mud crab Scylla paramamosain.
  Mol Biol Rep, 36, 841-850.  
19732003 J.Li, S.Dowdy, T.Tipton, K.Podratz, W.G.Lu, X.Xie, and S.W.Jiang (2009).
HE4 as a biomarker for ovarian and endometrial cancer management.
  Expert Rev Mol Diagn, 9, 555-566.  
18676177 C.D.Bingle, and A.Vyakarnam (2008).
Novel innate immune functions of the whey acidic protein family.
  Trends Immunol, 29, 444-453.  
17942534 R.Alvarez, J.Reading, D.F.King, M.Hayes, P.Easterbrook, F.Farzaneh, S.Ressler, F.Yang, D.Rowley, and A.Vyakarnam (2008).
WFDC1/ps20 is a novel innate immunomodulatory signature protein of human immunodeficiency virus (HIV)-permissive CD4+ CD45RO+ memory T cells that promotes infection by upregulating CD54 integrin expression and is elevated in HIV type 1 infection.
  J Virol, 82, 471-486.  
17541952 N.Nukumi, T.Iwamori, K.Kano, K.Naito, and H.Tojo (2007).
Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin.
  J Cell Physiol, 213, 793-800.  
17697082 R.D.Rosa, P.T.Bandeira, and M.A.Barracco (2007).
Molecular cloning of crustins from the hemocytes of Brazilian penaeid shrimps.
  FEMS Microbiol Lett, 274, 287-290.  
16600032 L.Bingle, S.S.Cross, A.S.High, W.A.Wallace, D.Rassl, G.Yuan, I.Hellstrom, M.A.Campos, and C.D.Bingle (2006).
WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung.
  Respir Res, 7, 61.  
16022386 K.Lipnik, H.Petznek, I.Renner-Müller, M.Egerbacher, A.Url, B.Salmons, W.H.Günzburg, and C.Hohenadl (2005).
A 470 bp WAP-promoter fragment confers lactation independent, progesterone regulated mammary-specific gene expression in transgenic mice.
  Transgenic Res, 14, 145-158.  
16195641 T.Iwamori, M.Oosawa, N.Nukumi, K.Kano, K.Sudo, K.Naito, and H.Tojo (2005).
Aberrant development of mammary glands, but precocious expression of beta-casein in transgenic females ubiquitously expressing whey acidic protein transgene.
  J Reprod Dev, 51, 579-592.  
15007206 K.Ikeda, N.Nukumi, T.Iwamori, M.Osawa, K.Naito, and H.Tojo (2004).
Inhibitory function of whey acidic protein in the cell-cycle progression of mouse mammary epithelial cells (EpH4/K6 cells).
  J Reprod Dev, 50, 87-96.  
15056664 S.Carro, A.Bergo, M.Mengoni, A.Bachi, G.Badaracco, C.Kilstrup-Nielsen, and N.Landsberger (2004).
A novel protein, Xenopus p20, influences the stability of MeCP2 through direct interaction.
  J Biol Chem, 279, 25623-25631.  
14750148 T.D.Stoss, M.D.Nickell, D.Hardin, C.D.Derby, and T.S.McClintock (2004).
Inducible transcript expressed by reactive epithelial cells at sites of olfactory sensory neuron proliferation.
  J Neurobiol, 58, 355-368.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

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